Featured series 
Tag: Mutations
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Nation & World
A step forward in DNA base editing
Scientists at Harvard University and the Broad Institute have developed a new class of DNA base editor that can repair the type of mutations that account for half of human disease-associated point mutations. These single-letter mutations are associated with disorders ranging from genetic blindness to sickle-cell anemia to metabolic disorders to cystic fibrosis.
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Nation & World
Making sense of survival
A Harvard study suggests a process known as synergistic epistasis enables humans to survive with an unusually high mutation rate.
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Nation & World
Study signals need to screen genes for stem cell transplants
Research suggests that genetic sequencing technologies should be used to screen for mutated cells in stem cell cultures, so they can be excluded from scientific experiments and clinical therapies.
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Nation & World
A data bank to battle cancer
Researchers at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute are collaborating on a massive, long-term effort to collect and analyze tumor tissue from 10,000 cancer patients annually. The researchers hope the data will enable them to understand better how tumors behave, while providing opportunities to test new therapies.
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Nation & World
It doesn’t add up
An important new finding by Harvard researchers indicates that cellular mutations responsible for an organism’s successful adaptation do not, when combined over time, provide as much benefit as they would individually be expected to provide.
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Nation & World
It all adds up
New mathematical modeling by scientists from Harvard and other institutions reinforces the view of cancer as a complex culmination of many mutations.
