Featured series 
Tag: Genetics
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Nation & World
Predicting risk of stroke from one’s genetic blueprint
A new statistical model could be used to predict an individual’s lifetime risk of stroke, according to the results of a study by Harvard researchers at the Children’s Hospital Boston Informatics Program.
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Nation & World
Common gene variants increase risk of hypertension
A new study has identified the first common gene variants associated with an increased incidence of hypertension — a significant risk factor for heart attack, stroke, and kidney failure. The…
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Nation & World
Neural wiring hints at nervous system gene limits
Genetics may play a surprisingly small role in determining the precise wiring of the mammalian nervous system, according to painstaking mapping of every neuron projecting to a small muscle mice use to move their ears. These first-ever mammalian “connectomes,” or complete neural circuit diagrams, reveal that neural wiring can vary widely even in paired tissues…
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Nation & World
International study identifies gene variants associated with early heart attack
The largest study ever completed of genetic factors associated with heart attacks has identified nine genetic regions — three not previously described — that appear to increase the risk for early-onset myocardial infarction. The report from the Myocardial Infarction Genetics Consortium, based on information from a total of 26,000 individuals in 10 countries, was given…
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Nation & World
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
Researchers have reported the first clinical evidence that gene therapy reduces symptoms in patients with rheumatoid arthritis (RA), an important milestone for this promising treatment . Described in the February issue of the journal Human Gene Therapy, the findings stem from a study of two patients with severe rheumatoid arthritis conducted in Germany and led…
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Nation & World
Scientists uncover new class of mammalian genes with key functions
A research team at the Broad Institute of Harvard and MIT and Beth Israel Deaconess Medical Center has uncovered a vast new class of previously unrecognized mammalian genes that do…
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Nation & World
New obesity-related genes identified
A large international consortium has made significant inroads into uncovering the genetic basis of obesity, adding six new genetic variants to the two already linked to higher body mass index (BMI) in previous studies. Most of the newly discovered genes had never before been suspected of having a role in body weight and, curiously, many…
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Nation & World
Research may lead to treatment for retinitis pigmentosa
Rods and cones coexist peacefully in healthy retinas. Both types of cells occupy the same layer of tissue and send signals when they detect light, which is the first step in vision.
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Nation & World
Of Neanderthals and dairy farmers
Harvard Archaeology Professor Noreen Tuross sought to rehabilitate the image of Neanderthals as meat-eating brutes last week, presenting evidence that, though they almost certainly ate red meat, Neanderthal diets also consisted of other foods — like escargot.
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Nation & World
Connie Cepko
In some ways, Connie Cepko’s job has gotten easier. The Harvard Medical School genetics professor is working to uncover the mysteries of the eye, to understand how it develops and…
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Nation & World
Genetic screening no better than traditional risk factors for predicting type 2 diabetes
Screening for a panel of gene variants associated with the risk for type 2 diabetes can identify adults at risk for the disorder but is not significantly better than assessment based on traditional risk factors such as weight, blood pressure, and blood sugar levels.
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Nation & World
For innovative undergrads, bacteria make some buzz
A team of undergraduates who engineered a bacterial biosensor with electrical output recently made some buzz at the 2008 international Genetically Engineered Machine (iGEM) competition held at the Massachusetts Institute of Technology (MIT).
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Nation & World
A single gene leads yeast cells to cooperate against threats
An ingenious social behavior that mobilizes yeast cells to cooperate in protecting each other from stress, antibiotics, and other dangers is driven by the activity of a single gene, scientists report this week in the journal Cell. The cooperating cells use the same gene, dubbed FLO1, as a marker for detecting “cheaters,” cells that try…
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Nation & World
Gary Ruvkun took a roundabout route to science
Gary Ruvkun has made a career out of imagining the unimaginable, and of surrounding himself with like-minded thinkers who let the wheels of thought spin until they catch on something hard, gain traction, and take off.
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Nation & World
Gene scan of Alzheimer’s families identifies four new suspect genes
The first family-based genome-wide association study in Alzheimer’s disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the…
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Nation & World
Gene therapy restores vision to mice with retinal degeneration
Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings of the National Academy of Sciences, describes the effects of broadly expressing a light-sensitive protein in other…
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Nation & World
Genome Project releases data on 10 genetic pioneers
The world moved a step deeper into the DNA age Monday (Oct. 20) as 10 volunteers released their genetic and medical information on the Internet as part of a multiyear effort to make genetic data an everyday part of medical care.
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Nation & World
Researchers identify promising gene target for neuroblastoma therapy
Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths.
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Nation & World
Volunteers unveil DNA, medical data in push for everyday gene sequencing
The world moved a step deeper into the DNA age yesterday as 10 volunteers released their genetic and medical information on the Internet as part of a multi-year effort to…
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Nation & World
Major step forward in cell reprogramming
Imagine, if you can, a day within the next decade when a physician-scientist could remove a skin cell from your arm and with a few chemicals turn that fully formed adult cell into a dish of stem cells genetically matched to you.
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Nation & World
Genetic ‘fingerprint’ shown to predict liver cancer’s return
Scientists have reached a critical milestone in the study of liver cancer that lays the groundwork for predicting the illness’s path, whether toward cure or recurrence. By analyzing the tissue in and around liver tumors, an international research team has identified a kind of genetic “fingerprint” that can help predict whether cancers will return.
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Nation & World
Harvard-affiliated gene study receives NIH funding
Two Harvard Medical School (HMS) professors of ophthalmology are co-principal investigators of a gene project that has received funding by the National Institutes of Health (NIH). Lou Pasquale and Janey Wiggs, both glaucoma researchers at the Massachusetts Eye and Ear Infirmary, are leading the grant-winning team of researchers that includes Vincent L. Gregory Professor in…
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Nation & World
New approach to gene therapy may shrink brain tumors, prevent their spread
Massachusetts General Hospital (MGH) researchers are investigating a new approach to gene therapy for brain tumors — delivering a cancer-fighting gene to normal brain tissue around the tumor to keep it from spreading. An animal study described in the journal Molecular Therapy, the first study to test the feasibility of such an approach, found that…
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Nation & World
Broad Institute gets major grant for epigenomics research
Researchers at the Broad Institute of Harvard and MIT announced Sept. 30 that they have received a grant from the National Institutes of Health (NIH) to map the epigenomes of a variety of medically important cell types, including human embryonic stem cells.
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Nation & World
NIH selects nine Pioneers, Innovators from Harvard
Nine Harvard faculty members are among 47 scientists nationally whose promising and innovative work was recognized Monday (Sept. 22) with the announcement of two grant programs through the National Institutes of Health (NIH).
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Nation & World
Stem cell summit hails bench progress, looks to bedside future
New discoveries concerning cell reprogramming over the past year have boosted stem cell researchers in the lab and encouraged efforts to transfer test tube and lab animal advances to humans suffering degenerative diseases such as diabetes, Parkinson’s disease, and Lou Gehrig’s disease.
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Nation & World
Harvard faculty members net MacArthur fellowships
Three biologists — one current and two future faculty members at Harvard — have won MacArthur Foundation “genius” grants, $500,000 no-strings-attached awards intended to encourage creativity, originality, and innovation in a broad array of fields.
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Nation & World
HPV, cervical cancer link earns scientists Alpert Prize
Two scientists who discovered that specific types of human papillomavirus, or HPV, cause cancer of the cervix received the 20th annual Warren Alpert Foundation Scientific Prize on Sept. 15. As part of the day’s celebration, the prize winners Harald zur Hausen and Lutz Gissmann — both professors at the German Cancer Research Center in Heidelberg…
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Nation & World
Ruvkun among Lasker Award winners
Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) investigator Gary Ruvkun is one of three co-recipients of the 2008 Lasker Award for Basic Medical Research.