Featured series 
Tag: Harvard Medical School
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Science & Tech
The genes in your congeniality:
Can’t help being the life of the party? Maybe you were just born that way. Researchers at Harvard and the University of California, San Diego, have found that our place in a social network is influenced in part by our genes, according to new findings published in the Proceedings of the National Academy of Sciences.…
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Science & Tech
Implants mimic infection to rally immune system against tumors
Harvard bioengineers have shown that small plastic disks impregnated with tumor-specific antigens and implanted under the skin can reprogram the mammalian immune system to attack tumors. The research — which rid 90 percent of mice of an aggressive form of melanoma that would usually kill the rodents within 25 days — represents the most effective…
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Health
Topical treatment wipes out herpes with RNAi
Harvard Medical School researchers have succeeded in developing a topical treatment that, in mice, wipes out herpes virus, one of the most intractable sexually transmitted human diseases. Judy Lieberman, professor of pediatrics and a senior investigator at the Immune Disease Institute, has overseen the development of the treatment that uses RNA interference, or RNAi, to…
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Science & Tech
Inmates suffer from chronic illness, poor access to health care
The nation’s prison and jail inmate population struggles with high rates of serious illness and poor access to care, according to the first nationwide study of inmate health and health care. The research, conducted by Harvard physicians at the Cambridge Health Alliance and Harvard Medical School (HMS) and published today by the American Journal of…
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Health
Surgical safety checklist drops deaths and complications by more than one-third
A group of hospitals in eight cities around the globe has successfully demonstrated that the use of a simple surgical checklist during major operations can lower the incidence of deaths and complications by more than one-third. The rate of major complications in the study operating rooms fell from 11 percent in the baseline period to…
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Health
Spinal tap unnecessary for most babies with uncomplicated febrile seizures
When babies develop a fever high or abrupt enough to cause a seizure, frightened parents often rush them to the emergency room, where their workup frequently includes a lumbar puncture (spinal tap) to rule out bacterial meningitis. Now, in the largest study to date, Harvard researchers at Children’s Hospital Boston find that this uncomfortable procedure…
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Health
Obesity: Reviving the promise of leptin
The discovery more than a decade ago of leptin, an appetite-suppressing hormone secreted by fat tissue, generated headlines and great hopes for an effective treatment for obesity. But hopes dimmed when it was found that obese people are unresponsive to leptin due to development of leptin resistance in the brain. Now, Harvard researchers at Children’s…
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Health
Antacid medication in pregnancy may increase childhood asthma
Children of mothers who took acid-suppressive drugs during pregnancy had a 1.5 times higher incidence of asthma when compared with children who were not exposed to the drugs in utero, finds a large population-based study by researchers at Children’s Hospital Boston. The findings, accompanied by an editorial, appear online in “Early View” in the journal…
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Science & Tech
John P. Holdren named President-elect Obama’s Science Advisor
President-elect Barack Obama today announced that he has selected Harvard’s John P. Holdren to serve as Assistant to the President for Science and Technology in the new administration. The post, popularly known as “the President’s science advisor,” also includes directorship of the Office of Science and Technology Policy in the Executive Office of the President…
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Health
New label-free method tracks molecules and drugs in live cells
A new type of highly sensitive microscopy developed by Harvard researchers could greatly expand the limits of modern biomedical imaging, allowing scientists to track the location of minuscule metabolites and drugs in living cells and tissues without the use of any kind of fluorescent labeling. The technique, based on stimulated Raman scattering (SRS), works by…
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Health
Supply of board-certified emergency physicians unlikely to meet projected needs
The number of physicians with board certification in emergency medicine is unlikely to meet the staffing needs of U.S. emergency departments in the foreseeable future, if ever. In the December issue of Academic Emergency Medicine, the investigators report finding that staffing every emergency department with board-certified emergency physicians does not appear to be feasible, given…
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Health
Hormone therapy for prostate cancer does not appear to increase cardiac deaths
Treating prostate cancer patients with drugs that block hormonal activity does not appear to increase the risk of death from cardiovascular disease, according to a study led by Harvard Medical School researchers at Massachusetts General Hospital. While a 2006 report from members of the same study team found that treatment with gonadotropin-releasing hormone (GnRH) agonists…
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Health
Fresh insight into retinitis pigmentosa
Rods and cones coexist peacefully in healthy retinas. Both types of cells occupy the same layer of tissue and send signals when they detect light, which is the first step in vision. The incurable eye disease retinitis pigmentosa, however, reveals a codependent relationship between the two that can be destructive. When flawed rods begin to…
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Health
Connie Cepko
In some ways, Connie Cepko’s job has gotten easier. The Harvard Medical School genetics professor is working to uncover the mysteries of the eye, to understand how it develops and what can go wrong. Her work ranges from understanding the genetic roots of diseases like retinitis pigmentosa, which afflicts 100,000 Americans, to basic genetic research…
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Health
Another step forward in ALS and stem cell research
A Harvard Stem Cell Institute research team has succeeded in deriving spinal motor neurons from human embryonic stem cells, and has then used them to replicate the Amyotrophic Lateral Sclerosis (ALS) disease process in a laboratory dish.
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Health
Some blood-system stem cells reproduce more slowly than expected
A research collaboration lead by Harvard Stem Cell Institute researchers at Massachusetts General Hospital (MGH) has found a subpopulation of hematopoietic stem cells, which generate all blood and immune system cells, that reproduce much more slowly than previously anticipated. Use of these cells may improve the outcome of stem cell transplants – also called bone…
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Science & Tech
Having happy friends can make you happy
If you’re happy and you know it, thank your friends — and their friends. And while you’re at it, their friends’ friends. But if you’re sad, hold the blame. Researchers from Harvard Medical School and the University of California, San Diego, have found that “happiness” is not the result solely of a cloistered journey filled…
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Health
Common surgical anesthetic induces Alzheimer’s-associated changes in mouse brains
For the first time researchers have shown that a commonly used anesthetic can produce changes associated with Alzheimer’s disease in the brains of living mammals, confirming previous laboratory studies. In their Annals of Neurology report, which has received early online release, a team of Harvard researchers at Massachusetts General Hospital (MGH) shows how administration of…
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Health
Drug trial shows dramatic reduction in risks posed by hidden heart disease
A Harvard-led study shows that the risk of heart attack and stroke among subjects with “silent heart disease” — and normal cholesterol levels — can be dramatically reduced by the use of an already widely prescribed class of drugs.
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Health
C. Ronald Kahn first to win Manpei Suzuki International Prize for Diabetes Research
C. Ronald Kahn, M.D., Mary K. Iacocca Professor of Medicine at Harvard Medical School, and head of the Head Section on Obesity and Hormone Action at the Joslin Diabetes Center, has been named the first winner of the Manpei Suzuki International Prize for Diabetes Research. “Joslin Diabetes Center is delighted that one of our world-renowned…
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Health
Microbiologist Gary Ruvkun:
Gary Ruvkun has made a career out of imagining the unimaginable, and of surrounding himself with like-minded thinkers who let the wheels of thought spin until they catch on something hard, gain traction, and take off. In the early 1990s, the thoughts of Ruvkun and colleague Victor Ambros caught on the idea of microRNA, tiny…
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Health
Survey finds disconnect between sexual problems in women and feeling of distress
The largest such study ever published finds that, although about 40 percent of women surveyed report having sexual problems, only 12 percent indicate that those issues are a source of significant personal distress. The report, led by a Harvard Medical School(HMS) physician at Massachusetts General Hospital (MGH), appears in the current issue of Obstetrics &…
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Health
Gene scan of Alzheimer’s families identifies four new suspect genes
The first family-based genome-wide association study in Alzheimer’s disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the devastating neurological disorder. In their report in the Nov. 7 American Journal of Human Genetics, first released online, a team led by Harvard researchers from…
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Health
Scientists unlock secret of death protein’s activation
Harvard Medical School researchers at Dana-Farber Cancer Institute have identified a previously undetected trigger point on a naturally occurring “death protein” that helps the body get rid of unwanted or diseased cells. They say it may be possible to exploit the newly found trigger as a target for designer drugs that would treat cancer by…
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Health
Volunteers unveil DNA, medical data in push for everyday gene sequencing
The world moved a step deeper into the DNA age yesterday as 10 volunteers released their genetic and medical information on the Internet as part of a multi-year effort to make genetic data an everyday part of medical care. The effort was headed by Harvard Medical School’s George Church, professor of genetics and head of…
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Health
Caffeine not associated with overall breast cancer risk;
Ken Ishitani of Brigham and Women’s Hospital and Harvard Medical School, and Tokyo Women’s Medical University, Japan, and colleagues report in the Oct. 13 issue of Archives of Internal Medicine that caffeine consumption does not appear to be associated with overall breast cancer risk. However, there is a possibility of increased risk for women with…
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Science & Tech
A protein found to restore blood glucose in type 1 diabetes model
A protein made by the liver in response to inflammation and used to treat patients suffering from a genetic form of emphysema has been shown to restore blood glucose levels in a mouse model of type 1 diabetes mellitus, according to a new study led by Harvard Medical School (HMS) researchers at Beth Israel Deaconess…
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Health
Another step forward in cell reprogramming
Imagine, if you can, a day within the next decade when a physician-scientist could remove a skin cell from your arm, and with a few chemicals turn that fully formed adult cell into a dish of stem cells genetically matched to you.
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Science & Tech
Hansjorg Wyss gives $125 million to create institute for biologically inspired engineering
Engineer, entrepreneur, and philanthropist Hansjörg Wyss MBA ’65 has given Harvard University $125 million to create the Hansjörg Wyss Institute for Biologically Inspired Engineering. Investigators at the Wyss Institute (pronounced “Vees”) will strive to uncover the engineering principles that govern living things, and use this knowledge to develop technology solutions for the most pressing healthcare…