Harvard stem cell scientists have discovered that a recently approved medication for epilepsy might be a meaningful treatment for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder.
Investigators at Harvard-affiliated Massachusetts General Hospital (MGH) may have found a way to solve a problem that has plagued ligand-mimicking integrin inhibitors, a group of drugs that have the potential to treat conditions ranging from heart attacks to cancer metastasis.
A multi-institutional study led by investigators from Massachusetts General Hospital and the Broad Institute of Harvard and MIT reports that newly diagnosed Crohn’s disease patients show increased levels of harmful bacteria and reduced levels of the beneficial bacteria usually found in a healthy gastrointestinal tract.
A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost-effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma.
Researchers at the Broad Institute and Massachusetts General Hospital, both Harvard affiliates, have identified mutations in a gene that can reduce the risk of individuals developing type 2 diabetes. If a drug can be developed that mimics the protective effect of these mutations, it could open up new ways of preventing this devastating disease.
The first clinical trial of a drug intended to delay the onset of symptoms of Huntington’s disease (HD) reveals that high-dose treatment with the nutritional supplement creatine was safe and well tolerated by most study participants. Neuroimaging also showed a treatment-associated slowing of regional brain atrophy, evidence that creatine might slow the progression of presymptomatic HD.
HIV antiviral therapy lets infected people live relatively healthy lives for many years, but the virus doesn’t go away completely. If treatment stops, the virus multiplies again from hidden reservoirs in the body. Researchers may have found HIV’s viral hiding place — in a small group of recently identified T cells with stem cell-like properties.
Using color-coded labels to mark healthier foods and then displaying them more prominently appears to have prompted customers to make more healthful long-term dining choices in their large hospital cafeteria, according to a report from Harvard-affiliated Massachusetts General Hospital
A Massachusetts General Hospital-led research team of Harvard affiliates has identified an immune cell protein that is critical to setting off the body’s initial response against viral infection.
A drug approved for the treatment of rheumatoid arthritis may also turn out to be the first targeted therapy for one of the most common forms of kidney disease, a condition that almost inevitably leads to kidney failure.
Two new books from Harvard Health Publications are aimed at people who have more than normal levels of anxiety and depression but fall short of clinical definitions.
A simple, color-coded system for labeling food items in a hospital cafeteria appears to increase customers’ attention to the nutritional value of their food choices, and encourage the purchase of the healthiest items.
They began with a discovery in zebrafish in 2007, and now researchers at the Harvard Stem Cell Institute (HSCI) have published initial results of a Phase Ib human clinical trial of a therapeutic that could improve the success of blood stem cell transplantation. This marks the first time that HSCI has carried a discovery from the lab bench to the clinic.
After the U.S. Centers for Disease Control and Prevention issued a report on the threat from drug-resistant bacteria, David Hooper, a physician at Massachusetts General Hospital and an authority on the subject, discussed the issues during a question-and-answer session.
Jessica Meir, an assistant professor of anesthesia at Harvard Medical School and Massachusetts General Hospital, is the latest member of the Harvard community given a chance to head to space, joining moon-walkers and Hubble Space Telescope repairmen as she trains to become a NASA astronaut.
About half of a small group of patients with fibromyalgia — a common syndrome that causes chronic pain and other symptoms — were found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy.
Amy Wagers and Emmanuelle Passegué have found that cancer stem cells actively remodel the environment of bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants.
Specialists examines the country's obesity problem from several angles at an HMS-MGH forum.
Founding donor Hansjörg Wyss doubled his gift to Harvard’s Wyss Institute for Biologically Inspired Engineering from $125 million to $250 million to the University to further advance the institute’s pioneering work.
In a study conducted by Harvard and MGH researchers, gut microbes of mice underwent drastic changes following gastric bypass surgery, and transfer of the microbes into sterile mice resulted in rapid weight loss.
A novel experiment illuminates the importance of the doctor-patient relationship, providing the first data into the underlying neurobiology of the caregiver.
he National Football League Players Association (NFLPA) has awarded Harvard Medical School a $100 million grant to create a transformative 10-year initiative — Harvard Integrated Program to Protect and Improve the Health of NFLPA Members.
More than a third of U.S. physicians responding to a national survey indicated they prescribed brand-name drugs when appropriate generic substitutes were available.
A new study finds differences in the ways that participation in Alcoholics Anonymous helps men and women maintain sobriety.
When Madeline Meehan makes her annual donation to Harvard Community Gifts, she won't just be providing handmade blankets to sick children, she’ll also be helping her mother’s labor of love. This is one of a series of Gazette articles highlighting some of the many initiatives and charities the can be supported through the Harvard Community Gifts campaign.
A Harvard panel examined the problem of clinics around the world that provide stem cell treatments for intractable conditions. Although there is no medical evidence of the treatments’ effectiveness, such clinics have drawn thousands of patients from many countries.
A new study has found that participating in an eight-week meditation training program can have measurable effects on how the brain functions even when someone is not actively meditating.
Harvard researchers have worked for years to understand better the familiar mystery of sleep, highlighting not only what happens when we close our eyes, but also the effects on us when we don’t.
Researchers find that they have the necessary starting material to understand the pathways that contribute to Crohn’s disease and ulcerative colitis, and they also have a framework to better appreciate that these may not be two distinct diseases, but rather collections of many different diseases.
Medical experts are coming to see cancer not as a disease of cells or even of genes, but as an “organismal disease,” Siddhartha Mukherjee, author of the Pulitzer Prize–winning cancer history “The Emperor of All Maladies,” told a Harvard Medical School audience on Oct. 11.
A Harvard study of sports programs at Brown University, Dartmouth College, and Virginia Tech finds that the way the head injury commonly called concussion is usually diagnosed varies greatly and may not be the best way to determine who is at risk for future problems.
A recipient of this year’s Nobel Prize in chemistry investigated the workings of cell receptors, the basis of his groundbreaking research involving the complex process of how the body’s cells communicate and interact, while a young medical resident at Harvard.
A new study describes the mechanism behind impaired muscle repair during aging and a strategy that may help rejuvenate aging tissue by manipulating the environment in which muscle stem cells reside.
In research, treatment, and outreach, researchers from Harvard Medical School are taking on the childhood obesity epidemic in the United States. This is the first in a three-part series.
Most of the DNA alterations that are tied to disease do not alter protein-coding genes, but rather the “switches” that control them. Characterizing these switches is one of many goals of the Encyclopedia of DNA Elements (ENCODE) project.
Researcher Biju Parekkadan is developing devices that employ cell therapy to help people with organ failure.
A study led by Harvard researchers of Mongolian schoolchildren supports the possibility that daily vitamin D supplementation can reduce the risk of respiratory infections in winter.
Some women’s vulnerability to anxiety and mood disorders may be explained by their estrogen levels, according to new research by Harvard and Emory University neuroscientists.
Experts on the use of bariatric surgery for the treatment of obesity gathered at the Radcliffe Institute for Advanced Study earlier this month for a two-day seminar examining new evidence that stomach surgery for the treatment of obesity has unexpected side effects, including an increased incidence of alcohol abuse among patients.
Harvard researchers have found that although tailored drugs can eradicate melanoma cells in the lab, they often produce only partial, temporary responses in patients. Researchers have now learned that normal cells that reside within the tumor, part of the tumor microenvironment, may supply factors that help cancer cells grow and survive despite the presence of anti-cancer drugs.
Researchers at Harvard Medical School and Harvard-affiliated Massachusetts General Hospital have found that the body’s immune response to heart attacks actually worsens atherosclerosis, increasing future heart attack risk, according to a study published in the journal Nature.
Rakesh Jain received the 2012 Science of Oncology award from the American Society of Clinical Oncology, recognizing his three decades of pioneering work in the field of oncology.
Researchers at Harvard-affiliated Massachusetts General Hospital have uncovered a new way that animals detect pathogens, by detecting disruptions of critical cellular processes.
A study by researchers at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard is among those chosen to receive Top 10 Clinical Research Achievement Awards from the Clinical Research Foundation.
A new study led by researchers at the Harvard School of Engineering and Applied Sciences and Massachusetts General Hospital has found that normalizing blood vessels within tumors, which improves the delivery of standard chemotherapy drugs, can actually block the delivery of larger nanotherapy molecules.
Harvard stem cell researchers at Massachusetts General Hospital have taken a critical step toward discovering in the relatively near future a drug to control cystic fibrosis, a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
The Cancer Cell Line Encyclopedia is an academic-industry collaboration resource that marries deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments.
A new investigational drug significantly reduced urinary cortisol levels and improved symptoms of Cushing’s disease in the largest clinical study of this endocrine disorder ever conducted.
A study by researchers at Harvard-affiliated Massachusetts General Hospital indicates that the inhaled anesthetic isoflurane impairs learning and memory in mammalian brains by damaging mitochondria, a finding that suggests the anesthetic desflurane may be a better choice for Alzheimer’s patients and others susceptible to cognitive dysfunction.
Harvard researchers find that a subpopulation of the immune cells targeted by HIV may play an important role in controlling viral loads after initial infection, potentially helping to determine how quickly infection will progress.