A study led by Harvard-affiliated researchers is the first to demonstrate that BET bromodomain-containing proteins help execute inflammation in the endothelium while inhibition of BET bromodomain can significantly decrease atherosclerosis in vivo.
In an advance against cancer metastasis, scientists at the Harvard-affiliated Dana-Farber Cancer Institute have shown that a specially developed compound can impede multiple myeloma in mice from spreading to the bones.
New research raises the prospect of more effective treatments for cachexia, a profound wasting of fat and muscle that occurs in about half of all cancer patients, increasing their risk of death. Harvard Professor Bruce Spiegelman demonstrated that symptoms of cachexia in mice improved when given an antibody that blocked the effects of a protein secreted by the tumor cells.
A natural hormone that is increased by physical exercise and by exposure to cold improves blood sugar control, suppresses inflammation, and burns fat to mold leaner bodies in mice, report scientists at the Harvard-affiliated Dana-Farber Cancer Institute.
Scientists at the Wyss Institute for Biologically Inspired Engineering at Harvard University have discovered a way to build self-assembling cages made of DNA. The cages are the largest stand-alone DNA structures made to date, and one day may be able to deliver drugs or house tiny bioreactors or photonic devices inside the human body.
More than half of new cancer cases occur in low- and middle-income countries, as do nearly two-thirds of cancer deaths. Experts at a global oncology ...
“Beige fat” cells found in healthy subcutaneous fat in mice play a critical role in protecting the body against the disease risks of obesity, report Harvard researchers at the Dana-Farber Cancer Institute, who say their study findings may have implications for therapy of obesity-related illness in humans.
In the largest study of its kind, people who ate a daily handful of nuts were found to be 20 percent less likely to die from any cause over a 30-year period than those who didn’t consume nuts, say Harvard researchers.
They began with a discovery in zebrafish in 2007, and now researchers at the Harvard Stem Cell Institute (HSCI) have published initial results of a Phase Ib human clinical trial of a therapeutic that could improve the success of blood stem cell transplantation. This marks the first time that HSCI has carried a discovery from the lab bench to the clinic.
People who are married when diagnosed with cancer live longer than those who are not married. Married patients also tended to have cancers diagnosed at an earlier stage, according to Harvard researchers.
A cross-disciplinary team of Harvard scientists, engineers, and clinicians announced Sept. 6 that they have begun a Phase I clinical trial of an implantable vaccine to treat melanoma, the most lethal form of skin cancer.
An international scientific collaborative led by the Harvard Stem Cell Institute’s Kornelia Polyak has discovered why women who give birth in their early 20s are less likely to develop breast cancer than women who don’t, triggering a search for a way to confer this protective state on all women.
Scientists at Harvard-affiliated Dana-Farber Cancer Institute observed a strong and selective immune response in some patients who received several doses of a “personalized” tumor vaccine composed of their own inactivated leukemia cells combined with an immune stimulant.
Founding donor Hansjörg Wyss doubled his gift to Harvard’s Wyss Institute for Biologically Inspired Engineering from $125 million to $250 million to the University to further advance the institute’s pioneering work.
he National Football League Players Association (NFLPA) has awarded Harvard Medical School a $100 million grant to create a transformative 10-year initiative — Harvard Integrated Program to Protect and Improve the Health of NFLPA Members.
Two mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what Harvard scientists call the “dark matter” of the cancer genome, where cancer-related mutations haven’t been previously found.
Jane deLima Thomas, a palliative care physician and associate director of the Harvard Palliative Medicine Fellowship Program at Dana-Farber Cancer Institute, is one of five U.S. physicians to receive the 2013 Hastings Center Cunniff-Dixon Physician Award.
Some Harvard Medical School junior faculty members are receiving a bit of help at a difficult time in their lives, as they juggle the twin pressures of their demanding, developing careers and the consuming work of raising young families. These junior faculty have been awarded assistance through the Eleanor and Miles Shore 50th Anniversary Fellowship Program.
When Madeline Meehan makes her annual donation to Harvard Community Gifts, she won't just be providing handmade blankets to sick children, she’ll also be helping her mother’s labor of love. This is one of a series of Gazette articles highlighting some of the many initiatives and charities the can be supported through the Harvard Community Gifts campaign.
A Harvard panel examined the problem of clinics around the world that provide stem cell treatments for intractable conditions. Although there is no medical evidence of the treatments’ effectiveness, such clinics have drawn thousands of patients from many countries.
Researchers have found that colorectal cancer survivors whose diet and activity patterns lead to excess amounts of insulin in the blood have a higher risk of cancer recurrence and death from the disease.
Harvard researchers at Dana-Farber Cancer Institute find that aspirin therapy can extend the life of colorectal cancer patients whose tumors carry a mutation in a key gene, but it has no effect on patients who lack the mutation.
Flipping a newly discovered molecular switch in white fat cells enabled mice to eat a high-calorie diet without becoming obese or developing the inflammation that causes insulin resistance, report Harvard scientists from Dana-Farber Cancer Institute.
Researchers at Harvard-affiliated Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT used new technology to explore a 19-year-old theory, discovering what may be an Achilles’ heel for cancer cells: essential genes disrupted in the process of becoming cancerous that can be attacked further with drug therapy.
Adam J. Bass, assistant professor in the department of medicine at Harvard Medical School and assistant professor of medicine at the Dana-Farber Cancer Institute, has won a Doris Duke Charitable Foundation 2012 Clinical Scientist Development Award.
Scientists at Harvard-affiliated Dana-Farber Cancer Institute have isolated a new type of energy-burning fat cell in adult humans, which they say may have therapeutic potential for treating obesity.
Harvard researchers have found that although tailored drugs can eradicate melanoma cells in the lab, they often produce only partial, temporary responses in patients. Researchers have now learned that normal cells that reside within the tumor, part of the tumor microenvironment, may supply factors that help cancer cells grow and survive despite the presence of anti-cancer drugs.
HMS faculty Kenneth Anderson, Paul Richardson, and Alfred Goldberg are three of four researchers being honored for their research and development of a pioneering cancer drug.
Researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering have figured out how to use short lengths of DNA as physical, rather than genetic, building blocks, creating letters and other shapes from the molecules in a proof of design that could one day lead to the creation of structures that, among other things, deliver drugs to disease sites.
Researchers at Harvard Medical School and Harvard-affiliated Dana-Farber Cancer Institute have identified a protein that plays a key role in the long-mysterious effectiveness of an extremely low-calorie, high-fat, low-carbohydrate diet in suppressing epileptic seizures.
The American Association for Cancer Research (AACR) presented Alan D. D'Andrea with the 52nd Annual AACR G.H.A. Clowes Memorial Award for his work in understanding cancer survival and progression.
Scientists from Harvard-affiliated Brigham and Women's Hospital and Dana-Farber Cancer Institute and their colleagues have found a genetic marker that predicts which aggressive “triple-negative” breast cancers and certain ovarian cancers are likely to respond to platinum-based chemotherapies.
Two Harvard pediatric cancer researchers at Dana-Farber Cancer Institute (DFCI) and a scientist at Columbia University Medical Center have each received $100,000 Bridge Grants from a private foundation seeking to help make up for declining federal biomedical research funding.
Scientists at Dana-Farber Cancer Institute have identified a subtype of ovarian cancer able to build its own blood vessels, suggesting that such tumors might be especially susceptible to “anti-angiogenic” drugs that block blood vessel formation
A study by Harvard-affiliated Dana-Farber Cancer Institute finds that most terminally ill cancer patients discuss end-of-life care with physicians but that such discussions often occur late in their illness.
A team led by researchers at Harvard-affiliated Dana-Farber Cancer Institute has isolated a natural hormone from muscle cells that triggers some of the key health benefits of exercise.
Ninety instructors and junior faculty members at Harvard Medical School have received fellowships from the Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine. The program provides grants for recipients to hire lab help or to gain protected time by easing clinical duties.
David Rosenthal, who has been director of Harvard University Health Services for 23 years and oversaw both physical and electronic modernization, is stepping down at the end of the academic year.
Researchers at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute are collaborating on a massive, long-term effort to collect and analyze tumor tissue from 10,000 cancer patients annually. The researchers hope the data will enable them to understand better how tumors behave, while providing opportunities to test new therapies.
In a study that seems to pivot on a paradox, scientists at Harvard-affiliated Dana-Farber Cancer Institute have used an immune system stimulant as an immune system suppressor to treat a common, often debilitating side effect of donor stem cell transplantation in cancer patients. The effect, in some cases, was profound.
A combination of two drugs may alleviate radiation sickness in people who have been exposed to high levels of radiation, even when the therapy is given a day after the exposure occurred, according to a study led by scientists from Harvard-affiliated Dana-Farber Cancer Institute (DFCI) and Children’s Hospital Boston.
Report reveals that readily available and affordable cancer prevention, treatment, and pain relief interventions could decrease deaths and improve the lives of millions in developing countries.
Scientists at Harvard-afilliated Dana-Farber Cancer Institute and the Broad Institute have found strikingly high levels of a bacterium in colorectal cancers, a sign that it might contribute to the disease and potentially be a key to diagnosing, preventing, and treating it.
Flipping a single molecular switch can reverse illness in an animal model of sickle cell disease, according to a study by Harvard researchers at Children's Hospital Boston and Dana-Farber Cancer Institute.
Author and surgeon Atul Gawande says effective medicine requires high-quality care and solid research. But it also requires a willingness to adapt.
Scientists at Harvard-affiliated Dana-Farber Cancer Institute have successfully disrupted the function of a cancer gene involved in the formation of most human tumors by tampering with the gene’s “on” switch and growth signals, rather than targeting the gene itself.
Researchers from Harvard-affiliated Dana-Farber Cancer Institute and the Scripps Research Institute in Jupiter, Fla., report they have created prototype drugs having powerful anti-diabetic effects, yet apparently free — at least in mice — of dangerous side effects plaguing some current diabetes medications.
Baruj Benacerraf, who earned a 1980 Nobel Prize in physiology or medicine for his groundbreaking research in immunology and led Dana-Farber Cancer Institute through a period of tremendous growth beginning that year, died in Boston on Aug. 2 at the age of 90.
Harvard researchers at Dana-Farber Cancer Institute (DFCI) have identified a number of cancer genes that endow melanoma tumors with the ability to metastasize, making it possible to predict whether the tumors are likely to spread.
In their largest and most comprehensive effort to date, researchers from the Broad Institute of Harvard and MIT and Dana-Farber Cancer Institute, a Harvard affiliate, examined cells from more than 100 tumors, including 25 ovarian cancer tumors, to unearth the genes upon which cancers depend. They call it Project Achilles.