Featured series 
Tag: Broad Institute of Harvard and MIT
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Health
A rare glimpse of schizophrenia’s genetic roots
The delusions and hallucinations of schizophrenia can be devastating for the 1% of the population struck by the disease. The condition clearly has a genetic component, evidenced by its tendency to run in families. However, the search for specific genes or chromosomal regions involved has led to few reproducible findings. Results published in Nature by…
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Health
Scientists use genomic tools to create maps of DNA methylation
Much of the field of stem cell biology and development remains uncharted territory. Just as famous explorers and astronomers mapped out landmasses and constellations, researchers are working fervently to chart the molecular landscapes within stem cells — especially embryonic stem cells. A clearer understanding of the cells’ unique properties, particularly their ability to give rise…
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Health
NIH awards Harvard Medical School $117.5 million, five-year grant for patient-centered research
The National Institutes of Health today announced that Harvard Medical School (HMS) will receive $117.5 million over the next five years for the establishment of a Clinical and Translational Science Center (CTSC) that will transform patient-oriented, laboratory-to-bedside research at HMS and its affiliated hospitals. Harvard University, HMS, and a number of the affiliated hospitals are…
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Health
Genomic analysis gives new insights into cellular reprogramming
A cross-disciplinary team of Harvard University, Whitehead Institute, and Broad Institute researchers has uncovered significant new information about the molecular changes that underlie the process by which adult cells can be reprogrammed to a stem cell-like state. Their findings are published online on May 28, 2008, in the journal Nature. “We used a genomic approach…
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Health
Chromosomal abnormality linked to autism disorders
Researchers have fitted another piece into the complex genetic puzzle that is autism, finding DNA deletions and duplications on a specific chromosome that they say explains one to two percent of the 1.5 million cases of autism and related disorders in the United States today. The genetic changes were discovered in DNA scans of more…
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Health
Differences between malaria parasites in patients’ blood and in lab
In a groundbreaking study published today in the advance online edition of Nature, an international research team has for the first time measured which of the the malaria parasite’s genes are turned on or off during actual infection in humans, rather than in cell cultures, unearthing surprising behaviors and opening a window on the most…
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Health
Scientists Decode Genomes of Diverse TB Isolates
An international collaboration led by researchers in the US and South Africa today announced the first genome sequence of an extensively drug resistant (XDR) strain of the bacterium Mycobacterium tuberculosis, one linked to more than 50 deaths in a recent tuberculosis (TB) outbreak in KwaZulu-Natal, South Africa. As part of this work, genomes of multi-drug…
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Health
Study paints genetic portrait of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world’s leading cause of cancer deaths. Appearing in the November 4 advance online issue of the journal Nature, the research provides a comprehensive view of the abnormal genetic landscape in lung cancer cells,…
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Health
Researchers track down rheumatoid arthritis gene
Researchers at Brigham and Women’s Hospital (BWH) and the Broad Institute of MIT and Harvard have discovered a gene involved in rheumatoid arthritis, a painful autoimmune disease that affects 2.1 million Americans and can destroy cartilage and bone within the afflicted joint. In a study led by Robert Plenge, an instructor in medicine at Harvard…
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Health
Database of human genetic diversity allows identification of disease-associated genes
Investigators from six countries have completed the second phase of the International HapMap Project, an effort to identify and catalog genetic similarities and differences among populations around the world. Information provided in the first phase of the HapMap, completed in 2005, has led to the development of techniques facilitating the search for genes associated with…
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Health
First robust genetic link to height in humans identified
Over a century ago, scientists first proposed that height is a complex trait — one influenced by environmental factors and multiple genes. While subsequent studies revealed that most of the variation in adult height is genetically determined, there has been little success in pinpointing the responsible genes. Some clues have come from rare syndromes of…
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Health
Opossum genome shows ‘junk’ DNA source of genetic innovation
A tiny opossum’s genome has shed light on how evolution creates new creatures from old, showing that change primarily comes by finding new ways of turning existing genes on and off. The research, by an international consortium led by the Broad Institute of MIT and Harvard, revises our understanding of genetic evolution. Scientists previously thought…
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Campus & Community
HSPH, Broad map malaria genetic diversity
Researchers have created the first map of genetic diversity of the malaria parasite, providing new insights in the fight against a public health scourge that kills one person every 30 seconds.
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Campus & Community
Genetic ‘road map’ leads to discoveries
A research team led by scientists at the Broad Institute of MIT and Harvard announced Sept. 28 the development of a new kind of genetic “road map” that can connect human diseases with potential drugs to treat them, as well as predict how new drugs work in human cells. Called the “connectivity map,” the new…
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Campus & Community
Did ancestral humans, chimps interbreed?
New scientific findings indicate that ancestral humans split from chimpanzee forebears more recently than previously thought and raise the possibility that the two nascent species hybridized before making their final separation.
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Health
Dog genome unleashed
An international research team led by scientists at the Broad Institute of MIT and Harvard has decoded the DNA of the domestic dog and pinpointed millions of genetic differences that distinguish dog breeds. The study also includes the first comparative analysis to encompass three distinct mammalian genomes, revealing important DNA elements common among them. Such…
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Campus & Community
HapMap reveals roots of common diseases
The genes that everyone inherits contain coded information that influences which diseases any individual is most at risk of getting. Countless studies show that small variations in genes play a major role in a host of common maladies that produce untold suffering and premature death. However, progress in tying these variations to specific maladies has…
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Campus & Community
HapMap: First look at ‘order in variety’ of human genome
The completion of the human genome sequence in 2003, though momentous, was only the first step toward grasping the core mechanisms of human biology and disease. This ultimate biomedical goal also requires a comprehensive catalog of the genetic diversity in the human genome sequence across human populations. A flurry of high-profile scientific papers published this…
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Science & Tech
First edition of HapMap released
A flurry of high-profile scientific manuscripts published in October 2005 describe both the content and uses of HapMap, a catalog that maps human genetic variation and relates it both to disease and to human evolutionary history. HapMap gives scientists worldwide a first good look at the “order in variety” that is the human genome. All…
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Campus & Community
Chimp genome effort shines light on human evolution
A research effort, led by scientists at the Broad Institute of MIT and Harvard, the Washington University School of Medicine in St. Louis, and the University of Washington, Seattle, focused on the chimpanzee in hopes that genetic comparisons with humanity’s closest relative will lead to answers to both practical questions – such as the causes…
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Campus & Community
A new way to identify cancers is found
Scientists are surprised and delighted that a recently discovered group of small molecules show an unexpected potential for easily distinguishing healthy cells from tumors and one type of cancer from others. These molecules, known as microRNAs (miRNAs), provide fingerprints that may enable doctors to quickly and inexpensively diagnose any type of cancer. When miRNAs are…
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Health
Novel combination overcomes drug-resistant multiple myeloma cells
The researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Velcade and an experimental compound that was designed by researchers at the Broad Institute of the Massachusetts Institute of Technology and Harvard University. The report demonstrates that the combination was more than twice as effective as either drug…
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Health
Protein packages activate genes
It’s all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and M.I.T. They did the largest, most detailed study to date of the protein structure that surrounds the human genome. Their findings reveal surprising and previously unknown specifics of how genes get…