Tag: Stuart Orkin

  • Nation & World

    Prospect of shorter treatment and cure for chronic myelogenous leukemia

    Chronic myelogenous leukemia (CML) is a slowly progressing type of blood cancer that develops in the bone marrow. Researchers discovered that CML stem cells die in response to inhibition of a protein called Ezh2. Drugs that target the protein are currently being tested in clinical trials for other cancers.

    4 minutes
  • Nation & World

    Finally, hope for a young patient

    A gene therapy trial points to a healthier future for a young patient suffering from a rare immune disease.

    16 minutes
  • Nation & World

    New hope in regenerative medicine

    Harvard Stem Cell Institute researchers at Boston Children’s Hospital have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells have the functional hallmarks of HSCs and are able to self-renew like those cells.

    4 minutes
  • Nation & World

    Dialing down sickle cell disease

    Flipping a single molecular switch can reverse illness in an animal model of sickle cell disease, according to a study by Harvard researchers at Children’s Hospital Boston and Dana-Farber Cancer Institute.

    5 minutes