The researchers elucidated the role of gut hormones, their effects on metabolism and informed the design of treatments for type 2 diabetes, obesity and short bowel syndrome. The work of Holst, Habener and Drucker propelled the field forward and enabled the design of several new classes of disease-altering treatments.
The three scientists identified a family of glucagon-like peptides in the 1970s and 1980s and since then have led the field of metabolism research, with studies that went from bedside observations to the lab bench and back to the clinic. The discoveries — spanning research in cells, animals and humans — culminated in the development of at least three classes of new medications.
The award recipients are:
- Daniel Drucker, senior scientist at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto, Canada, and professor of medicine at the University of Toronto
- Joel Habener, professor of medicine at Harvard Medical School and director of the Laboratory of Molecular Endocrinology at Massachusetts General Hospital
- Jens Juul Holst, professor of biomedical sciences at the University of Copenhagen, Denmark
The honorees will share a $500,000 prize. The Warren Alpert Foundation, in association with Harvard Medical School, honors scientists whose work has improved the understanding, prevention, treatment or cure of human disease.