The Harvard Gazette

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Barack Obama.

Feel like kids, spouse, work giving you gray hair? They may be

New findings involving nervous system and stem cells suggest just how stress may trigger the change

Science|

DateJanuary 22, 2020February 18, 2020

Using a new, stem cell-based, drug-screening technology developed by Professor Lee Rubin at the Harvard Stem Cell Institute, researchers have found a compound that is more effective in protecting the neurons killed in ALS than the two drugs that failed in human clinical trials.

Big boost in drug discovery

New use for stem cells identifies a promising way to target ALS

Health|

DateApril 18, 2013September 12, 2019

Using skin cells of patients with cystic fibrosis, Jayaraj Rajagopal (right) and colleagues have created induced pluripotent stem (iPS) cells. “We’re not talking about a cure for CF; we’re talking about a drug that hits the major problem in the disease. This is the enabling technology that will allow that to happen in a matter of years,” said Rajagopal, the senior author on the paper. Postdoctoral fellow Hongmei Mou (left) is first author on the paper. The work is featured on the cover of this week’s journal Cell Stem Cell.

Big advance against cystic fibrosis

Stem cell researchers create lung surface tissue in a dish

Health|

DateApril 5, 2012April 8, 2019

FAS Dean Michael D. Smith (from left), congratulates Alice Belser from the Department of the History of Science. Belser's brother, Jeff, joined her at the ceremony, which recognized 44 FAS employees with the Dean’s Distinction award.

FAS recognizes outstanding staff members

Forty-four are honored with Dean’s Distinction awards

News|

DateMarch 6, 2012March 6, 2019

Steven Hyman, neuroscientist, former Harvard University provost, and former head of NIMH, has been named the new director of the Broad Institute’s Stanley Center for Psychiatric Research.

Hyman to lead Broad research center

Former provost named director of Stanley Center for Psychiatric Research

News|

DateFebruary 15, 2012April 22, 2019

In a study, researchers report that defects in the regeneration of the myelin sheaths surrounding nerves, which are lost in diseases such as MS, may be at least partially corrected after exposing an old animal to the circulatory system of a young animal. The research was led by Associate Professor Amy Wagers (above) of Harvard’s Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute.

Age-related effects of MS may prove reversible

Study provides hope of stimulating myelin sheaths around nerves

Health|

DateJanuary 6, 2012March 20, 2019

Harvard researchers report the first creation of a stem cell line containing a patient’s genome using SCNT — somatic cell nuclear transfer. The papers also include an experiment explaining why other attempts at SCNT have been unsuccessful; and a commentary reporting that it is impractical if not impossible to recruit ova donors without paying them.

Stem cell lessons

Insights on somatic cell nuclear transfer in studies, commentary

Health|

DateOctober 5, 2011May 22, 2019

“One of the utilities [of this new method for producing motor neurons] is it makes a much more rapid way to grow motor neurons. This could allow us to test very rapidly whether a new therapeutic is likely to be effective,” said Kevin Eggan, leader of the Harvard team of stem cell researchers that has succeeded in reprogramming adult mouse skin cells directly into the type of motor neurons damaged in Lou Gehrig's disease and spinal muscular atrophy.

From skin cells to motor neurons

Researchers find success with direct cellular reprogramming

Health|

DateAugust 26, 2011March 13, 2019

A team of Harvard Stem Cell Institute (HSCI) researchers, in collaboration with scientists at Columbia University Medical Center, have demonstrated that many iPS cells are the equal of hESCs in creating human motor neurons, the cells destroyed in a number of neurological diseases, including Parkinson’s.

Two studies prove value of iPS cells

New method effective in testing against embryonic stem cells

Health|

DateFebruary 8, 2011April 23, 2019