Health
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Bile imbalance linked to liver cancer
Key molecular switch identified, sheds new light on treatment interventions
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FDA-approved smoking cessation pill helps break vaping habit
Clinical trial shows teens and young adults had three times more success quitting than their placebo counterparts
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U.S. pregnancy-related deaths continuing to rise
Study researcher says nation, which leads high-income peers in maternal mortality, needs better prenatal, extended postpartum care
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Rewriting genetic destiny
David Liu, Breakthrough Prize recipient, retraces path to an ‘incredibly exciting’ disease fighter: ‘This is the essence of basic science.’
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Why bother?
What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.
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Stopping the bleeding
Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’
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Texting their way to better health
A student project seeks to improve maternal and child care in India by using the proliferation of cellphones in rural areas to remind women to visit local clinics.
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Better blood
An innovative experimental treatment for boosting the effectiveness of blood stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, according to Harvard Stem Cell Institute scientists at Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Children’s Hospital Boston.
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One vaccine for two strains?
Harvard Medical School researchers believe that identifying the properties of the herpes viruses found in Africa could open the door to developing a more potent vaccine against an infection now rampant in sub-Saharan Africa.
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Speeding up biomolecular evolution
Scientists at Harvard University have harnessed the prowess of fast-replicating bacterial viruses, also known as phages, to accelerate the evolution of biomolecules in the laboratory.
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Helping the heart help itself
Stem cells being transfused into post-heart attack patients may not be developing into new heart muscle, but they still appear to be beneficial. Some stem cells in the bone marrow, called c-kit+ cells, appear capable of stimulating adult stem cells already present in the heart to repair damaged tissue.
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Debunking a myth
Studying dead women’s cut-up bodies was not what Katharine Park originally set out to do. But a trip to Florence opened a new chapter in the scholar’s life.
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The improbable appears promising
A section of the AIDS virus’ protein envelope once considered an improbable target for a vaccine now appears to be one of the most promising, new research by Harvard-affiliated Dana-Farber Cancer Institute scientists indicates.
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New hope for the cure
For the 20 percent of patients with so-called triple-negative breast cancer, the outcome is bleak. Now, however, researchers from Harvard Medical School (HMS) and Baylor College of Medicine have identified a critical molecular component to the disease, one that suggests potential therapies involving combinations of FDA-approved, readily available drugs.
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Brain changes found in normal elders
Harvard-affiliated researchers using two brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta — the primary constituent of the plaques found in the brains of Alzheimer’s disease patients — also had changes in brain structure similar to those seen in Alzheimer’s patients.
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Dose response
In a Harvard School of Public Health webcast, researchers used a recent federal report to start a conversation on vitamin D. How much is enough, and how much is too much?
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Kidney close-up
Scientists at Harvard have created breathtaking three-dimensional images of an entire organ, moving a step closer to understanding the complex development of the kidney.
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Progress against melanoma
Harvard stem cell researchers at Children’s Hospital Boston have taken two important steps toward development of a new way of treating melanoma, the most virulent form of skin cancer.
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Studying the roots of life
Key amino acids important for biological life are among the ones most easily formed in nature, according to Ralph Pudritz from McMaster University.
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Benefits of eating fish tip the scale
In a new, large-scale study from Harvard School of Public Health and Brigham and Women’s Hospital, researchers found no evidence that higher levels of mercury exposure were associated with higher risk of coronary heart disease, stroke, or total cardiovascular disease in two separate studies of U.S. adults.
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Multiple myeloma genome unveiled
Harvard scientists have unveiled the most comprehensive picture to date of the full genetic blueprint of multiple myeloma, a form of blood cancer.
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‘Circuits of sense and sensibility’
A Harvard biologist succeeds in mapping a neural network for learned olfactory behavior, using a roundworm model to trace the dislike of a particular smell to the reaction that avoids it.
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A fate in the stars
Astronomy Professor David Charbonneau is as enthusiastic about explaining his field to students as he is about researching faraway planets.
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Thinking ahead on diabetes
By measuring the levels of small molecules in the blood, doctors may be able to identify individuals at elevated risk of developing type 2 diabetes as much as a decade before symptoms of the disorder appear.
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Yes to testing children
According to a new study released online Monday (March 21), 60 percent of parents, whether they smoke or not, said they would like to have their children tested for tobacco smoke exposure during pediatric visits.
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Protein that helps battle HIV
Harvard researchers at Massachusetts General Hospital and the Ragon Institute of MGH, MIT and Harvard find that elevated levels of p21, a protein best known as a cancer fighter, may be involved in the immune system’s ability to control HIV infection.
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Deep thinker
Scientists are advancing in their understanding of the biology of the deep sea, which still remains largely unexplored and mysterious, according to Associate Professor Peter Girguis.
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The debate over mammograms
The debate over whether routine mammogram screenings are useful diagnostic tools or potentially ineffective and wasteful was the issue of a Harvard School of Public Health forum on March 8.
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Web-crawling the brain
Researchers in the Department of Neurobiology at Harvard Medical School have developed a technique for unraveling these masses. Through a combination of microscopy platforms, researchers can crawl through the individual connections composing a neural network, much as Google crawls web links.
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Child prodigies, maybe
Study suggests our assumptions about natural talent can influence our judgments, overlooking and undervaluing the impact of hard work.
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Harnessing your creative brain
Shelley Carson, a researcher in the Psychology Department and lecturer at the Extension School, has penned a how-to book on harnessing your untapped abilities.
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Study: Ibuprofen cuts Parkinson’s risk
A new study by Harvard School of Public Health researchers shows that adults who regularly take ibuprofen, a nonsteroidal anti-inflammatory drug, have about one-third less risk of developing Parkinson’s disease than nonusers.
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Dilemmas of destiny
As genetic testing and its offspring — personalized medicine — have matured, patients and doctors have become entangled in such issues as how to best share at-risk information, access treatment options, and weigh decisions about threats to the young and unborn. And sometimes these issues mushroom, becoming quandaries for society as a whole.
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Designing gene
Taking advantage of the simple color pattern of deer mice, Harvard researchers showed that small changes in the activity of a single pigmentation gene in embryos generate big differences in adult color pattern.
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Beyond DNA
On a day when Harvard celebrated the accomplishments of the Human Genome Project, the Radcliffe Institute hosted a scientist whose work focuses not just on DNA, but on the mechanisms that control its expression.
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Doing the neuron tango
A group of Harvard Stem Cell Institute researchers in the Department of Stem Cell and Regenerative Biology has discovered that excitatory neurons control the positioning of inhibitory neurons in the brain in a process critically important for generating balanced circuitry and proper cortical response.