Harvard researchers have found a gene therapy that delivers a protein that suppresses the development of female reproductive organs. This new treatment could improve the survival of patients with ovarian cancer that has recurred after chemotherapy. Recurrence happens 70 percent of the time and is invariably fatal.
Treatment with inhaled nitric oxide (NO) has proved to be lifesaving in newborns, children, and adults with several dangerous conditions. But the availability of the treatment has been limited by the size, weight, and complexity of equipment needed to administer the gas, and the therapy’s high price — until now.
A new test can accurately diagnose the Ebola virus disease within minutes at the point of care.
Afamefuna Nduaguba, a Nigerian immigrant, overcame early struggles at Roxbury Community College to gain a bachelor’s degree from the University of Massachusetts, Boston, and now an M.D. from Harvard Medical School.
Lara Phillips, a Harvard Medical School instructor in emergency medicine, was in Nepal during the April 25 earthquake that devastated Kathmandu and other areas. She and colleagues have traveled from the high-mountain clinic where they worked to offer assistance.
Renee Salas, a Wilderness Medicine Fellow from Harvard-affiliated Massachusetts General Hospital and Harvard Medical School instructor in emergency medicine, was working at a remote clinic near the Mount Everest Base Camp when Saturday’s earthquake struck Nepal. She shared her experience with the Gazette.
With Nepal struggling to grasp the enormous calamity caused by the magnitude 7.8 earthquake that struck north of Kathmandu Saturday, Harvard is mobilizing to help with technical and medical assistance and reaching out to faculty, staff, and students visiting the region.
Harvard Stem Cell Institute researchers at Massachusetts General Hospital have developed an “imageable” mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study, published online in the journal Brain, also describes a strategy for preventing the potential negative consequences of stem cell therapy.
New research from Harvard and MIT shows that different cognitive skills peak at different times in lifespan.
Harvard Medical School and Massachusetts General Hospital Professor Emery N. Brown, who also holds appointments at the Massachusetts Institute of Technology, was named to the National Academy of Engineering in early February.
Harvard psychiatrist Jacqueline Olds offers some tips for coping with the snow and the dark days of winter.
Imaging study finds the first evidence of neuroinflammation in brains of chronic pain patients, which could lead to new, targeted treatments.
Framingham Heart Study, PNAS Early Edition, Harvard Medical School Investigators working to unravel the impact of genetics versus environment on traits such as obesity may also need to consider a new factor: when individuals were born.
Harvard will partner with Massachusetts General Hospital, Massachusetts Institute of Technology, and The Boston Globe for a new, weeklong festival of big ideas and bold solutions next October.
Harvard Stem Cell Institute researchers have taken what they describe as “the first step toward a pill that can replace the treadmill” for the control of obesity.
Harvard-affiliated researchers have found that a monthlong residential program could be better than standard-of-care outpatient programs in helping young adults stay drug-free.
Investigators at the Harvard-affiliated Massachusetts General Hospital have developed a system to accurately track the dynamic process of falling asleep, something that has not been possible with existing techniques.
Harvard Stem Cell Institute researchers at Massachusetts General and Boston Children’s hospitals for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
A small study from a group of Harvard-affiliated researchers at Massachusetts General Hospital investigates differences in how important brain structures are activated when women view images of their own children and their dogs.
Three nonprofits with strong Harvard ties have joined forces at the front lines of the Ebola epidemic in West Africa.
Harvard researchers working at the Broad Institute of MIT and Harvard have uncovered nine rare genetic mutations that dramatically increase the risk of developing type 2 diabetes. The discovery of the mutations highlights the dizzying genetic diversity of a disease rapidly spreading around the world.
A new device inspired by the human spleen and developed by a team at Harvard’s Wyss Institute for Biologically Inspired Engineering may radically transform the way doctors treat sepsis.
A Harvard Stem Cell Institute study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant of shifts in their energy supply than their normal counterparts. The results suggest there could be ways to target and kill cancer cells without affecting healthy cells.
The protective gear needed to get Sierra Leone’s health clinics reopened, coupled with public education about the Ebola epidemic, are the greatest areas of need, according to a Harvard Fulbright Fellow and physician from Sierra Leone.
Studies begun by Harvard Stem Cell Institute scientists eight years ago have led to a report that may be a major step in developing treatments for amyotrophic lateral sclerosis, or Lou Gehrig’s disease.
To David Altshuler, the recent discovery of a genetic mutation that protects against type 2 diabetes offers hope in fighting more than just diabetes. It ...
A new study found that two-child families present five times more risk of sibling obesity than single-child homes with an obese parent, which doubles the risk. Obesity risk is even stronger among same-gender siblings.
The Harvard Stem Cell Institute is now 10 years old. What began as an idea embracing cross-disciplinary research quickly became a generator of scientific discoveries.
Fraternal twins Rosh and Roshan Sethi have shared much of their lives, including at Yale as undergraduates and sharing an apartment while enrolled at Harvard Medical School. Now preparing to graduate, they’re anticipating diverging careers, with Roshan exploring radiation oncology and Rosh head and neck surgery.
Harvard stem cell scientists have discovered that a recently approved medication for epilepsy might be a meaningful treatment for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder.
Investigators at Harvard-affiliated Massachusetts General Hospital (MGH) may have found a way to solve a problem that has plagued ligand-mimicking integrin inhibitors, a group of drugs that have the potential to treat conditions ranging from heart attacks to cancer metastasis.
A multi-institutional study led by investigators from Massachusetts General Hospital and the Broad Institute of Harvard and MIT reports that newly diagnosed Crohn’s disease patients show increased levels of harmful bacteria and reduced levels of the beneficial bacteria usually found in a healthy gastrointestinal tract.
A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost-effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma.
Researchers at the Broad Institute and Massachusetts General Hospital, both Harvard affiliates, have identified mutations in a gene that can reduce the risk of individuals developing type 2 diabetes. If a drug can be developed that mimics the protective effect of these mutations, it could open up new ways of preventing this devastating disease.
The first clinical trial of a drug intended to delay the onset of symptoms of Huntington’s disease (HD) reveals that high-dose treatment with the nutritional supplement creatine was safe and well tolerated by most study participants. Neuroimaging also showed a treatment-associated slowing of regional brain atrophy, evidence that creatine might slow the progression of presymptomatic HD.
HIV antiviral therapy lets infected people live relatively healthy lives for many years, but the virus doesn’t go away completely. If treatment stops, the virus multiplies again from hidden reservoirs in the body. Researchers may have found HIV’s viral hiding place — in a small group of recently identified T cells with stem cell-like properties.
Using color-coded labels to mark healthier foods and then displaying them more prominently appears to have prompted customers to make more healthful long-term dining choices in their large hospital cafeteria, according to a report from Harvard-affiliated Massachusetts General Hospital
A Massachusetts General Hospital-led research team of Harvard affiliates has identified an immune cell protein that is critical to setting off the body’s initial response against viral infection.
A drug approved for the treatment of rheumatoid arthritis may also turn out to be the first targeted therapy for one of the most common forms of kidney disease, a condition that almost inevitably leads to kidney failure.
Two new books from Harvard Health Publications are aimed at people who have more than normal levels of anxiety and depression but fall short of clinical definitions.
A simple, color-coded system for labeling food items in a hospital cafeteria appears to increase customers’ attention to the nutritional value of their food choices, and encourage the purchase of the healthiest items.
They began with a discovery in zebrafish in 2007, and now researchers at the Harvard Stem Cell Institute (HSCI) have published initial results of a Phase Ib human clinical trial of a therapeutic that could improve the success of blood stem cell transplantation. This marks the first time that HSCI has carried a discovery from the lab bench to the clinic.
After the U.S. Centers for Disease Control and Prevention issued a report on the threat from drug-resistant bacteria, David Hooper, a physician at Massachusetts General Hospital and an authority on the subject, discussed the issues during a question-and-answer session.
Jessica Meir, an assistant professor of anesthesia at Harvard Medical School and Massachusetts General Hospital, is the latest member of the Harvard community given a chance to head to space, joining moon-walkers and Hubble Space Telescope repairmen as she trains to become a NASA astronaut.
About half of a small group of patients with fibromyalgia — a common syndrome that causes chronic pain and other symptoms — were found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy.
Amy Wagers and Emmanuelle Passegué have found that cancer stem cells actively remodel the environment of bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants.
Specialists examines the country's obesity problem from several angles at an HMS-MGH forum.
Founding donor Hansjörg Wyss doubled his gift to Harvard’s Wyss Institute for Biologically Inspired Engineering from $125 million to $250 million to the University to further advance the institute’s pioneering work.
In a study conducted by Harvard and MGH researchers, gut microbes of mice underwent drastic changes following gastric bypass surgery, and transfer of the microbes into sterile mice resulted in rapid weight loss.
A novel experiment illuminates the importance of the doctor-patient relationship, providing the first data into the underlying neurobiology of the caregiver.