Tag: Broad Institute of Harvard and MIT
-
Nation & World
A rare glimpse of schizophrenia’s genetic roots
The delusions and hallucinations of schizophrenia can be devastating for the 1% of the population struck by the disease. The condition clearly has a genetic component, evidenced by its tendency…
-
Nation & World
Scientists use genomic tools to create maps of DNA methylation
Much of the field of stem cell biology and development remains uncharted territory. Just as famous explorers and astronomers mapped out landmasses and constellations, researchers are working fervently to chart…
-
Nation & World
NIH awards Harvard Medical School $117.5 million, five-year grant for patient-centered research
The National Institutes of Health today announced that Harvard Medical School (HMS) will receive $117.5 million over the next five years for the establishment of a Clinical and Translational Science…
-
Nation & World
Genomic analysis gives new insights into cellular reprogramming
A cross-disciplinary team of Harvard University, Whitehead Institute, and Broad Institute researchers has uncovered significant new information about the molecular changes that underlie the process by which adult cells can…
-
Nation & World
Chromosomal abnormality linked to autism disorders
Researchers have fitted another piece into the complex genetic puzzle that is autism, finding DNA deletions and duplications on a specific chromosome that they say explains one to two percent…
-
Nation & World
Differences between malaria parasites in patients’ blood and in lab
In a groundbreaking study published today in the advance online edition of Nature, an international research team has for the first time measured which of the the malaria parasite’s genes are turned on or off during actual infection in humans, rather than in cell cultures, unearthing surprising behaviors and opening a window on the most…
-
Nation & World
Scientists Decode Genomes of Diverse TB Isolates
An international collaboration led by researchers in the US and South Africa today announced the first genome sequence of an extensively drug resistant (XDR) strain of the bacterium Mycobacterium tuberculosis,…
-
Nation & World
Researchers track down rheumatoid arthritis gene
Researchers at Brigham and Women’s Hospital (BWH) and the Broad Institute of MIT and Harvard have discovered a gene involved in rheumatoid arthritis, a painful autoimmune disease that affects 2.1…
-
Nation & World
Study paints genetic portrait of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world’s leading cause of cancer deaths. Appearing in…
-
Nation & World
Database of human genetic diversity allows identification of disease-associated genes
Investigators from six countries have completed the second phase of the International HapMap Project, an effort to identify and catalog genetic similarities and differences among populations around the world. Information…
-
Nation & World
First robust genetic link to height in humans identified
Over a century ago, scientists first proposed that height is a complex trait — one influenced by environmental factors and multiple genes. While subsequent studies revealed that most of the…
-
Nation & World
Opossum genome shows ‘junk’ DNA source of genetic innovation
A tiny opossum’s genome has shed light on how evolution creates new creatures from old, showing that change primarily comes by finding new ways of turning existing genes on and…
-
Nation & World
HSPH, Broad map malaria genetic diversity
Researchers have created the first map of genetic diversity of the malaria parasite, providing new insights in the fight against a public health scourge that kills one person every 30 seconds.
-
Nation & World
Genetic ‘road map’ leads to discoveries
A research team led by scientists at the Broad Institute of MIT and Harvard announced Sept. 28 the development of a new kind of genetic “road map” that can connect…
-
Nation & World
Did ancestral humans, chimps interbreed?
New scientific findings indicate that ancestral humans split from chimpanzee forebears more recently than previously thought and raise the possibility that the two nascent species hybridized before making their final separation.
-
Nation & World
Dog genome unleashed
An international research team led by scientists at the Broad Institute of MIT and Harvard has decoded the DNA of the domestic dog and pinpointed millions of genetic differences that…
-
Nation & World
HapMap reveals roots of common diseases
The genes that everyone inherits contain coded information that influences which diseases any individual is most at risk of getting. Countless studies show that small variations in genes play a…
-
Nation & World
HapMap: First look at ‘order in variety’ of human genome
The completion of the human genome sequence in 2003, though momentous, was only the first step toward grasping the core mechanisms of human biology and disease. This ultimate biomedical goal…
-
Nation & World
First edition of HapMap released
A flurry of high-profile scientific manuscripts published in October 2005 describe both the content and uses of HapMap, a catalog that maps human genetic variation and relates it both to…
-
Nation & World
Chimp genome effort shines light on human evolution
A research effort, led by scientists at the Broad Institute of MIT and Harvard, the Washington University School of Medicine in St. Louis, and the University of Washington, Seattle, focused…
-
Nation & World
A new way to identify cancers is found
Scientists are surprised and delighted that a recently discovered group of small molecules show an unexpected potential for easily distinguishing healthy cells from tumors and one type of cancer from…
-
Nation & World
Novel combination overcomes drug-resistant multiple myeloma cells
The researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Velcade and an experimental compound that was designed by researchers at the Broad…
-
Nation & World
Protein packages activate genes
It’s all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and M.I.T. They did the largest, most…