Featured series 
Tag: Harvard Medical School
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Health
Researchers find a gene for fear
A team of researchers from Harvard, Columbia, and Rutgers universities has found the seat of fear. It’s located in a pea-sized area deep in the brain of all mammals, from gerbils, to lions, to humans. And it’s involved in both inborn fear and the dread we acquire from dealing with people and things that hurt…
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Study suggests obesity has lesser financial impact on African-Americans
The study published in the January 2005 issue of the American Journal of Public Health is among the first to examine how patient demographic factors affect the relationship between body mass index (BMI) and health-care costs. “From the perspective of the health-care system, obesity may be less costly among African-Americans than among whites,” says Christina…
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Faulty gene signaling could lead to development of Crohn’s disease
According to the study’s lead author, Brigham Women’s Hospital’s Derek W. Abbott, “The discovery of this faulty signaling process is a first step in helping us understand and ultimately address the underlying mechanism that causes Crohn’s disease to develop.
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Study finds that both weight and exercise are key to longevity
Over 115,000 participants who were free of cardiovascular disease or cancer, who were between the ages of 30 and 55 and had filled out biennial health and lifestyle questionnaires between 1976 and 2000, were chosen for the study from the Brigham and Women’s Hospital-based Nurses’ Health Study. The women answered questionnaires that asked on average…
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Campus & Community
Ninety percent of U.S. wounded survive
For an article in the Dec. 9, 2004 issue of the New England Journal of Medicine, Atul Gawande, an assistant professor at Harvard Medical School and a surgeon at Brigham and Women’s Hospital in Boston, gathered data on casualties and talked with surgical teams that served near the front lines in Iraq. He concludes that…
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Researchers find high levels of potentially toxic heavy metals in herbal medicine products
“This study, yet again, highlights the need for Congress to revisit the way dietary supplements are regulated in the U.S.,” said co- author David Eisenberg, MD, the Bernard Osher Associate Professor of Medicine and Director of the Harvard Medical School Division of Research and Education in Complementary and Integrative Medical Therapies. “Over-the-counter herbs and supplements…
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Health
Study finds women hesitant to take tamoxifen as preventive measure
“Our study underscores the need [for medical professionals] to address psychological factors that may influence decision- making, in order to help women feel confident and satisfied with their treatment choice,” says the study’s lead author, Sharon Bober, PhD, staff psychologist at Beth Israel Deaconess Medical Center (BIDMC) and Dana-Farber Cancer Institute (DFCI) and clinical instructor…
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Campus & Community
Discovering how we appreciate a loss
A committee of psychiatrists, surgeons, ethicists, and others decided that the only course left for five people with otherwise untreatable mental disorders was to cut out a certain area of their brains. The region sits near the middle of the brain tucked between regions that have to do with thinking and emotion. It is known…
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Health
Sudden death among military personnel often caused by exercise and an identifiable cardiac abnormality
According to the study’s lead author BWH’s Robert E. Eckart, D.O., they had expected that most of the sudden deaths would stem from structural heart abnormalities, but that in actuality, a large number of the deaths defied this theory and could not be identified by today’s screening methods. “The findings suggest genetic abnormalities that affect…
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Grandkids can make you sick
A study by researchers from the Harvard School of Public Health and Harvard Medical School shows that women who care for grandchildren more than nine hours a week have a 55 percent greater chance of developing coronary heart disease than those women who don’t provide such care. Though the study didn’t probe the reasons behind…
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Health
Drugs are effective against eye disease
Results of two large international clinical trials have shown positive results using Macugen, an experimental treatment that targets the abnormal blood vessels found in the “wet” form of macular degeneration. The results, described in November 2003 at the American Academy of Ophthalmology’s annual meeting in Anaheim, Calif., demonstrated the drug’s ability to decrease vision loss.…
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Health
Gene expression profiling helps in ovarian cancer prognosis
Steven A. Cannistra, M.D., director of Gynecologic Medical Oncology at BIDMC and associate professor of medicine at Harvard Medical School, says ovarian cancer is often not detectable until its later stages. At that point, he adds, doctors typically use clinical data to assess a patient’s prognosis and determine her course of therapy, a method that…
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Health
Studies demonstrate positive data in treatment of hepatitis C
Presented by Nezam Afdhal, M.D., chief of Hepatology at Beth Israel Deaconess Medical Center (BIDMC) and associate professor of medicine at Harvard Medical School, the new findings demonstrate promising results for hepatitis C patients who have not responded to existing therapies. According to Afdhal, the most recent advance in treatment has been the pegylation of…
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Health
Risk of becoming resistant to antibiotics may be lower than expected for chronic sinus infection sufferers
“This study was designed to help determine how great a risk antibiotic resistance was among chronic sinus patients to determine if there is a need to re-evaluate how we diagnose and treat the condition. Interestingly, our research shows that patients suffering from chronic sinus infections may be able to lower their rate and likelihood of…
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Health
Study finds that blacks are significantly less likely to undergo prostate cancer screening
In a study involving more than 67,000 men age 65 years and older, the researchers found that blacks were 35 percent less likely than whites to undergo prostate-specific antigen (PSA) testing. The American Cancer Society estimates that nearly 30,000 men will die from prostate cancer this year and that 230,000 cases will be diagnosed. The…
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Health
Study says therapy better than pills in treating sleep-onset insomnia
The findings show non-drug techniques yield better short- and long-term results than the most widely prescribed sleeping pill, zolpidem, commonly known as Ambien. “Sleeping pills are the most frequent treatment for insomnia, yet CBT techniques clearly were more successful in helping the majority of study participants to become normal sleepers,” said study leader Gregg Jacobs.…
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Campus & Community
Appetite hormone restores fertility
A hormone called leptin has been trumpeted as an appetite suppressor and a possible treatment for obesity. New research shows that “a clear connection also exists between fat, or energy storage, and the ability to reproduce,” says Corrine Welt, an assistant professor of medicine who works at Massachusetts General Hospital, a Harvard affiliate. The women…
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Campus & Community
Probing inappropriate rage
As 30 research subjects seethed, scientists measured blood flowing between the thinking and emotional parts of their brains. What would be the difference between people who controlled their anger pretty well, and those who could not handle it in a socially acceptable way? These were the first such brain scans ever done with mental patients…
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Health
Surprising variations discovered in human genomes
Researchers from Harvard Medical School and the University of Toronto in Canada looked at 55 healthy, unrelated men and women, and they discovered 255 regions with relatively large gains or losses in their DNA. “We were extraordinarily surprised to see that some people have so much more or less DNA,” says Charles Lee, a geneticist…
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Health
Images reveal how leading cause of severe childhood diarrhea enters cells
The work illustrates how vaccine development can advance by probing the physical architecture of viruses and finding the parts needed to prime the immune system. Rotavirus, which causes severe diarrhea and vomiting, infects most children, causes gastroenteritis that sometimes requires hospitalization, and kills about 440,000 children each year. The only licensed vaccine, RotaShield, was discontinued…
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Health
Drug-coated stents don’t save money but are reasonably cost-effective, study shows
Treatment with the Cypher sirolimus-coated stent, developed by Johnson & Johnson’s Cordis division, cost approximately $2,900 more per patient compared to the use of bare metal stents. The drug is designed to prevent restinosis, where a blood vessel cleared of an obstruction begins to close back up again. Even after factoring in other costs associated…
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Health
Study yields insights into precancerous condition
Caused by a mutation that inactivates the tumor suppressor gene LKB1, PJS causes gastrointestinal polyps that have a 30 to 50 percent chance of becoming cancerous, says senior author Lewis Cantley, PhD, chief of the Division of Signal Transduction at Beth Israel Deaconess Medical Center (BIDMC) and a member of the Department of Systems Biology…
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Health
Stem cell science
“Stem-cell transplants are already performed every day in Harvard-affiliated hospitals — and around the world,” says Harvard Stem Cell Initiative codirector David Scadden, professor of medicine at Harvard Medical School and director of the Center for Regenerative Medicine at Massachusetts General Hospital. So-called bone-marrow transplants, which transfer tens of thousands of cells of many different…
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Health
Quality of life continues to change long-term after treatment for prostate cancer
Researchers compared outcomes for men who had undergone surgery or radiation in the first study to look at the effects of prostate cancer treatment on quality of life beyond five years after treatment. Researchers surveyed 1,008 men with and without a history of prostate cancer about quality of life issues. The participants with prostate cancer…
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Newly identified gene linked to brain development
Bilateral frontoparietal polymicrogyria (BFPP) is a recessive genetic disorder resulting in severely abnormal architecture of the brain’s frontal lobes, as well as milder involvement of parietal and posterior parts of the cerebral cortex, which is “the part of the brain that distinguishes humans from other species,” says the study’s senior author, Christopher A. Walsh, M.D.,…
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Health
Many have ‘cancer,’ but few progress to true disease
Folkman and Kalluri suggest that most tumors don’t develop a blood supply that allows them to grow and progress to cancer, because people produce natural inhibitors of blood vessel growth, or angiogenesis. They write that a better understanding of these inhibitors may yield a new generation of nontoxic anticancer drugs that could be given preventively…
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Health
Study finds no direct links between testosterone therapy, diseases
A comprehensive review of 72 studies addresses the current controversy about testosterone replacement therapy and its potential health risks to men. “We reviewed decades of research and found no compelling evidence that testosterone replacement therapy increases the incidence of prostate cancer or cardiovascular disease,” said Abraham Morgentaler, a urologist at Beth Israel Deaconess Medical Center…
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Campus & Community
3-D images reveal key step in viral entry into cells
Work published in the Jan. 22, 2004, issue of Nature is a significant advance in the understanding of how viruses cause infection, and offers two possible strategies for blocking these infections with antiviral drugs or vaccines. The research involved a major category of viruses known as “enveloped” viruses, so called because of their fatty outer…
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Health
Idea inspires new screening test for anti-cancer agents
In a study published in the December 2003 issue of Cell, investigators from Dana-Farber Cancer Institute demonstrated that a new technique has helped them to identify a class of existing drugs able to kill certain types of cancer cells. “This is an example where one person’s work – that of Bill Sellers [of Medical Oncology]…
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Health
For-profit health plans did not restrict Medicare beneficiaries’ use of high-cost operative procedures
Testing the hypothesis that rates of use of 12 high-cost procedures would be lower in for-profit health plans than in not-for-profit plans, researchers analyzed Medicare HEDIS (Health Plan Employer Data and Information Set) data on more than 3.7 million Medicare beneficiaries 65 years of age or older who were enrolled in 254 health plans in…