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Tag: Harvard Medical School
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Health
Discovery could aid in therapeutic cloning, clamping down on cancer
“Our focus is to understand the very first few steps that drive a cell to become an intestinal cell instead of a muscle cell,” says Yang Shi, Harvard Medical School associate professor of pathology. Shi and his research team, working with worms, recently found a key molecule, CBP-1, that pushes young embryonic cells to become…
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Lack of protein ApoE in brain may raise Alzheimer’s risk
Brain cells are protected from possible contamination by substances in circulating blood by what is known as “the blood-brain barrier.” Researchers have many questions about precisely how this protective mechanism works. Recently, Harvard Medical Sschool researchers identified a protein that supports the blood-brain barrier. When a molecule, apolipoprotein E (apoE), is absent, the barrier becomes…
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Science & Tech
Minority patients face barriers to optimum end-of-life care
Eric Krakauer is an instructor in medicine at Harvard Medical School and part of Massachusetts General Hospital’s Palliative Care Service. He and his colleagues have been concerned that, according to many national studies, minorities do not receive the same level of health care that non-minorities do. This is particularly true in the area of what…
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Study adds to the understanding of musical pitch perception
There are differences in the sounds of two voices or two musical instruments even if they hit the same note, and somehow the brain knows that. A new study shows that the auditory cortex, an area of the brain that interprets sound, is important for frequency processing and pitch perception. The research findings, published in…
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Study upends earlier thinking about immune cell’s readiness against disease
A type of disease-fighting cells in the body — T cells — have a reputation for being ever-ready to fight invading infections. But that’s not the way they really work, found Vassiliki Boussiotis, an assistant professor at Harvard Medical School and a researcher at Dana-Farber Cancer Institute in Boston. Boussiotis and her colleagues found that…
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Study finds embryonic stem cells can repair heart muscle
Heart failure develops when the heart stops pumping effectively due to the destruction of muscle cells, known as cardiomyocytes. Damage inflicted during a heart attack causes massive loss of cardiomyocytes, resulting in ventricular dysfunction. Although heart transplantation has proven very successful, only a small number of organs are actually available for transplant each year. That’s…
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Pain and pleasure activate same brain structures
David Borsook is a Harvard Medical School associate professor of radiology, who both treats patients and conducts research. “Over 15 years of seeing patients with pain it became obvious that we do not have good methods of assessing chronic pain,” Borsook says. “And we do not have good methods for treating it.” So Borsook and…
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Science & Tech
Diagnosis by database shows promise
A relatively new approach to researching cancer involves looking at the actions of thousands of genes in cancer tumors. This technique just recently became possible because, using new applications of technology, researchers are able to make “diagnoses by database.” At Harvard Medical School, several teams of researchers have recently discovered new types of cancer or…
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Technique enables quick accounting of gene function
Now that whole genomes have been sequenced, a group of scientists has geared up for the next phase: identification and classification of newly discovered coding regions. The DNA microchip, developed just a few years ago, has already become a standard tool in the geneticist’s repertoire. With genomic sequence in hand, the researcher can synthesize all…
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Polarity gene yields clues to organization of cell signaling, structural growth
Researchers are beginning to understand how a gene called “stardust” works to set up the basic top-down architecture of the epithelial cells that line the gut, skin, and many other organs of an embryo. Working with Norbert Perrimon, Harvard Medical School (HMS) professor of genetics, Beth Stronach, HMS research fellow in genetics, has cloned the…
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Lithium drugs found to reduce suicide risk
Researchers who wondered about the effectiveness of lithium drugs in treating patients with severe depression analyzed 22 studies involving 5,647 patients. The scientists, working at Harvard-affiliated McLean Hospital in Belmont, found through their analysis that those who took the drug showed a nine-fold lower rate of suicide compared to those who did not. “The evidence…
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Science & Tech
Scientists using gene chips identify unique form of leukemia
Currently, physicians diagnose and treat a rare form of cancer that strikes infants as a particularly aggressive form of the more common acute lymphoblastic leukemia. The cancer may respond to chemotherapy at first, but it tends to recur fatally. That’s why the prognosis is so much worse than for most types of childhood leukemia, which…
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Health
Early exposure to Ritalin may blunt desire for cocaine later in life
There are several controversies surrounding the use of Ritalin, or methylphenidate, a stimulant prescribed for children who have an abnormally high level of activity or attention deficit hyperactivity disorder (ADHD). While Ritalin appears to calm hyperactive children, some worry that it may lead to the abuse of other drugs later in life. However, in a…
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Health
Comprehensive set of vision genes discovered
Using a computer program that compares bits of genetic material taken from tissue in the retinas of mice against records in a huge genetic data base from the mouse and human genome project, Harvard Medical School researchers identified approximately 300 photoreceptor genes. That is five times the number of retinal genes that were previously known.…
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“Commoner” in brain crowns the cortex
With its role in higher cognitive functions, the cortex represents a significant evolutionary development in mammals, culminating in the enlarged hemispheres of humans and other primates. In the development of this crowning structure, neurons are guided by factors that are both genetic and environmental. A research team led by Christopher A. Walsh, the Bullard professor…
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The fruit fly fight club
Fruit flies fight. The males will go after each other, fighting to establish dominance. Edward Kravitz, the George Packer Berry professor of neurobiology at Harvard Medical School, is using the fighting fruit fly model system to explore the neurobiology of aggression. Previously Kravitz has used fighting lobsters to study changes in the brain that occur…
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Immune system discovery may lead to preventive therapy for diabetes
The job of cells known as iNKT cells is to regulate the immune system’s response to infections and other disorders, ensuring that only diseased tissue, not healthy tissue, is targeted for attack. Type I diabetes, an “autoimmune” disorder, occurs when the immune system mistakenly attacks healthy insulin-producing cells in the pancreas. A new study involved…
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No innocent bystanders
When cancer cells begin to do their destructive work, they have accomplices — normal cells that help nourish the cancerous ones. As Jack Lawler, Harvard Medical School associate professor of pathology at Beth Israel Deaconess, puts it, there are no innocent bystanders in the process. “Previous research focused on the genetics of the cancer cell,”…
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Cell protein potently blocks enzyme linked to cancer
The ends of chromosomes in normal cells eventually unravel, causing the cells to die. This does not happen in cancer cells, however. Cancer cells use an enzyme named telomerase to rebuild the chromosome ends, which are called telomeres, in essence making cancer cells immortal. Since the discovery of the link between telomerase and cancer, scientists…
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Dopamine may play dual role in Parkinson’s disease
According to the Parkinson’s Disease Foundation, “Parkinson’s disease (PD) is a disorder of the central nervous system that affects between one and one-and-a-half million Americans. Because it is not contagious and does not have to be reported by physicians, the incidence of the disease is often underestimated. PD may appear at any age, but it…
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Health
WHO report reviews world mental health care
Since the mid-1970s, World Health Organization policies have encouraged integrating mental health services into primary care settings. But no one knows what, if anything, might be working to help those who are suffering, says the author of a report reviewing mental health services — or rather, the lack of them — in developing countries. Alex…
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How does the brain reinvent itself?
In order for us to use our minds for memory, for learning, and so forth, our brains must continually reinvent themselves. How do they do it? A Harvard Medical School research team has looked at the complicated interactions within nerve cells of ion channels, peptide hormones, growth factors, and a host of regulatory proteins and…
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Health
Anthrax toxin receptor discovered
The first point of contact between anthrax toxin that invades the body and the cells that the toxin will eventually destroy is a protein, known as a “docking” protein or receptor. This docking protein was recently discovered by researchers at Harvard Medical School and the University of Wisconsin Medical School. Their discovery will, they hope,…
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Cognition unaffected by marijuana use
Harrison Pope, a Harvard professor of psychiatry, and his colleagues at McLean Hospital, a Harvard-affiliated psychiatric facility in Belmont, Mass., investigated the long-term cognitive effects of smoking marijuana. They recruited 180 people, who ranged from light to heavy users. Heavy use was defined as smoking pot at least 5,000 times. All the research subjects took…
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Health
Cardiovascular risks seen from marathon running
Researchers analyzed the blood of marathon runners less than 24 hours after they had finished a race. They found abnormally high levels of inflammatory and clotting factors of the kind that are known to set the stage for heart attacks. “My concern is for people who exercise thinking ‘more is better,’ and that marathon running…
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Health
Anthrax immunity gene found in mice
Anthrax is an often fatal disease that is caused by a bacterium. It has been considered a prime biological weapon in the arsenal of terrorists since attacks in the United States in October 2001 and reports elsewhere of anthrax spores being sent through the mail. Harvard Medical School researchers have identified a gene in mice…
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Health
A strategy to neutralize anthrax toxin in the body
A Harvard Medical School research team has developed a strategy to neutralize anthrax toxin in the body. So far they have tried the treatment in rats. Normally, rats die within hours after being injected with anthrax toxin. But when the toxin was followed minutes later with an injection of an inhibiting agent known as a…
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Researchers identify genes that trigger depression
A substance known as CREB controls gene expression in the brain. It also appears to be active in mood disorders. A group of Harvard researchers at McLean Hospital in Belmont, Mass., have developed methods that allowed them to selectively activate or deactivate CREB in the brains of rats. They found that activation of CREB in…