Tag: Dana-Farber Cancer Institute
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Nation & World
Breast cancers tied to brain survival
A gene produces a protein that evidently protects cancer cells in the same way it shields brain cells from damage caused by diseases like Alzheimer’s and strokes. “The same substance…
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Nation & World
Death and survival proteins work together
At a cellular level, life-sustaining activities such as glucose metabolism were thought to be carried out by entirely different proteins from those involved in apoptosis, or cell death. “People in…
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Nation & World
Identifying which tumors will spread
Researchers at Harvard Medical School have identified a pattern of gene activity that seems to predict whether cancer will return after it is first treated. The ominous pattern shows up…
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Nation & World
Study sheds light on how the sun causes skin cancer
Scientists have discovered that the sun’s damaging ultraviolet (UV) rays target a series of biochemical signals inside the young skin cell, impairing the cell’s ability to control its proliferation. Lynda…
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Nation & World
Gene signature identifies leukemia patients who should avoid transplants
It was previously known that only slightly over half of the patients with adult T-cell acute lymphoblastic leukemia (ALL) could be cured with chemotherapy. Adult ALL patients often undergo transplants…
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Nation & World
New drug combination may prevent dangerous complication of bone marrow transplantation
An ongoing clinical study by Dana-Farber Cancer Institute scientists suggests that a three-drug therapy, which includes a novel medication called sirolimus, reduces graft-versus-host disease (GVHD) in stem cell transplant patients…
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Nation & World
Scientists discover gene “signature” for tumor’s tendency to spread
Most cancer deaths are caused not by the original or primary tumor but by the metastasizing of tumor cells to other organs. Until now, cancer specialists have viewed the development…
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Nation & World
Study predicts risk of prostate cancer death
Researchers followed 381 people to “identify predictors of time to prostate specific death following external radiation therapy.” “The results of this study give us a better understanding of what form…
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Nation & World
Drinking and hormones, alone and together, increase risk of breast cancer
According to the American Cancer Society, more than 190,000 women are diagnosed with breast cancer annually. It is the second leading cause of cancer deaths in women today. Using data from…
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Nation & World
Researchers isolate key part of cells’ ‘death’ signals
In the cover article of the September 2002 issue of the journal Cancer Cell, researchers from Dana-Farber Cancer Institute reported that peptide subunits of cell-signaling “BH3” proteins could out-maneuver opposing…
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Nation & World
Protein seen to animate cell skeleton
The cytoskeleton is made up of arrays of actin filaments that are arranged into widely different structures — parallel arrays that mediate muscle contraction, networks of branched filaments at the…
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Nation & World
Experimental drug shows promise in treating severe, often-lethal complication of stem cell transplants
An experimental drug called defibrotide reversed severe veno-occlusive disease (VOD) of the liver in more than one third of the stem cell transplant recipients enrolled in a study. VOD is…
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Nation & World
Scientists discover chemical switch that determines muscle fiber type
Published in the Aug. 15, 2002 issue of the journal Nature, findings from a multi-institutional team describe the pivotal role of a molecule called PGC-1 in transforming “fast twitch” fibers…
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Nation & World
Six new breast cancer-susceptibility genes found
The discovery of six new cancer-susceptibility genes grew out of more than 10 years of research by Alan D’Andrea into Fanconi anemia, a condition known to affect only 500 families…
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Nation & World
Sea squirt cancer drug under test
In the United States, researchers at three Harvard University-affiliated hospitals — Massachusetts General Hospital, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital — have been testing a powerful drug on…
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Nation & World
Endostatin shows no toxicity and some clinical activity in latest report on phase I trial
Discovered in the Children’s Hospital Boston laboratory of Judah Folkman, Endostatin is a natural substance that blocks the formation of new blood vessels around and in tumors, thereby disrupting their…
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Nation & World
Genetic computation tells man from microbe
By one estimate (based on bacteria counts in the colon or stool samples), microbes that call our bodies home outnumber human cells 10 to 1. Most of the bacteria, viruses,…
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Nation & World
Physicians vs. the Internet
Each day, about 7.5 million people in the United States use the Internet to get health information, while less than 3 million consult their doctors. Of the 110 million Americans…
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Nation & World
FDA approves Gleevec as oral treatment for gastrointestinal stromal cancer
George Demetri, medical director of the Sarcoma Center at Dana-Farber Cancer Institute and associate professor of medicine at Harvard Medical School, was the lead investigator of a clinical study that…
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Nation & World
Minimally invasive surgical procedure offers limited benefits for colon cancer patients
A national clinical trial compared the effects of standard colon cancer surgery with a newer, minimally invasive procedure for removing tumors called laparoscopic surgery. Researchers from Dana-Farber Cancer Institute and…
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Nation & World
Human genome sequence yields new tool for microbe-hunting
Microbiologists have traditionally identified pathogens (disease-causing organisms) by growing them in a laboratory dish from a sample of infected tissue. But not all pathogens can be cultured this way. Molecular…
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Nation & World
Study upends earlier thinking about immune cell’s readiness against disease
A type of disease-fighting cells in the body — T cells — have a reputation for being ever-ready to fight invading infections. But that’s not the way they really work,…
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Nation & World
Diagnosis by database shows promise
A relatively new approach to researching cancer involves looking at the actions of thousands of genes in cancer tumors. This technique just recently became possible because, using new applications of…
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Nation & World
Scientists using gene chips identify unique form of leukemia
Currently, physicians diagnose and treat a rare form of cancer that strikes infants as a particularly aggressive form of the more common acute lymphoblastic leukemia. The cancer may respond to…
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Nation & World
New study provides mixed report card on informed consent to cancer clinical trials
According to a study that appeared in the Nov. 24, 2001, issue of The Lancet, nearly one quarter of cancer patients who participate in clinical trials do not realize that…
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Nation & World
Immune system discovery may lead to preventive therapy for diabetes
The job of cells known as iNKT cells is to regulate the immune system’s response to infections and other disorders, ensuring that only diseased tissue, not healthy tissue, is targeted…
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Nation & World
Study shows obesity can increase risk of pancreatic cancer
Each year almost 30,000 people in the United States are diagnosed with pancreatic cancer. About the same number of people are killed by it. Pancreatic cancer is the fifth-leading cause…
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Nation & World
Drug hits new molecular target in mice
When doctors diagnose and plan treatment for breast cancers they look for various indicators of how aggressive they are and what treatments will work best. Two-thirds of breast tumors are…
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Nation & World
New drug dissolves stomach tumors
Since July 2000, Harvard and Dana-Farber Cancer Institute researcher George Demetri and his colleagues have treated 148 patients with a rare, lethal stomach cancer known as GIST (Gastrointestinal Stromal Tumor).…