Schizophrenia

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Projection neurons of the cerebral cortex targeted for reprogramming are displayed in green.

Neurons reprogrammed in animals

Connections are properly ‘rewired,’ recognized, say researchers

Health|

DateNovember 4, 2015March 8, 2019

Researchers have identified a group of neurons in the basal forebrain that help synchronize activity in the cortex, triggering brain waves that are characteristic of consciousness, perception, and attention.

Tuning in on brain waves

Certain neurons act as conductors, suggesting possible therapies for disorders such as schizophrenia

Health|

DateMarch 2, 2015May 2, 2019

Philanthropist Ted Stanley announced plans to donate $650 million to the Broad Institute. The Stanley commitment — the largest ever in psychiatric research and among the largest for scientific research in general — will support research by a collaborative network of researchers within the Stanley Center for Psychiatric Research at the Broad Institute.

$650M gift to Broad seeks to propel psychiatric research

Broad Institute’s Stanley Center receives support in work on mental illness

Health|

DateJuly 22, 2014

“Because of the genetic complexity of schizophrenia and other psychiatric disorders, we need a large sample size to conduct this type of research," said Steve E. Hyman, director of the Broad’s Stanley Center for Psychiatric Research. Broad summer student Lydia Emerson prepares samples for sequencing in the Stanley Center lab in July. Research scientists Ellen Vieux and Tim Blosser collaborate in the background.

Researchers shed new light on schizophrenia

International team's work may lead to innovations in treatment that has seen little change in 60 years

Health|

DateJuly 21, 2014

Turning science on its head

Harvard researchers offer new views of body’s insulating material

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DateApril 18, 2014May 6, 2019

Researchers awarded NARSAD grants

Funds Harvard scientists to conduct innovative research on mental illness

News|

DateAugust 20, 2012

Assistant Professor Yun Zhang, shown in the Northwest Science Lab last year, is working with colleagues to illuminate "compartmentalized" neural activity in worms.

Following the worm

Harvard finding suggests path for study of neurological disorders

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DateMay 21, 2012April 23, 2019

Parvalbumin cells (blue) and one of the genes (red) that regulate their maturation in the cerebral cortex of a mouse. The connections made to and from these cells control critical periods of brain development and are vulnerable to mental illness. The Conte Center aims to map the wiring diagram, imprinted gene network, and functional maturation of these pivotal neurons using state-of-the-art microscopy and bioinformatics approaches.

Neurons in youth

Harvard study of brain development may shed light on disorders

Science|

DateNovember 17, 2011April 15, 2019

Norman Paul’s wide-ranging career focused on transgenerational family systems and the role of grief as a central influence in problems ranging from individual and marital problems to schizophrenia and epilepsy.

Norman Paul, family therapy pioneer, 85

News|

DateOctober 18, 2011

“There are hundreds of genes involved in susceptibility to schizophrenia and bipolar disorder. This study is able for the first time to articulate 10 conclusive genetic components to the disease, half of which are completely novel,” said Harvard Medical School Associate Professor of Medicine Mark J. Daly, a senior associate member of the Broad Institute and co-director of its Program in Medical and Population Genetics, and chief of the Analytic and Translational Genetics Unit at Massachusetts General Hospital.

Major study on schizophrenia, bipolar

International collaboration reveals 10 genetic risk factors

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DateSeptember 27, 2011June 6, 2019

NARSAD awards professors for breakthrough schizophrenia research

News|

DateSeptember 7, 2010

How brain cells make good connections

Understanding how synapses work may have profound implications

Health|

DateFebruary 14, 2008