A study from Brigham and Women’s Hospital offers a new view of how cancer cells extend their reach, co-opting and transforming normal cells through “metastatic hijacking.” The researchers also found that in preclinical models, pharmacological intervention can prevent this from occurring.
The first study to measure the incidence of medication errors and adverse drug events during the perioperative period has found that some sort of mistake or adverse event occurred in every second operation and in 5 percent of observed drug administrations, according to information gathered from 275 operations at Massachusetts General Hospital.
Researchers create complex kidney structures from human stem cells derived from the skin of adult patients.
Specialists in addiction see promise in a more comprehensive approach to treating opioid abuse, aided by medication.
For seminal discoveries that have illuminated the DNA damage response, Stephen J. Elledge, the Gregor Mendel Professor of Genetics and of Medicine at Harvard Medical School and Brigham and Women’s Hospital, is being recognized with the Albert Lasker Basic Medical Research Award. The award is considered to be among the most respected in biomedicine.
Harvard researchers report that by identifying and mimicking important developmental cues, they have been able to drive cells to grow into muscle fibers capable of contracting in a dish and multiplying in large numbers. This new method of producing muscle cells could offer a better model for studying muscle diseases, such as muscular dystrophy, and for testing potential treatments.
A new test can accurately diagnose the Ebola virus disease within minutes at the point of care.
A new study may help explain why glucose tolerance — the ability to regulate blood-sugar levels — is lower at dinner than at breakfast for healthy people and why shift workers are at increased risk of diabetes.
Heart disease is the leading cause of death in women in the United States, deadlier than all forms of cancer combined. The good news is that up to 90 percent of heart disease may be preventable.
A new study by investigators at Dana-Farber Cancer Institute demonstrates that vitamin D can protect some people with colorectal cancer by perking up the immune system’s vigilance against tumor cells.
Harvard researchers at Brigham and Women’s Hospital have uncovered a way to enhance and prolong the therapeutic effects of mesenchymal stem cells in a preclinical model of type 1 diabetes.
The Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine provides support for junior faculty amid life’s crunch time, when demanding research labs, children at home, and other duties all clamor for attention.
With Harvard’s Vivek Murthy confirmed as the next surgeon general, health experts shared their views on areas where his focus and influence are most needed.
A study by Harvard researchers is the first to explore new parents’ attitudes toward genomic testing on newborns. The findings suggest that if such testing becomes available, there would be an interest among new parents, regardless of their demographic background.
Researchers at Harvard-affiliated Brigham and Women’s Hospital have found that greater adherence to the Mediterranean diet was associated with longer telomeres, which serve as a biomarker for aging.
A new genetic test developed by Harvard Medical School physicians at the Dana-Farber/Brigham and Women’s Cancer Center checks cells of leukemia and other blood cancers for 95 genetic mutations, providing a quick genetic profile that physicians can use to make treatment decisions.
The recipient of a bilateral arm transplant and his surgeons appeared at a news conference on Tuesday to thank the donor’s family and to discuss the procedure.
Harvard Stem Cell Institute scientists at Brigham and Women’s Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions.
Research led by Harvard investigators has found six new genes underlying coffee-drinking behavior.
Three nonprofits with strong Harvard ties have joined forces at the front lines of the Ebola epidemic in West Africa.
A study led by Harvard-affiliated researchers is the first to demonstrate that BET bromodomain-containing proteins help execute inflammation in the endothelium while inhibition of BET bromodomain can significantly decrease atherosclerosis in vivo.
Harvard Humanitarian Initiative researchers polled residents of a war-torn part of the Democratic Republic of the Congo, finding that though many think the security situation has improved, trust in government is at a low ebb.
Women who consume higher amounts of caffeine may have a lower risk of developing tinnitus — a steady ringing in the ear — than women who consume less, ...
The protective gear needed to get Sierra Leone’s health clinics reopened, coupled with public education about the Ebola epidemic, are the greatest areas of need, according to a Harvard Fulbright Fellow and physician from Sierra Leone.
Though the threat to the U.S. population from the Ebola outbreak in West Africa is low, the need in epidemic countries is great, says Michael VanRooyen, director of the Harvard Humanitarian Initiative.
In pre-clinical studies conducted by the researchers, a one-time, local injection of the hydrogel-drug combo prevented graft rejection for more than 100 days. This compared with 35.5 days for recipients receiving only tacrolimus, and 11 days for recipients without treatment or only receiving hydrogel.
Harvard-affiliated researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule that acts as a marker for hard-to-find limbal stem cells.
Will Lautzenheiser, a former Boston University film professor who lost his arms and legs from an infection, has been cleared by the Institutional Review Board at the Harvard-affiliated Brigham and Women’s Hospital for a double arm transplant, a complex procedure requiring 12 to 16 hours of work by a team of surgeons.
Harvard Stem Cell Institute scientists collaborating with researchers at the University of Pennsylvania have developed a “genome-editing” approach for permanently reducing cholesterol levels in mice through a single injection, a development with the potential to reduce the risk of heart attacks in humans by 40 to 90 percent.
Fraternal twins Rosh and Roshan Sethi have shared much of their lives, including at Yale as undergraduates and sharing an apartment while enrolled at Harvard Medical School. Now preparing to graduate, they’re anticipating diverging careers, with Roshan exploring radiation oncology and Rosh head and neck surgery.
Will Clerx ’14 studied how going without sleep for long periods affects undergraduates.
Researchers at the Harvard Stem Cell Institute have shown that a protein, one they previously demonstrated can make failing hearts in aging mice appear more like those of young and healthy mice, similarly improves brain and skeletal muscle function in aging mice.
A recent study by a group of Harvard-affiliated researchers found a sharp increase in the use of opioid painkillers among a large group of pregnant women between 2000 and 2007. Its lead author discussed the findings with the Gazette.
Strong Medicine is a Harvard-sponsored archive of stories, photographs, oral histories and other media documenting the medical community’s response to the marathon bombings.
Harvard researchers have estimated that around 1 million children suffer from tuberculosis annually — twice the number previously thought to have the disease and three times the number of cases diagnosed every year.
Harvard researchers have released the first study to show that the adverse effects of fried foods may vary depending on the genetic makeup of the individual.
Harvard stem cell scientists have successfully converted skins cells from patients with early onset Alzheimer’s into the types of neurons affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells.
Hospital stewardship programs, community education, and legal changes to allow pharmaceutical companies to profit longer from new antibiotics are among reforms that experts suggest to fight drug-resistant bacteria.
Researchers have created embryonic stem cells without an embryo. This discovery of a novel reprogramming method of adult cells, without introducing external genetic material, could dramatically shift stem cell research.
The waterproof, light-activated glue developed by researchers at Harvard-affiliated Brigham and Women’s Hospital and Children’s Hospital Boston and their colleagues at MIT can successfully secure biodegradable patches to seal holes in a beating heart.
In the largest study of its kind, people who ate a daily handful of nuts were found to be 20 percent less likely to die from any cause over a 30-year period than those who didn’t consume nuts, say Harvard researchers.
Targeted nanotherapy is the wave of the medical future, according to Omid Farokhzad, a Harvard Medical School and Brigham and Women’s Hospital researcher who has two nanoparticle-based therapies in clinical trials and a slew of ideas for new ways to put the tiny capsules to work for human health.
Harvard research shows that while only 10 percent of adults with sore throat have strep, the only common cause of sore throat requiring antibiotics, the national antibiotic prescribing rate for adults with sore throat has remained at 60 percent.
On Oct. 9, 2012, Taliban gunmen shot 15-year-old Malaa Yousafzai in the head as she rode home from school on a bus. She was simply trying education. On Sept. 27, Yousafzai was in Cambridge to receive the 2013 Peter J. Gomes Humanitarian of the Year Award.
People who are married when diagnosed with cancer live longer than those who are not married. Married patients also tended to have cancers diagnosed at an earlier stage, according to Harvard researchers.
Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.
Benedict Nwachukwu, graduating with a dual M.D./M.B.A. degree, wants to apply the management skills he learned at Harvard Business School to the medical problems he finds in orthopedics and in global health.
MatriTarg Laboratories, a venture created by a team of Harvard fellows seeking new ways to diagnose and treat solid organ fibrosis, claimed the grand prize in the inaugural Deans’ Health and Life Sciences Challenge.
Founding donor Hansjörg Wyss doubled his gift to Harvard’s Wyss Institute for Biologically Inspired Engineering from $125 million to $250 million to the University to further advance the institute’s pioneering work.
Researchers from Harvard-affiliated Brigham and Women’s Hospital (BWH) are the first to report that synthetic silicate nanoplatelets (also known as layered clay) can induce stem cells to become bone cells without the need of additional bone-inducing factors.