Featured series 
Tag: David Scadden
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Health
Turns out lowly thymus may be saving your life
Study suggests organ plays vital role in immune health, particularly cancer prevention
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Science & Tech
A new way to target resistant cancer
Harvard University researchers have identified a unique characteristic of the resistant cancer cells, which could lead to an inhibitor can be repurposed and combined with chemotherapy to improve patient outcomes.
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Health
A solid vaccine for liquid tumors
A new study presents an alternative treatment for acute myeloid leukemia (AML) that has the potential to eliminate AML cells completely.
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Health
Toward safer bone-marrow transplants
The combination of the antibody CD117 and the drug saporin selectively targets blood stem cells, making transplantation safer by limiting collateral damage caused by the current standard of treatment, chemotherapy, and radiation.
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Arts & Culture
Stories that haunt them
In the days before Halloween, we asked Min Jin Lee, Maria Tatar, and other serious campus readers to share with us the stories that have scared them most — and why.
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Health
How old can we get? It might be written in stem cells
No clock, no crystal ball, but lots of excitement — and ambition — among Harvard scientists
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Health
Colorful clones track stem cells
Harvard Stem Cell Institute researchers have used a colorful cell-labeling technique to track the development of the blood system and trace the lineage of an adult blood cell traveling through the vast networks of veins, arteries, and capillaries back to its parent stem cell in the marrow.
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Health
Progress against acute myeloid leukemia
A new drug compound developed by researchers at Massachusetts General Hospital and the Harvard Stem Cell Institute to treat acute myeloid leukemia is gentle enough to use with patients too frail to endure chemotherapy.
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Health
Making bone marrow transplants safer
Harvard Stem Cell Institute scientists have taken the first steps toward developing a treatment that would make bone marrow-blood stem cell transplantation safer.
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Health
A promising strategy against HIV
Harvard Stem Cell Institute researchers at Massachusetts General and Boston Children’s hospitals for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
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Health
Undermining leukemia
A Harvard Stem Cell Institute study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant of shifts in their energy supply than their normal counterparts. The results suggest there could be ways to target and kill cancer cells without affecting healthy cells.
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Health
A decade of breakthroughs
The Harvard Stem Cell Institute is now 10 years old. What began as an idea embracing cross-disciplinary research quickly became a generator of scientific discoveries.
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Health
A cross-country collaboration
Amy Wagers and Emmanuelle Passegué have found that cancer stem cells actively remodel the environment of bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants.
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Campus & Community
Pausing to celebrate
More than 100 faculty, students, and staff from the Department of Stem Cell and Regenerative Biology turned out for a barbecue to celebrate the full-professor promotions of Kevin Eggan, Konrad Hochedlinger, and Amy Wagers.
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Campus & Community
Two named University Professors
Rebecca M. Henderson of the Harvard Business School and Douglas Melton of the Faculty of Arts and Sciences and the Harvard Medical School were named University Professors in recognition of their dedication to teaching and scholarship that crosses academic boundaries.
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Campus & Community
Zon, Scadden recognized by American Society of Hematology
Two Harvard faculty members and members of the Harvard Stem Cell Institute, David Scadden and Leonard Zon, have won awards from the American Society of Hematology for contributions to understanding and treating blood diseases.
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Health
Scadden, Zon win Hematology Society awards
Two Harvard professors will receive awards from the American Society of Hematology for their “significant contributions to the understanding and treatment of hematologic diseases.” David Scadden, who is co-director of the Harvard Stem Cell Institute, Jordan Professor of Medicine at Harvard Medical School, professor of stem cell and regenerative biology, and director of the Center for Regenerative Medicine at…
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Health
“Good” cells can go “bad” in a “bad neighborhood”
Normal.dotm 0 0 1 375 2142 Harvard University 17 4 2630 12.0 0 false 18 pt 18 pt 0 0 false false false The general theory of cancer development holds that malignancies occur because of the presence of certain genetic elements within the affected cells. But a new study by Harvard researchers at Massachusetts General…
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Health
Three Harvard teams to receive $9 million each in federal funding for stem cell research
Three teams of Harvard Stem Cell Institute (HSCI) researchers are slated to receive $27 million over seven years in National Heart Lung and Blood Institute (NHLBI) grants for the development of stem-cell based tools and treatments to understand and treat cardiovascular and blood disorders. The NHLBI Progenitor Cell Biology Consortium will consist of nine research…
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Health
Concentrating on stem cells
New concentration is the latest example of the University’s commitment to and pre-eminence in the promising field of stem cell research.
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Health
Mechanism directing stem cells to their destination identified;
Harvard Stem Cell Institute (HSCI) researchers have for the first time identified in mice a cellular mechanism that directs stem cells to their ultimate destination in the body. The finding in blood stem cells by HSCI co-director David Scadden and colleagues holds the promise of greatly increasing the efficiency of the bone marrow transplants used…
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Health
Faculty approves undergraduate concentration in human developmental, regenerative biology
Harvard’s Faculty of Arts and Sciences late today voted to approve a new undergraduate concentration, or major, in Human Development and Regenerative Biology. One of the first of its kind in the nation, the new program will be available this fall to students starting with current freshman, the Class of 2012. The concentration will focus…
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Science & Tech
Science, engineering programs advancing
Harvard President Drew Faust today renewed the University’s commitment to the vision of advancing interdisciplinary, collaborative science in general, and the Department of Stem Cell and Regenerative Biology (SCRB), the Harvard Stem Cell Institute (HSCI), and the Wyss Institute for Biologically Inspired Engineering (WIBIE) in particular. “These important, forward-looking programs are vital to the future…
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Health
Stem Cell Research: The Quest Resumes
“After eight years of political ostracism, stem-cell scientists like Harvard’s Douglas Melton are coming back into the light — and making discoveries that may soon bring lifesaving breakthroughs. Scientific inspiration can come from anywhere — a person, an event, even an experiment gone awry. But perhaps nothing can drive innovation more powerfully than the passion…
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Health
GlaxoSmithKline and Harvard Stem Cell Institute announce major collaboration agreement
GlaxoSmithKline (GSK) and the Harvard Stem Cell Institute (HSCI) today announced that they have entered into a five-year, $25 million-plus collaborative agreement to build a unique alliance in stem cell science to hasten the development of treatments and cures for a range of diseases. GSK’s investment, one of the largest by a pharmaceutical company in…
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Health
Cancer drug activates adult stem cells
The use of a drug used in cancer treatment activates stem cells that differentiate into bone appears to cause regeneration of bone tissue and be may be a potential treatment strategy for osteoporosis, according to a report in the February 2008 Journal of Clinical Investigation. The study – led by Harvard Stem Cell Institute (HSCI)…
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Health
Flier hails new, cooperative era in Harvard science
Harvard Medical School Dean Jeffrey Flier Friday evening issued a call for new approaches to advance the fight against disease, embracing cross-institutional collaborations at Harvard as a way to bring new thinking to old problems. Flier, the keynote speaker at the Fourth Annual Tony and Shelly Malkin Stem Cell Symposium at the Harvard Club of…
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Campus & Community
Advances in stem cell biology presented at symposium
Stem cell science is revolutionizing the field of cancer biology, changing the understanding of the structure of some tumors, and potentially shifting the treatment emphasis from eliminating all tumor cells to the destruction of specialized cancer stem cells believed responsible for tumor growth. These findings were among several presented Dec. 2 at the Harvard Club…
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Health
Stem cell science
“Stem-cell transplants are already performed every day in Harvard-affiliated hospitals — and around the world,” says Harvard Stem Cell Initiative codirector David Scadden, professor of medicine at Harvard Medical School and director of the Center for Regenerative Medicine at Massachusetts General Hospital. So-called bone-marrow transplants, which transfer tens of thousands of cells of many different…
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Health
Researchers boost blood cancer fight
Working with colleagues at the University of Rochester School of Medicine, Harvard researchers found that giving mice a hormone known for building bones increased their production of blood stem cells. If it works in humans as in mice, the advance could provide additional hope for patients suffering from leukemia, myeloma, or lymphoma who need bone…