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Tag: Christopher A. Walsh
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Health
Middle Eastern families yield intriguing clues to autism
Research involving large Middle Eastern families, sophisticated genetic analysis and groundbreaking neuroscience has implicated a half-dozen new genes in autism. More importantly, it strongly supports the emerging idea that autism stems from disruptions in the brain’s ability to form new connections in response to experience – consistent with autism’s onset during the first year of…
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Health
Slow reading in dyslexia tied to disorganized brain tracts
Dyslexia marked by poor reading fluency — slow and choppy reading — may be caused by disorganized, meandering tracts of nerve fibers in the brain, according to researchers at Children’s Hospital Boston, Beth Israel Deaconess Medical Center (BIDMC), and the Harvard Graduate School of Education (HGSE) at the time the work was done. Their study,…
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Health
Gene clue to brain asymmetry revealed on right side
Although many assumed that the asymmetry-producing genes, when found, would be more highly expressed on the left side of the brain than the right, Sun Tao, Christopher A. Walsh, and their colleagues found otherwise. One gene, LMO4, that showed the most consistent difference was much more highly expressed on the right. The researchers found that…
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Health
Newly identified gene linked to brain development
Bilateral frontoparietal polymicrogyria (BFPP) is a recessive genetic disorder resulting in severely abnormal architecture of the brain’s frontal lobes, as well as milder involvement of parietal and posterior parts of the cerebral cortex, which is “the part of the brain that distinguishes humans from other species,” says the study’s senior author, Christopher A. Walsh, M.D.,…
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Health
Genes found that regulate brain size
A gene that builds bigger brains, called beta-catenin, was discovered in the laboratory of Christopher A. Walsh, Bullard Professor of Neurology at Harvard Medical School. Researchers there engineered increased activity into the beta-catenin gene in mice, and the mice brains grew to almost twice the usual size. Not only that, but the cerebral cortex, seat…
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Health
“Commoner” in brain crowns the cortex
With its role in higher cognitive functions, the cortex represents a significant evolutionary development in mammals, culminating in the enlarged hemispheres of humans and other primates. In the development of this crowning structure, neurons are guided by factors that are both genetic and environmental. A research team led by Christopher A. Walsh, the Bullard professor…