Tag: Stuart Schreiber

  • Campus & Community

    Towering figure in organic chemistry

    Yoshito Kishi was a towering figure in organic chemistry renowned for his syntheses of complex natural products.

    3–5 minutes
    Yoshito Kishi.
  • Health

    Strength in love, hope in science

    Husband and wife Eric Minikel and Sonia Vallabh have found a home at the Broad Institute to work toward a treatment for her fatal disease.

    12–18 minutes
  • Health

    Researchers ‘NOTCH’ a victory in war on cancer

    Normal 0 0 1 819 4673 38 9 5738 11.1282 0 0 0 Scientists have devised an innovative way to disarm a key protein considered to be “undruggable,” meaning that all previous efforts to develop a drug against it have failed. Their discovery, published in today’s edition of the journal Nature, lays the foundation for…

    4–6 minutes
  • Science & Tech

    Researchers find new molecule to block ‘Hedgehog’ signaling in cancer, development

    Researchers have achieved a feat drug developers had thought difficult, if not impossible, discovering a compound that blocks the functioning of a key developmental protein by binding to an “undruggable” target — an advance that may provide a new avenue to fight skin, pancreatic, prostate, and other cancers. A team led by Stuart Schreiber, the…

    3–5 minutes
  • Health

    Broad Institute awarded $86 million NIH grant

    Researchers at the Broad Institute of Harvard and MIT have been chosen to receive a six-year, $86M grant from the National Institutes of Health (NIH) to identify and develop molecular tools known as “small molecules,” which can probe the proteins, signaling pathways and cellular processes that are crucial to human health and disease. The Broad…

    3–4 minutes
  • Health

    Novel combination overcomes drug-resistant multiple myeloma cells

    The researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Velcade and an experimental compound that was designed by researchers at the Broad Institute of the Massachusetts Institute of Technology and Harvard University. The report demonstrates that the combination was more than twice as effective as either drug…

    1–2 minutes
  • Health

    Protein packages activate genes

    It’s all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and M.I.T. They did the largest, most detailed study to date of the protein structure that surrounds the human genome. Their findings reveal surprising and previously unknown specifics of how genes get…

    1–2 minutes