Tag: Michael E. Greenberg
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Health
Middle Eastern families yield intriguing clues to autism
Research involving large Middle Eastern families, sophisticated genetic analysis and groundbreaking neuroscience has implicated a half-dozen new genes in autism. More importantly, it strongly supports the emerging idea that autism stems from disruptions in the brain’s ability to form new connections in response to experience – consistent with autism’s onset during the first year of…
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Health
Protein underlies brain’s response to activity
Experience helps shape the brain, but how that happens – how synapses are remodeled in response to activity – is one of neurobiology’s biggest mysteries. Though axons and dendrites can be easily spotted waxing and waning under the microscope, the molecular middlemen working inside the cell to shape the neuron’s sinewy processes have been much…
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Science & Tech
Tiny RNA molecules fine-tune the brain’s synapses
Non-coding regions of the genome – those that don’t code for proteins – are now known to include important elements that regulate gene activity. Among those elements are microRNAs, tiny, recently discovered RNA molecules that suppress gene expression. Increasing evidence indicates a role for microRNAs in the developing nervous system, and researchers from Children’s Hospital…
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Health
How does the brain reinvent itself?
In order for us to use our minds for memory, for learning, and so forth, our brains must continually reinvent themselves. How do they do it? A Harvard Medical School research team has looked at the complicated interactions within nerve cells of ion channels, peptide hormones, growth factors, and a host of regulatory proteins and…
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Health
How embryonic stem cells become fine-tuned brains
Research by Michael Greenberg, Harvard Medical School professor of neurology at Children’s Hospital, begins to explain how the embryonic brain’s stem cells decide whether to mature into nerve or glial cells as development proceeds. Greenberg and colleagues reported that neurogenin, a protein known to nudge stem cells toward turning into neurons, does so by actively…

