Drug resistance

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meats, fish, dairy, eggs, white meat on a wooden table as background

Dietary link found to drug-resistant breast cancer

Amino acid leucine, found in animal products and beans, blocks effectiveness of medications

Health|

DateMay 7, 2019January 30, 2020

Secondary tuberculosis in lungs and close-up view of Mycobacterium tuberculosis bacteria, 3D illustration

AI model predicts TB resistance

10 most common drugs targeted by undergrad’s neural network

Science|

DateMay 2, 2019July 9, 2019

Jim Collins opens “Data-Powered Strategies to Counteract Antibiotic Resistance,” a Medical School conference on how big data can be utilized to fight antibiotic resistance.

Big data targets drug resistance

Harvard symposium examines bioinformatics’ great potential in ensuring antibiotics’ effectiveness

Health|

DateJune 15, 2018June 18, 2018

The MEGA plate is a "powerful illustration of how easy it is for bacteria to become resistant to antibiotics,” said Roy Kishony holding a standard petri dish.

A cinematic approach to drug resistance

Scientists film bacteria’s maneuvers as they become impervious to drugs

Health|

DateSeptember 8, 2016September 8, 2016

“We’re not coming to the end of the antibiotic era, but we’re in danger of not being able to save lives we should save. We should be able to cure bacterial infections and viruses,” said Stuart Levy (right), a physician at Tufts University School of Medicine and president of the Alliance for the Prudent Use of Antibiotics. Levy was joined at the HSPH forum by Aaron Kesselheim (left), director of the Program on Regulation, Therapeutics, and Law at Brigham and Women’s Hospital, and HSPH epidemiology Professor Marc Lipsitch.

The threat from superbugs

Panel says dangers from increasingly ineffective antibiotics continue to rise

Health|

DateFebruary 9, 2014April 8, 2019

After the U.S. Centers for Disease Control and Prevention issued a report on the threat from drug-resistant bacteria, David Hooper, an authority on the subject, discussed the issues. "One of the organisms identified as urgent [by the CDC], carbapenem-resistant bacteria, are in many cases resistant to most of the antibiotics we have, and in some cases all of the antibiotics we have," he said.

When bacteria fight back

Q&A with David Hooper on the rising threat from drug-resistant microbes

Health|

DateSeptember 20, 2013

Harvard Professor Martin Nowak (left) and Ivana Bozic, a postdoctoral fellow in mathematics, are the co-authors of a recent paper that lays out a possible method for curing cancer. Their research shows that using two drugs, in certain circumstances, could eliminate the disease.

New plan of attack in cancer fight

Researchers demonstrate that a two-drug combination, under certain circumstances, can eliminate disease

Health|

DateJuly 18, 2013

Harvard's Alison Hill and Daniel Rosenbloom, along with Professor Martin Nowak (not pictured), have shown that the relationship between adherence to a drug regimen and resistance is different for each of the drugs that make up the “cocktail” used to control HIV. "What we demonstrate in this paper is a prototype for predicting, through modeling, whether a patient at a given adherence level is likely to develop resistance to treatment,” said Hill.

Forward thinking on HIV

Researchers develop model for designing more effective drug cocktails

Health|

DateSeptember 4, 2012March 18, 2019

“Many people are dying needlessly of cancer, and this research may offer a new strategy in that battle,” said Martin Nowak (left), director of the Program for Evolutionary Dynamics. Nowak and his team, including Benjamin Allen (right), a postdoctoral fellow in mathematical biology, focused on a multidrug approach to treatment that could make many cancers manageable, if not curable.

Transforming cancer treatment

Multidrug strategy emerges from new research

Health|

DateJuly 10, 2012March 6, 2019

The disease is mistakenly viewed as a problem of poverty. “TB doesn’t discriminate; anyone can get it,” said panelist Khisimuzi Mdluli (right). The symposium, moderated by Barry Bloom, focused on the reasons for the emergence of drug-resistant TB and what can be done to remedy this growing crisis. Among the panelists was Sarah Fortune (left), the Melvin J. and Geraldine L. Glimcher Assistant Professor of Immunology and Infectious Diseases at the Harvard School of Public Health.

Worry over drug-resistant TB

Panelists say money, mobilization needed to attack disease properly

Health|

DateJune 29, 2012June 13, 2019

Pleuni Pennings : “In order to prevent the evolution of resistance, we need to know where the resistance mutations are coming from. It was exciting to realize data from clinical trials could help us solve this puzzle."

The problem of pre-existing mutations

Researchers find that they can lead to drug resistance in HIV virus

Health|

DateJune 19, 2012