Featured series 
Tag: Cancer
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Health
Identifying which tumors will spread
Researchers at Harvard Medical School have identified a pattern of gene activity that seems to predict whether cancer will return after it is first treated. The ominous pattern shows up in many common types of cancer, including lung, breast, prostate, and brain. What’s more, it may be detectable before the malignancy starts to spread. It’s…
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Imaging technique tracks tumor escape into lymph nodes
For doctors as well as patients, detecting metastases can be a notoriously burdensome affair. Often, the only way to see whether a patient’s lymph nodes are invaded by cancer cells is to surgically remove and inspect them. In some cases, such as gastric cancer, this can mean several hours of sorting through the nodes in…
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Study shows acrylamide in baked and fried foods does not increase risk of certain cancers in humans
Animal and laboratory studies in the past have indicated that acrylamide, a potentially carcinogenic substance, is found in elevated levels in certain foods, such as potato chips, French fries, cereals and biscuits. Acrylamide appears to form as a result of a reaction between specific amino acids and sugars found in foods when heated to high…
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Meat consumption may not increase breast cancer risk
After following 88,647 women for 18 years, the largest and longest individual study of its kind to date, researcher Michelle Holmes and her co-investigators found no evidence that intake of meat during mid-life and later was associated with risk of breast cancer. Similarly, the data showed no reduced risk among women who were vegetarians. In…
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Gene signature identifies leukemia patients who should avoid transplants
It was previously known that only slightly over half of the patients with adult T-cell acute lymphoblastic leukemia (ALL) could be cured with chemotherapy. Adult ALL patients often undergo transplants in an effort to beat back the stubborn disease. Until now there was no way to identify those who have a more favorable outlook and…
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Scientists discover gene “signature” for tumor’s tendency to spread
Most cancer deaths are caused not by the original or primary tumor but by the metastasizing of tumor cells to other organs. Until now, cancer specialists have viewed the development of metastasis as an essentially random and unpredictable event. But that notion is thrown into question with the new finding of a genetic “signature” –-…
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Study predicts risk of prostate cancer death
Researchers followed 381 people to “identify predictors of time to prostate specific death following external radiation therapy.” “The results of this study give us a better understanding of what form of treatment will extend a patient’s life to a point where he’s more likely to die from causes other than prostate cancer,” says Anthony D’Amico,…
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Drinking and hormones, alone and together, increase risk of breast cancer
According to the American Cancer Society, more than 190,000 women are diagnosed with breast cancer annually. It is the second leading cause of cancer deaths in women today. Using data from the Brigham and Women’s Hospital-based Nurses’ Health Study, researchers compared women’s use of postmenopausal hormones and their alcohol intake. That data showed that postmenopausal women…
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Hormone receptor variation linked to cancer risk
Endometrial cancer is the fourth most common cancer in women in this country, according to National Cancer Institute statistics. Progesterone’s important protective role showed up three decades ago, articulated in the unopposed estrogen theory. In the early 1970s, researchers documented that a woman on unopposed estrogen replacement therapy had a 10 times higher chance of…
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Dual signals may drive early breast cancer
Researchers from the lab of Joan Brugge, Harvard Medical School professor of cell biology, may have uncovered one of the central mechanisms of breast cancer. They found that dual signals provided by ErbB2, a cancer-associated gene commonly known as HER2, appear to be required to disrupt the framework of a breast gland during early tumor…
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Protein seen to animate cell skeleton
The cytoskeleton is made up of arrays of actin filaments that are arranged into widely different structures — parallel arrays that mediate muscle contraction, networks of branched filaments at the leading edge of migratory cells, and parallel bundles required to pinch cells apart at the end of cell division. The critical juncture of filament growth…
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Researchers identify protein linked to tumor invasion
Metastasis occurs when cancer cells penetrate the boundaries of the tumor’s tissue and infiltrate the walls of blood vessels or lymph vessels, gaining a means of transport to other parts of the body –- far from the original tumor site –- where they can then grow anew. This process is unique to cancer cells and…
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Six new breast cancer-susceptibility genes found
The discovery of six new cancer-susceptibility genes grew out of more than 10 years of research by Alan D’Andrea into Fanconi anemia, a condition known to affect only 500 families in the United States. Children born with the condition usually develop bone marrow failure early in life, leaving them unable to produce oxygen-carrying red blood…
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Science & Tech
Your community may be harmful to your health
In 1996 the Harvard Center for Cancer Prevention reported that 50 percent of all cancer risk could be eliminated though a modified diet, increased exercise, limited alcohol intake and cessation of tobacco use. However, to achieve such a significant reduction, it is necessary to develop public policies that hinge on our current scientific knowledge of…
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Cell surface proteins can have pro- and anti-angiogenic face
Angiogenesis is the process by which cancer tumors develop a network of blood vessels to feed them, so that they may continue their growth. The strategy that cancer cells use to attract blood vessels to them involves a series of chemical messages. Researchers think of this as a type of cellular kidnapping, luring the blood…
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Minimally invasive surgical procedure offers limited benefits for colon cancer patients
A national clinical trial compared the effects of standard colon cancer surgery with a newer, minimally invasive procedure for removing tumors called laparoscopic surgery. Researchers from Dana-Farber Cancer Institute and the Mayo Clinic and their colleagues found that compared with patients who had the standard operation, those who had the minimally invasive surgery were able…
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Discovery could aid in therapeutic cloning, clamping down on cancer
“Our focus is to understand the very first few steps that drive a cell to become an intestinal cell instead of a muscle cell,” says Yang Shi, Harvard Medical School associate professor of pathology. Shi and his research team, working with worms, recently found a key molecule, CBP-1, that pushes young embryonic cells to become…
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Science & Tech
Diagnosis by database shows promise
A relatively new approach to researching cancer involves looking at the actions of thousands of genes in cancer tumors. This technique just recently became possible because, using new applications of technology, researchers are able to make “diagnoses by database.” At Harvard Medical School, several teams of researchers have recently discovered new types of cancer or…
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Science & Tech
Scientists using gene chips identify unique form of leukemia
Currently, physicians diagnose and treat a rare form of cancer that strikes infants as a particularly aggressive form of the more common acute lymphoblastic leukemia. The cancer may respond to chemotherapy at first, but it tends to recur fatally. That’s why the prognosis is so much worse than for most types of childhood leukemia, which…
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No innocent bystanders
When cancer cells begin to do their destructive work, they have accomplices — normal cells that help nourish the cancerous ones. As Jack Lawler, Harvard Medical School associate professor of pathology at Beth Israel Deaconess, puts it, there are no innocent bystanders in the process. “Previous research focused on the genetics of the cancer cell,”…
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Cell protein potently blocks enzyme linked to cancer
The ends of chromosomes in normal cells eventually unravel, causing the cells to die. This does not happen in cancer cells, however. Cancer cells use an enzyme named telomerase to rebuild the chromosome ends, which are called telomeres, in essence making cancer cells immortal. Since the discovery of the link between telomerase and cancer, scientists…
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Researchers discover new type of cancer
A team led by a Harvard researcher has identified a new type of cancer that primarily affects young girls. Sara Vargas, an instructor in pathology at Harvard Medical School and a researcher in the Department of Pathology at Children’s Hospital in Boston, led the study that identified the new syndrome. The cancer is characterized by…
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Drug hits new molecular target in mice
When doctors diagnose and plan treatment for breast cancers they look for various indicators of how aggressive they are and what treatments will work best. Two-thirds of breast tumors are made up of cells that have receptor molecules for estrogen on their cell surface. The growth of these estrogen-receptor-positive (ER+) tumors depends in part on…
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Study shows obesity can increase risk of pancreatic cancer
Each year almost 30,000 people in the United States are diagnosed with pancreatic cancer. About the same number of people are killed by it. Pancreatic cancer is the fifth-leading cause of cancer-related deaths in the U.S. A study by researchers at Brigham and Women’s Hospital (BWH), the Harvard School of Public Health (HSPH) and Dana-Farber…
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Science & Tech
Preventing cervical cancer in developing nations
Cervical cancer kills approximately 190,000 women each year, most of them in developing nations. It is the third most common cancer world wide. Women who live in more affluent nations have access to Papanicolaou (Pap) tests, which allow pre-cancerous lesions to be detected and treated before they develop into full-blown cancer. But such screening and…
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Cancer cells’ immortality may depend on longevity protein
A team of Harvard Medical School researchers has identified a protein that 10 percent of tumor cells use to attain an immortal state. By blocking the molecule, it may be possible to stop these cancer cells from proliferating. The approach might also be used as part of a two-pronged strategy to combat the remaining 90…
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Increased fruit and vegetable consumption does not reduce risk of breast cancer
A recent Harvard study examined the association between fruit and vegetable consumption and breast cancer. The researchers drew participants from eight separate studies that spanned four countries and involved more than 350,000 women. Women who consumed the highest amount of fruits and vegetables were compared with those who consumed the lowest amount. The analysis revealed…
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Surprise route found for spread of breast cancer
Cancer cells are thought to enter the lymph nodes through the lymphatic system — a multipurpose welter of vessels — but how the cells actually make their way out of a primary tumor and into the lymphatic system has been an enduring puzzle. Massachusetts General Hospital researchers reported recently that they have identified a new…
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Determining colon cancer risk is becoming easier
More than 50 percent of colon cancers can be prevented through lifestyle changes and regular screening tests. The lifestyle changes are the same ones that reduce your risk of heart disease and other cancers. Be more physically active by getting at least three hours a week of physical exercise. Eat less red meat and more…
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Researchers see better treatments for cancer
“Before the development of insulin, diabetes was as deadly as many cancers are today,” says Harvard researcher Joseph Paul Eder, who is testing Endostatin on patients with advanced cancers. “In a couple of decades, people may be able to live 30 to 40 years, or more, after being diagnosed with breast, prostate, or other cancers.”…