Health
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Why bother?
What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.
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Stopping the bleeding
Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’
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Immune-system strategy used to treat cancer may help with Alzheimer’s
Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice
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Is dining with others a sign of happiness?
Shared meals may be a more reliable indicator of well-being than income, Kennedy School researcher says
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Researchers ID genetic disorders that can be treated before birth
Timely detection could reduce morbidity, offer opportunities for early intervention
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How to manage stress during an apocalypse
Psychologist says scrutinizing risk factors, embracing community, adventure are key in age of angst over climate, AI, pandemics
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Fish on ‘the pill’
Human birth control pills are creating problems in the sex lives of fish.
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Newly identified gene variants associated with prostate cancer risk
Three studies presenting newly identified genetic variants that are associated with increased susceptibility to prostate cancer were published recently (Feb. 10) on the advance online site of Nature Genetics. The 10 gene variants double the number of known variants associated with risk of the disease and are the result of genomewide association studies.
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Anxiety linked to overestimation of breast cancer risks
Elevated levels of anxiety may cause women with ductal carcinoma in situ (DCIS), the most common form of noninvasive breast cancer, to overestimate their risk of recurrence or dying from breast cancer, suggests a study led by researchers at Harvard-affiliated Dana-Farber Cancer Institute in Boston.
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Infants are able to recognize quantity
By looking at infant brain activity, researchers have found that babies as young as 3 months old are sensitive to differences in numerical quantity. Additionally, the scientists were able to see that babies process information about objects and numbers in different, dissociated parts of the brain, which is also the case in older children and in adults.
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Web technology allows health experts from around globe to kibitz
It was close to midnight one day this week in Durban, South Africa, when Harvard AIDS researcher Bruce D. Walker switched on his computer and made a visit to 104 Mt. Auburn St. in Cambridge.
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BWH-led tuberculosis research project receives $14M NIH grant
Researchers at Brigham and Women’s Hospital (BWH), the Harvard School of Public Health (HSPH), Harvard Medical School (HMS) and Partners In Health (PIH) have received a grant of $14 million over five years from the National Institutes of Health to study multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). The goal of the project is to better understand the development and transmission of drug-resistant tuberculosis and to identify practical approaches to reduce the public health burden created by this disease.
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Making statistics not just palatable, but delicious
Money, love, health, innocence or guilt — even finding the right wine. Who doesn’t want to know more? “Real-Life Statistics: Your Chance for Happiness (or Misery),” offered this semester by Harvard’s Department of Statistics, will explore the critical tools to make good judgments in matters large and small.
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How brain cells make good connections
Harvard neuroscientist Venkatesh N. Murthy has a sunny second-floor office on Divinity Avenue, where he is a professor in Harvard’s Department of Molecular and Cellular Biology. In one corner is a set of weights and a soccer ball — both untouched in over a year, he said, because of an intensely busy schedule.
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Ethicists, philosophers discuss selling of human organs
In nearly every country in the world, there is a shortage of kidneys for transplantation. In the United States, around 73,000 people are on waiting lists to receive a kidney. Yet 4,000 die every year before the lifesaving organ is available.
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Major step forward in understanding cell reprogramming
Harvard Stem Cell Institute (HSCI) and Massachusetts General Hospital (MGH) researchers have taken a major step toward eventually being able to reprogram adult cells to an embryonic stem cell-like state…
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Cancer stem cells can be targeted for destruction
It’s increasingly believed among scientists that nearly every cancer contains small populations of highly dangerous cells — cancer stem cells — that can initiate a cancer, drive its progression, and create endless copies of themselves. On the theory that targeting these cells might be an effective therapeutic strategy, researchers around the world have begun isolating stem cells from various kinds of cancers. Now, for the first time, researchers at Children’s Hospital Boston and Brigham and Women’s Hospital (BWH) have found a strategy that selectively targets cancer stem cells for destruction, successfully halting one of the deadliest cancers — melanoma — in mice.
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Research in brief
Major differences in protocols used to determine brain death; Harvard researchers achieve stem cell milestone; Consortium links chromosome abnormality to autism disorders; Blocking HIV infection; Oral osteoporosis meds appear to reduce the risk of jaw degradation; Six new genetic variants linked to heart-disease risk factor; Gene variation may elevate risk of liver tumor in some patients; Cancer stem cells can be targeted for destruction
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Drug helps certain brain tumor patients live longer
People who receive high doses of the chemotherapy drug methotrexate to treat a certain type of brain tumor appear to live longer than people receiving other treatments, according to research published in the Jan. 29 issue of Neurology, the medical journal of the American Academy of Neurology.
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Chimpanzees have ‘top guns’ on hunts
While hunting among chimpanzees is a group effort, key males known as “impact hunters” are highly influential within the group. They are more likely to initiate a hunt, and hunts rarely occur in their absence, according to a new study. The findings, which appear in the current issue of Animal Behaviour, shed light on how and why some animals cooperate to hunt for food, and how individual variation among chimpanzees contributes to collective predation.
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Suicide risk factors consistent globally
Risk factors for suicidal thoughts, plans, and attempts are consistent across countries, and include having a mental disorder and being female, younger, less educated, and unmarried. So says new research from Harvard University and World Health Organization (WHO) World Mental Health Survey Initiative. The study examined both the prevalence and the risk factors for suicide across 17 countries, and is the largest, most representative examination of suicidal behavior ever conducted.
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‘Where do I come from?’
Harvard graduates often return to the University to let their professors know what they’ve been up to since they finished their degree.
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Drug based on MGH discovery may significantly improve treatment of dangerous blood disorder
Two clinical trials of the novel drug romiplostim (Nplate) show that it significantly improved platelet levels in patients with chronic immune thrombocytopenic purpura (ITP), a hematologic disorder that can cause uncontrolled…
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Grapefruit compound may help combat hepatitis C infection
A compound that naturally occurs in grapefruit and other citrus fruits may be able to block the secretion of hepatitis C virus (HCV) from infected cells, a process required to…
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Stem cell lines created from discarded IVF embryos
Human embryos that are discarded every day as medical waste from in vitro fertilization (IVF) clinics could be an important source of stem cells for research, according to a team…
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Cancer drug activates adult stem cells
The use of a drug used in cancer treatment activates stem cells that differentiate into bone appears to cause regeneration of bone tissue and be may be a potential treatment…
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HOPE in African HIV/AIDS fight
It was close to midnight one day this week in Durban, South Africa, when Harvard AIDS researcher Bruce D. Walker switched on his computer and made a visit to 104…
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Harvard researchers receive $14 million TB study grant
Harvard researchers at Brigham and Women’s Hospital (BWH), Harvard School of Public Health (HSPH), Harvard Medical School (HMS) and Partners In Health (PIH) have received a grant of $14 million…
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Dramatic increase in ER waiting time for seriously ill patients
Patients of all racial, ethnic, and socioeconomic status are facing ever-increasing waits for care in emergency rooms, according to a study published online today by the journal Health Affairs. The…
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M. Judah Folkman, biomedical pioneer, dies at 74
One of Harvard Medical School’s (HMS) most forward-looking and innovative physician-scientists, M. Judah Folkman, died suddenly Monday (Jan. 14) after suffering a heart attack at the Denver International Airport in…
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Peter Black named President-Elect of World Federation of Neurosurgical Societies
Peter Black, MD, PhD, Franc D. Ingraham Professor of Neurosurgery at Harvard Medical School and founding chair of the Brigham and Women’s Hospital Department of Neurosurgery has been elected President-Elect…
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Chromosomal abnormality linked to autism disorders
Researchers have fitted another piece into the complex genetic puzzle that is autism, finding DNA deletions and duplications on a specific chromosome that they say explains one to two percent…
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Those least needy most likely to get free drug samples
Most free drug samples are not used to ease the burden of the poor or the uninsured, but rather go to those most able to pay for their prescriptions, according…
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Gene variation may elevate risk of liver tumor in patients with cirrhosis
A genetic variation appears to significantly increase the risk that individuals with cirrhosis of the liver will develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause…
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Harvard researchers achieve stem cell milestone
Harvard Stem Cell Institute researchers have successfully turned back the clock on human skin cells, causing them to revert to an embryonic stem cell-like state from which they can become…
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Microchip-based device can detect rare tumor cells in bloodstream
A team of investigators from the Massachusetts General Hospital (MGH) BioMicroElectroMechanical Systems (BioMEMS) Resource Center and the MGH Cancer Center has developed a microchip-based device that can isolate, enumerate and…