Health
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A promising first for researchers probing mental illness
Anxiety finding a highlight as brain stimulation trial raises new hopes for precision care
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Read before running
New to the sport or just rusty? A rehab doc offers tips on avoiding all-too-common injuries.
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How loneliness became major public health issue
U.K., U.S. experts trace rise in awareness through research, political involvement, pandemic
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Predicting cancer outcomes with a selfie
Slower ‘face aging’ linked to better survival odds, according to second study of AI tool designed to aid precision care
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When stress is a punch to the gut
New study traces network of nerves that disrupt digestion, pointing to potential IBS treatment
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Food as medicine? How nutrition can improve cancer outcomes.
Tufts professor shares early research regarding programs as part of oncology care
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Study suggests obesity has lesser financial impact on African-Americans
The study published in the January 2005 issue of the American Journal of Public Health is among the first to examine how patient demographic factors affect the relationship between body…
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Faulty gene signaling could lead to development of Crohn’s disease
According to the study’s lead author, Brigham Women’s Hospital’s Derek W. Abbott, “The discovery of this faulty signaling process is a first step in helping us understand and ultimately address the underlying mechanism that causes Crohn’s disease to develop.
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Study finds that both weight and exercise are key to longevity
Over 115,000 participants who were free of cardiovascular disease or cancer, who were between the ages of 30 and 55 and had filled out biennial health and lifestyle questionnaires between…
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Molecule implicated in transcription termination
When a protein is made its DNA code must first be rewritten as messenger RNA (mRNA). This process of transcription requires a large enzyme complex, RNA polymerase, to begin at…
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DNA splicing enzyme observed in action
Researchers in the lab of Tom Ellenberger, the Hsien Wu and Daisy Yen Wu professor of biological chemistry and molecular pharmacology at Harvard Medical School, reported the doughnut shape of…
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Protein reverses engineering of chromosome structure
An enzyme, a histone demethylase, removes methyl groups appended to histones, nuclear proteins that organize DNA and regulate gene activity. Methyl groups and other chemical tags on histones regulate how…
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Researchers find high levels of potentially toxic heavy metals in herbal medicine products
“This study, yet again, highlights the need for Congress to revisit the way dietary supplements are regulated in the U.S.,” said co- author David Eisenberg, MD, the Bernard Osher Associate…
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Study finds women hesitant to take tamoxifen as preventive measure
“Our study underscores the need [for medical professionals] to address psychological factors that may influence decision- making, in order to help women feel confident and satisfied with their treatment choice,”…
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Accumulated low-level lead exposure can lead to cataract development in men
According to lead author Debra A. Schaumberg, Sc.D., O.D., M.P.H. of BWH, “This research suggests that reduction of lead exposure throughout a man’s lifetime should help reduce his chances of…
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Sudden death among military personnel often caused by exercise and an identifiable cardiac abnormality
According to the study’s lead author BWH’s Robert E. Eckart, D.O., they had expected that most of the sudden deaths would stem from structural heart abnormalities, but that in actuality,…
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Grandkids can make you sick
A study by researchers from the Harvard School of Public Health and Harvard Medical School shows that women who care for grandchildren more than nine hours a week have a…
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Elevated BMI may not increase risk of death among men with heart attack or stroke
“This study does not eliminate a small amount of risk for being overweight or obese,” said author Howard D. Sesso, Sc.D., M.P.H., of BWH. “However, it does tell physicians that…
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Drugs are effective against eye disease
Results of two large international clinical trials have shown positive results using Macugen, an experimental treatment that targets the abnormal blood vessels found in the “wet” form of macular degeneration.…
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Gene expression profiling helps in ovarian cancer prognosis
Steven A. Cannistra, M.D., director of Gynecologic Medical Oncology at BIDMC and associate professor of medicine at Harvard Medical School, says ovarian cancer is often not detectable until its later…
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Studies demonstrate positive data in treatment of hepatitis C
Presented by Nezam Afdhal, M.D., chief of Hepatology at Beth Israel Deaconess Medical Center (BIDMC) and associate professor of medicine at Harvard Medical School, the new findings demonstrate promising results…
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Risk of becoming resistant to antibiotics may be lower than expected for chronic sinus infection sufferers
“This study was designed to help determine how great a risk antibiotic resistance was among chronic sinus patients to determine if there is a need to re-evaluate how we diagnose…
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Study finds that blacks are significantly less likely to undergo prostate cancer screening
In a study involving more than 67,000 men age 65 years and older, the researchers found that blacks were 35 percent less likely than whites to undergo prostate-specific antigen (PSA)…
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Study says therapy better than pills in treating sleep-onset insomnia
The findings show non-drug techniques yield better short- and long-term results than the most widely prescribed sleeping pill, zolpidem, commonly known as Ambien. “Sleeping pills are the most frequent treatment…
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Walking improves cognitive functions in older women
In a study, elderly women who engaged in the most activity — for example, walking at least 6 hours per week — had a 20 percent decrease in risk of…
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Mechanism helps describe how airways respond to constriction
In asthma, substances such as allergens irritate the airways and cause the smooth muscle cells around them to contract. With repeated attacks, lung tissues become damaged from cycles of inflammation…
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The tale of the tail
Sharks’ tails have always mystified biologists. Their relatives, hundreds of different species of fish, happily push themselves through the water with symmetrical tails that move from side to side. But…
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Study finds leptin plays a key role in women’s health
Senior author Christos Mantzoros, M.D., director of the Human Nutrition Research Unit and clinical research overseer of the Department of Endocrinology at BIDMC and associate professor of medicine at Harvard…
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Surprising variations discovered in human genomes
Researchers from Harvard Medical School and the University of Toronto in Canada looked at 55 healthy, unrelated men and women, and they discovered 255 regions with relatively large gains or…
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Images reveal how leading cause of severe childhood diarrhea enters cells
The work illustrates how vaccine development can advance by probing the physical architecture of viruses and finding the parts needed to prime the immune system. Rotavirus, which causes severe diarrhea…
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Drug-coated stents don’t save money but are reasonably cost-effective, study shows
Treatment with the Cypher sirolimus-coated stent, developed by Johnson & Johnson’s Cordis division, cost approximately $2,900 more per patient compared to the use of bare metal stents. The drug is…
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Which comes first, language or thought?
“Infants are born with a language-independent system for thinking about objects,” says Elizabeth Spelke, a professor of psychology at Harvard. “These concepts give meaning to the words they learn later.”…
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Study yields insights into precancerous condition
Caused by a mutation that inactivates the tumor suppressor gene LKB1, PJS causes gastrointestinal polyps that have a 30 to 50 percent chance of becoming cancerous, says senior author Lewis…
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Stem cell science
“Stem-cell transplants are already performed every day in Harvard-affiliated hospitals — and around the world,” says Harvard Stem Cell Initiative codirector David Scadden, professor of medicine at Harvard Medical School…
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Quality of life continues to change long-term after treatment for prostate cancer
Researchers compared outcomes for men who had undergone surgery or radiation in the first study to look at the effects of prostate cancer treatment on quality of life beyond five…
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Newly identified gene linked to brain development
Bilateral frontoparietal polymicrogyria (BFPP) is a recessive genetic disorder resulting in severely abnormal architecture of the brain’s frontal lobes, as well as milder involvement of parietal and posterior parts of…