Katherine Gregory, a nurse scientist at Brigham and Women’s Hospital, searched for an answer to the mystery of necrotizing enterocolitis (NEC), a sometimes fatal infectious disease of the newborn gut affecting preterm infants.
Two Harvard Stem Cell Institute researchers have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the form of age-related heart failure that affects millions of Americans, a study says.
Harvard School of Public Health-affiliated physicians were among the hospital emergency department staff called upon to care for victims of the explosions ...
According to a study by researchers at Harvard-affiliated Brigham and Women’s Hospital, women who took ibuprofen or acetaminophen two or more days per week had an increased risk of hearing loss.
New research from Brigham and Women’s Hospital (BWH) finds that women with high job strain are more likely to experience a cardiovascular-related event compared with women with low job strain. These findings are published in the open access journal PLoS ONE.
Stem cells being transfused into post-heart attack patients may not be developing into new heart muscle, but they still appear to be beneficial. Some stem cells in the bone marrow, called c-kit+ cells, appear capable of stimulating adult stem cells already present in the heart to repair damaged tissue.
It has long been a given that adult humans — and mammals in general — lack the capacity to grow new nephrons, the kidney’s delicate blood filtering tubules, which has meant that dialysis, and ultimately kidney transplantation, is the only option for the more than 450,000 Americans who have kidney failure.
James Maki, a 59-year-old who became the nation’s second face transplant recipient in April to repair injuries from a horrific subway accident, left Brigham and Women’s Hospital on Thursday (May 21), thankful for what he called a “new chance to build my life.”
Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood. Two groups of Harvard Stem Cell Institute (HSCI) researchers from Children’s Hospital Boston (Children’s) and Brigham and Women’s Hospital (BWH) — presenting multiple lines of evidence from zebrafish, mice, and mouse embryonic stem cells — provide an intriguing answer: A beating heart and blood flow are necessary for development of the blood system, which relies on mechanical stresses to cue its formation.
In a recent sleep study testing alertness and performance in sleep-deprived adults, researchers at Brigham and Women’s Hospital (BWH) determined that healthy older adults handle sleep deprivation better than younger adults. The findings appeared online on May 3, in an advance online edition of the Journal of the American Geriatrics Society.
Surgeons at Harvard-affiliated Brigham and Women’s Hospital toiled in twin operating rooms Thursday (April 9), becoming just the second U.S. team to perform facial transplant surgery.
Michael Aaron Lambert, assistant professor of medicine in Harvard Medical School, received the inaugural Thomas H. Lee M.D. Award for Excellence in Primary Care on April 3. Lambert is the medical director of Southern Jamaica Plain Health Center in Boston.
New technologies now allow surgery to be performed with less impact on patient quality of life. As the trend toward minimally invasive surgery grows, robotic-assisted surgery has become an appealing tool for gynecologic oncology surgeons. However, to date, there is little data to confirm the benefits of this technology. New research from Brigham and Women’s Hospital (BWH) compares robotic radical hysterectomy (RRH) using the DaVinci robot to classically performed open radical hysterectomies (ORH) in patients with stage I and II cervical cancer. Researchers found that RRH results in lower blood loss and shorter length of stay compared with ORH. The findings are available online and published in the December print issue of Gynecologic Oncology.
A Harvard-led study shows that the risk of heart attack and stroke among subjects with “silent heart disease” — and normal cholesterol levels — can be dramatically reduced by the use of an already widely prescribed class of drugs.
The weekend was hectic for physician Rhonda Bentley-Lewis: two full days of activities, including her son’s birthday party. Then came the trip to the emergency room, not to attend to a patient, but to Christian, the 11-year-old birthday boy, and his broken wrist.
At its annual dinner on Sept. 5, the Hippocrates Society honored Harvard Medical School Associate Professor of Medicine Michael VanRooyen with the 2008 Humanitarian Award. VanRooyen, who is also associate professor in the Department of Global Health and Population at the Harvard School of Public Health (HSPH), was recognized for his extensive work in humanitarian assistance in more than 30 countries affected by war and disaster, as well as for his efforts in the United States.
A new genetic finding from a group of researchers at Brigham and Women’s Hospital (BWH), the University of Wisconsin School of Medicine and Public Health (SMPH), and the University of Ottawa may help pave the way for the discovery of therapies that could effectively treat Parkinson’s disease (PD).
Jim Hu and colleagues at Harvard-affiliated Brigham and Women’s Hospital (BWH) assessed surgical utilization and complications, lengths of hospital stay, and cancer outcomes in more than 2,700 men who underwent prostate cancer surgery.
Postmenopausal women taking hormone therapy appear to have an increased risk of stroke regardless of when they started treatment, according to a report in the April 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Assistant Professor of Pathology Charles Lee of Brigham and Women’s Hospital (BWH) has been named the recipient of the 2008 Ho-Am Prize in Medicine.
Many medications are approved by the U.S. Food and Drug Administration (FDA) on the brink of congressionally mandated deadlines, and those drugs are more likely to face later regulatory intervention than those approved with greater deliberation, researchers at Harvard University have found. Drugs fast-tracked by the FDA are more likely to eventually be withdrawn from global markets for safety reasons, undergo manufacturing revisions, or face labeling changes, according to Daniel Carpenter, professor of government in Harvard’s Faculty of Arts and Sciences. The research was published in the March 27 issue of the New England Journal of Medicine.
A relationship has been observed between deep sleep and the ability of the brain to learn specific tasks. Researchers at Harvard-affiliated Brigham and Women’s Hospital (BWH) have now shown that the processes that regulates deep sleep may affect visual learning. These results are published in the March 12 issue of the Journal of Neuroscience.
Researchers at Brigham and Women’s Hospital (BWH), the Harvard School of Public Health (HSPH), Harvard Medical School (HMS) and Partners In Health (PIH) have received a grant of $14 million over five years from the National Institutes of Health to study multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). The goal of the project is to better understand the development and transmission of drug-resistant tuberculosis and to identify practical approaches to reduce the public health burden created by this disease.
It’s increasingly believed among scientists that nearly every cancer contains small populations of highly dangerous cells — cancer stem cells — that can initiate a cancer, drive its progression, and create endless copies of themselves. On the theory that targeting these cells might be an effective therapeutic strategy, researchers around the world have begun isolating stem cells from various kinds of cancers. Now, for the first time, researchers at Children’s Hospital Boston and Brigham and Women’s Hospital (BWH) have found a strategy that selectively targets cancer stem cells for destruction, successfully halting one of the deadliest cancers — melanoma — in mice.
Our biological propensity for keeping awake during the day and sleeping at night makes night work a challenge. Now, researchers at Brigham and Women’s Hospital (BWH) have found that attention is especially affected during the first night shift. This research appears in the Nov. 28 issue of the Public Library of Science One.
Researchers affiliated with the Channing Laboratory at Brigham and Women’s Hospital (BWH) report in the Nov. 12 issue of Archives of Internal Medicine evidence that men who take beta-carotene supplements for 15 years or longer may have less cognitive decline and better verbal memory than those who do not.
New research out of the Channing Laboratory at Brigham and Women’s Hospital (BWH) reports that frequent consumption of foods containing the flavonoid kaempferol, including nonherbal tea and broccoli, was associated with a reduced risk of ovarian cancer.
Researchers at Brigham and Women’s Hospital and the Broad Institute of MIT and Harvard have discovered a gene involved in rheumatoid arthritis, a painful inflammation that affects 2.1 million Americans and which can destroy cartilage and bone within the afflicted joint.
Stem cells apparently try to mend hearts damaged by heart attacks or high blood pressure. But they do not refresh hearts run down by aging. Evidence for this heartening and disheartening news comes from experiments with mice done at Harvard Medical School (HMS) and Brigham and Women’s Hospital in Boston.
Newly identified inherited variants of a single gene increase breast cancer risk for women of European ancestry approximately 20 percent if they carry one copy of the gene and by 60 percent if they carry two copies. These variants, in the FGFR2 (Fibroblast Growth Factor Receptor 2) gene, were found in more than half of the women studied.
For years, pharmaceutical companies have sought to restrict public access to drug safety data collected in clinical trials on the basis that it is proprietary information, arguing that competitors could use that information in the development of their own products. However, a number of recent cases of drugs found to have dangerous side effects after coming to market, such as the anti-inflammatory drug rofecoxib (Vioxx), have raised concerns about safety data being treated as confidential.
Androgen deprivation therapy - one of the most common treatments for prostate cancer - may increase the risk of death from heart disease in patients over age 65, according to a new study by researchers at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and other institutions.
Using data collected from more than 24,000 initially healthy American women, researchers from Brigham and Women's Hospital (BWH) have devised a new Web-based formula called the Reynolds Risk Score that for the first time more accurately predicts risk of heart attack or stroke among women. In addition to usual risk factors like cholesterol, blood pressure, and smoking, the new Reynolds Risk Score adds information on two new factors: family history of heart attack prior to age 60 and blood level of C-reactive protein (CRP), a measure of artery inflammation. Using the new risk assessment tool, the researchers found that nearly 50 percent of women in the study who were estimated to be at "intermediate risk" for heart attack or stroke based on current guidelines were in fact at significantly higher or lower risk levels.
Identifying the mechanisms that control cell life span is one of the more important questions facing stem cell researchers, indeed, all researchers attempting to understand normal and abnormal cell and organ development. So the recent discovery by a Harvard Stem Cell Institute team that a family of well-known transcription factors plays a major role in regulating the life span and longevity of hematopoietic, or blood, stem cells is of particular note. Transcription factors are proteins that participate in the synthesis of RNA using a DNA template.
Scientists have muscled in on a genetic switch that allows mice to run longer and faster. Humans possess the same switch, so the discovery might open new paths to treating muscle-wasting diseases and building better bodies.
An assistant professor of medicine at Harvard has won a $4.1 million "Era of Hope" scholar award from the U.S. Defense Department's Breast Cancer Research Program in support of his cutting-edge, interdisciplinary research aimed at fighting breast and other types of cancer.