Tag: Molecular Genetics
-
Nation & World
Getting down to cases
Business neophytes at Harvard and MIT wrap up the annual case competition, stepping out of their everyday fields to learn about being business consultants.
-
Health
Two HSCI groups find residual genetic ‘memory’ in iPS cells;
Two groups of Harvard Stem Cell Institute researchers have independently made similar discoveries about the characteristics of induced pluripotent stem cells (iPSCs), but they have reached somewhat different conclusions about the implications…
-
Health
Mom’s influence comes first
Genome-wide analysis of mice brains has found that maternally inherited genes are expressed preferentially in the developing brain, while the pattern shifts decisively in favor of paternal influence by adulthood.…
-
Health
Tracking genetic traits over time
Fossils may provide tantalizing clues to human history, but they also lack some vital information, such as revealing which pieces of human DNA have been favored by evolution because they…
-
Health
Three-dimensional structure of human genome deciphered
Scientists have deciphered the three-dimensional structure of the human genome, paving the way for new insights into genomic function and expanding our understanding of how cellular DNA folds at scales…
-
Health
Jack Szostak 2009 Nobel Laureate in Physiology or Medicine
Jack Szostak, a genetics professor at Harvard Medical School and Harvard-affiliated Massachusetts General Hospital (MGH), has won the 2009 Nobel Prize in physiology or medicine for pioneering work in the…
-
Health
Genome of Irish potato famine pathogen decoded
A large international research team has decoded the genome of the notorious organism that triggered the Irish potato famine in the mid-19th century and now threatens this season’s tomato and…
-
Health
Maternal, paternal genes’ tug-of-war may last well into childhood
An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and…
-
Health
After a century, link between chromosomal instability and centrosome defects in cancer cells is unraveled
In a new study, Dana-Farber Cancer Institute scientists disprove a century-old theory about why cancer cells often have too many or too few chromosomes, and show that the actual reason…
-
Health
MicroRNA discovered to play role in DNA repair
Among their many roles as message couriers and gene regulators, microRNA molecules also help control the repair of damaged DNA within cells, Dana-Farber Cancer Institute and Harvard Medical School scientists…
-
Health
For cancer cells, genetics alone is poor indicator for drug response
In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups…
-
Health
Newly identified genetic variants found to increase breast cancer risk
A large-scale effort to identify genetic markers of breast cancer has uncovered two common genetic variants that increase risk of the disease in women of European ancestry. The paper, published…
-
Health
Scientists uncover new class of mammalian genes with key functions
A research team at the Broad Institute of Harvard and MIT and Beth Israel Deaconess Medical Center has uncovered a vast new class of previously unrecognized mammalian genes that do…
-
Health
Fresh insight into retinitis pigmentosa
Rods and cones coexist peacefully in healthy retinas. Both types of cells occupy the same layer of tissue and send signals when they detect light, which is the first step…
-
Health
Connie Cepko
In some ways, Connie Cepko’s job has gotten easier. The Harvard Medical School genetics professor is working to uncover the mysteries of the eye, to understand how it develops and…
-
Health
Eli and Edythe L. Broad endow the Broad Institute of Harvard and MIT with additional $400 million
Los Angeles-based philanthropists Eli and Edythe Broad today declared the Broad Institute of Harvard and MIT an unprecedented success as an experiment in science and philanthropy, and announced that they…
-
Health
A rare glimpse of schizophrenia’s genetic roots
The delusions and hallucinations of schizophrenia can be devastating for the 1% of the population struck by the disease. The condition clearly has a genetic component, evidenced by its tendency…
-
Health
Scientists use genomic tools to create maps of DNA methylation
Much of the field of stem cell biology and development remains uncharted territory. Just as famous explorers and astronomers mapped out landmasses and constellations, researchers are working fervently to chart…
-
Health
Gene variation may elevate risk of liver tumor in patients with cirrhosis
A genetic variation appears to significantly increase the risk that individuals with cirrhosis of the liver will develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause…
-
Health
Differences between malaria parasites in patients’ blood and in lab
In a groundbreaking study published today in the advance online edition of Nature, an international research team has for the first time measured which of the the malaria parasite’s genes are turned on or off during actual infection in humans, rather than in cell cultures, unearthing surprising behaviors and opening a window on the most…
-
Health
Scientists Decode Genomes of Diverse TB Isolates
An international collaboration led by researchers in the US and South Africa today announced the first genome sequence of an extensively drug resistant (XDR) strain of the bacterium Mycobacterium tuberculosis,…
-
Health
Study paints genetic portrait of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world’s leading cause of cancer deaths. Appearing in…
-
Health
First robust genetic link to height in humans identified
Over a century ago, scientists first proposed that height is a complex trait — one influenced by environmental factors and multiple genes. While subsequent studies revealed that most of the…
-
Campus & Community
Edmund Chi Chien Lin
Edmund Chi Chien Lin, Professor emeritus in Microbiology and Molecular Genetics, died peacefully in Boston on March 6, 2006.
-
Health
Harvard researchers map new form of genetic diversity
A new map of human genetic diversity provides a powerful tool for understanding how each person is unique. Created by researchers at Harvard Medical School, Brigham and Women’s Hospital, and…
-
Campus & Community
Sensitivity to pain explained
Stabbing back pain or the aches of arthritis send some people to bed in misery while the same distress seems easily tolerated by others.
-
Health
Study shows different insulin signaling components control glucose and lipid metabolism in the liver
Insulin uses two distinct mechanisms to control glucose and the metabolism of blood fats (lipids) in the liver, a new Joslin Diabetes Center-led study has discovered. Failures in each of…
-
Health
Proteasome recognized as nuclear player on gene-transcription team
One of the most common agents in the cytoplasm of the cell, the proteasome, also plays a widespread and critical role in transcription from inside the cell nucleus. Pam Silver,…