Health
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Bile imbalance linked to liver cancer
Key molecular switch identified, sheds new light on treatment interventions
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FDA-approved smoking cessation pill helps break vaping habit
Clinical trial shows teens and young adults had three times more success quitting than their placebo counterparts
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U.S. pregnancy-related deaths continuing to rise
Study researcher says nation, which leads high-income peers in maternal mortality, needs better prenatal, extended postpartum care
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Rewriting genetic destiny
David Liu, Breakthrough Prize recipient, retraces path to an ‘incredibly exciting’ disease fighter: ‘This is the essence of basic science.’
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Why bother?
What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.
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Stopping the bleeding
Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’
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A potential new anthrax therapy
A vaccine to protect humans against anthrax already exists, but since infection is rare, a widespread vaccination program is not practical. To be effective against anthrax, antibiotics must be given…
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Caffeine linked to protection from Parkinson’s disease
Parkinson’s disease is a progressive nervous disease occurring generally after age 50. It destroys brain cells that produce dopamine and is characterized by muscular tremor, slowing of movement, weakness and…
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Medicare rules restrict good care for dying patients
Many health care providers believe that Medicare regulations block them from providing good care to dying patients. Researchers from Harvard Medical School, the Harvard School of Public Health, and RAND…
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Nurse staffing levels directly impact patient health and survival
Researchers who looked at hospital discharge data for more than 5 million patients found consistent relationships between nurse staffing levels and five adverse patient outcomes: urinary tract infections, pneumonia, shock,…
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Women’s menstrual cycle holds clue to cocaine response
During the first half of their menstrual cycles, when their estrogen levels are high, women are protected from the brain-damaging effects of cocaine use, according to a research study conducted…
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Circadian rhythms may distinguish Alzheimer’s disease
Researcher David Harper and his colleagues monitored two key components of the circadian system — the rise and fall of core body temperature and the waxing and waning of spontaneous…
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First domino falls in research on sense of touch
Unlike the other four senses, touch is ubiquitous, involving sensory terminals dispersed over the outside and on the inside of the body. This system encodes a variety of sensations in…
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Scientists look people in the ‘I’
Harvard researchers seek a scientific answer to a question posed by 16th century philosopher René Descartes: “What is this ‘I’ that I know?” “Understanding the brain essence of self-awareness helps…
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Pain promoter plays unexpected role in central nervous system
Despite all the attention it draws in patients, pain has only in recent years been deemed a subject worthy of scientific scrutiny.
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Accomplice fingered in cholera toxicity
A study published in March 2001 revealed one of the ways that cholera toxin hijacks some of the cell’s own machinery. In uncovering part of the toxin’s trail, a team…
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Non-smoking bar and restaurant workers inhale as much as active smokers
Working in a bar or restaurant can expose you to as much tobacco smoke as if you were an active smoker, a researcher based at the Harvard School of Public…
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Strict enforcement of lead-exposure-prevention policies shows clear benefits
Even at low levels, lead poisoning in children can cause IQ deficiencies, reading and learning disabilities, impaired hearing, reduced attention spans, hyperactivity and other behavior problems. Children who live in…
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Cancer cells’ immortality may depend on longevity protein
A team of Harvard Medical School researchers has identified a protein that 10 percent of tumor cells use to attain an immortal state. By blocking the molecule, it may be…
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Human genome tally: Is recount in order?
The surprising finding that humans have fewer genes than expected led to endless speculations and editorial comments. Would biotech stocks be threatened? Should humans be more humble? Were entirely new…
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Nonsmoking college students 40 percent less likely to take up smoking when they live in smoke-free dorms
Although 81 percent of colleges prohibit smoking in all public areas, only 27 percent prohibit smoking in students’ dormitories. Harvard School of Public Health researchers say the finding sends a…
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Rules for music wired into the brain
“Music is in our genes,” says Mark Jude Tramo, a musician, prolific songwriter, and neuroscientist at Harvard Medical School. “Many researchers like myself are trying to understand melody, harmony, rhythm,…
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Testing to identify drug-resistant AIDS strains is cost-effective
A new study led by the Harvard Center for Risk Analysis, published in the Annals of Internal Medicine in March 2001, finds that testing people with HIV to determine whether…
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Surgery without scalpels
Paul Simmons, a 29-year-old Maine farmer, suffered from a lung tumor. In February 2001, at Harvard-affiliated Brigham and Women’s Hospital in Boston, a probe containing a long needle was inserted…
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Medicare patients give higher overall marks to nonprofit health plans
The first large-scale national study that examines the relationship between health plan characteristics and patient ratings of their plan found that Medicare patients prefer not-for-profit or local plans over for-profit…
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Majority of Alzheimer’s plaques cleared from brains of living mice
Harvard Medical School researchers, working with scientists at Elan Pharmaceuticals, cleared 70 percent of Alzheimer’s plaques from the brains of mice by applying anti-plaque antibodies directly to the mouse brains…
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Brain hesitates in assembling mosaic of motion
Your brain must integrate information from many different neurons in the primary visual cortex to interpret movement. But how does this complicated process work? Richard Born and Christopher Pack of…
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Lyme disease vaccine found cost-effective only for those at high risk
Lyme disease, a bacterial infection transmitted through deer tick bites, is rapidly emerging in the U.S. and currently affects about 15,000 people each year. But incidence varies widely according to…
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Simulating disease trends with massive mathematical models
Researcher Karen Kuntz is currently developing a model to evaluate trends in colorectal cancer incidence and mortality. Nearly 50,000 Americans die each year from the disease, despite the fact that…
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How embryonic stem cells become fine-tuned brains
Research by Michael Greenberg, Harvard Medical School professor of neurology at Children’s Hospital, begins to explain how the embryonic brain’s stem cells decide whether to mature into nerve or glial…
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Gene initiates joint formation
Researchers at Harvard Medical School have identified a molecule that plays a central role in the initiation of joint formation. Studying limb formation in the developing chick, postdoctoral fellow Christine…
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In human genome race, competition spurred better science
The conflicts between the two teams — one publicly funded, one private — that raced to sequence the human genome often drew more attention than the actual completion of the…
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New vaccines could balance global burden of disease
The scientific community believes that diseases that have long plagued the world can be controlled by vaccination. But vaccines won’t work unless they reach the people who need them most…
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Growth factor seen to reverse loss of muscle from aging, disease
Previous work by Nadia Rosenthal of Harvard Medical School and her colleagues showed that injection of a virus directing the expression of a molecule known as insulin-like growth factor I…
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T-cell response to HIV proteins may make them vaccine candidates
Development of a vaccine against HIV-1 has long focused on the virus’s structural proteins. These molecules are expressed relatively late in the viral life cycle, after HIV-1 has decreased the…
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Specific gene provides health benefits for moderate drinkers
Moderate alcohol consumption among people who have a specific version of a gene that metabolizes alcohol yields health benefits — less risk of heart disease and higher good cholesterol levels.…