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Tag: Massachusetts General Hospital
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Campus & Community
Nobel Prize in Medicine shared by Harvard Medical School professor
Jack W. Szostak, a professor of genetics at Harvard Medical School, is one of three winners of the Nobel Prize in Physiology or Medicine this year, with Elizabeth Blackburn of the University of California, San Francisco, and Carol W. Greider of Johns Hopkins University School of Medicine….
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Campus & Community
Telomerase work wins Szostak Nobel Prize in medicine
Jack W. Szostak, a genetics professor at Harvard Medical School and Harvard-affiliated Massachusetts General Hospital (MGH), has won the 2009 Nobel Prize in physiology or medicine for work on cellular structures called telomeres, which protect chromosomes from degradation.
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Health
Low-carb diets linked to atherosclerosis and impaired blood vessel growth
Even as low-carbohydrate/high-protein diets have proven successful at helping individuals rapidly lose weight, little is known about the diets’ long-term effects on vascular health. Now, a study led by team of Harvard researchers at Beth Israel Deaconess Medical Center (BIDMC) provides some of the first data on this subject, demonstrating that mice placed on a…
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Health
Study finds promise in combined transplant/vaccine therapy for high-risk leukemia
Two of the most powerful approaches to cancer treatment — a stem cell transplant and an immune system-stimulating vaccine — appear to reinforce each other in patients with an aggressive, hard-to-control form of leukemia, Harvard scientists at Dana-Farber Cancer Institute (DFCI) have found. The researchers report that patients with high-risk acute myeloid leukemia (AML) or…
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Health
NIH renews Harvard Center for AIDS Research grant for another five years
The National Institutes of Health has renewed for five years – and $18.1 million – the funding for the Harvard University Center for AIDS Research (Harvard CFAR). Harvard is one of only 20 NIH CFAR sites in the U.S. and first received the designation in 2004. The award, under the umbrella of the Harvard Initiative…
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Health
Postdiagnosis aspirin use reduces risk of dying from colorectal cancer
Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death, report Harvard researchers at Massachusetts General Hospital (MGH), Dana-Farber Cancer Institute (DFCI) and Brigham and Women’s Hospital. In today’s edition of the Journal of the American Medical Association, the study’s authors also find that the aspirin-associated survival advantage was seen…
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Health
New steps forward in cell reprogramming
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital (MGH) have substantially improved the odds of successfully reprogramming differentiated cells into induced pluripotent stem cells (iPS) by blocking the activity of the gene that instructs the cells to stop dividing. Konrad Hochedlinger and colleagues at the MGH Center for Regenerative Medicine also found that…
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Health
MGH researchers develop potentially safer general anesthetic
News release — Mass. General team develops potentially safer general anesthetic A team of Harvard Medical School (HMS) researchers at Massachusetts General Hospital (MGH) has developed a new general anesthetic that may be safer for critically ill patients. In the August issue of Anesthesiology, they describe preclinical studies of the drug called MOC-etomidate – a…
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Health
Earlier AIDS drug treatment would save 76,000 lives over 5 years
EMBARGO DATE CORRECTION — JULY not August — Study suggests earlier HIV antiviral treatment saves lives and is cost effective, even in areas of limited resources Early initiation of lifesaving antiretroviral therapies should be the standard of care for all HIV-infected patients, even those in countries with limited medical and financial resources, according to a…
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Health
Damon Runyon Cancer Research Foundation awards fellowships to Harvard scientists
The Damon Runyon Cancer Research Foundation, a nonprofit organization focused on supporting exceptional early career researchers and innovative cancer research, has selected four Harvard affiliates to receive Damon Runyon fellowships at its May 2009 Fellowship Award Committee review.
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Health
Human cardiac master stem cells identified
Harvard Stem Cell Institute researchers at Massachusetts General Hospital have identified the earliest master human heart stem cell from human embryonic stem cells – ISL1+ progenitors – that give rise to a family of cells that form the essential portions of the human heart. The discovery, by a group led by Kenneth Chien, director of…
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Health
Common ECG finding may indicate serious cardiac problems
A common electrocardiogram (ECG) finding that has largely been considered insignificant may actually signal an increased risk of atrial fibrillation (a chronic heart rhythm disturbance), the future need for a permanent pacemaker, and an increased risk for premature death. In their report in the June 24 Journal of the American Medical Association (JAMA), researchers from…
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Health
Researchers learn how mutations extend life span
In the sense that organisms existing today are connected through a chain of life – through their parents, grandparents, and other ancestors – almost a billion years back to the first animals of the pre-Cambrian era, an animal’s reproductive cells can be considered to be immortal. These germline cells generate their offspring’s somatic cells –…
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Health
Video can help patients make end-of-life decisions
Viewing a video showing a patient with advanced dementia interacting with family and caregivers may help elderly patients plan for end-of-life care, according to a study led by Massachusetts General Hospital (MGH) researchers. See the advanced dementia video More videos from the same researcher In their report in the journal BMJ, the investigators found that…
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Health
Genetic testing for breast or ovarian cancer risk may be greatly underutilized
Although a test for gene mutations known to significantly increase the risk of hereditary breast or ovarian cancer has been available for more than a decade, a new study finds that few women with family histories of these cancers are even discussing genetic testing with their physicians or other health-care providers. In an online report…
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Health
Electronic system may reduce adverse drug events
Researchers at Brigham and Women’s and Massachusetts General hospitals report that using a computerized application to record and track patients’ medications could decrease the occurrence of potentially harmful medication discrepancies. These findings appear in the April 27 issue of Archives of Internal Medicine. The term “medication discrepancies” describes the unexplained differences in medication regimens that…
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Health
Simple bedside test improves diagnosis of chronic back pain
A simple and inexpensive method of assessing pain, developed by Harvard researchers at Massachusetts General Hospital (MGH), is better than currently used techniques for distinguishing neuropathic pain – pain caused by damage to the nervous system — from other types of chronic back pain. Being able to more precisely determine the underlying nature of the…
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Health
Lighting up Parkinson’s disease research
Most people do not think of jellyfish at the mention of Parkinson’s disease research. But, at the MassGeneral Institute for Neurodegenerative Disease (MIND), researchers Pamela McLean and Bradley Hyman are using the same fluorescent protein that causes the green glow of jellyfish for their experiments testing potential drugs for the treatment of Parkinson’s disease (PD).…
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Health
Modification of mutant Huntington’s protein increases its clearance from brain cells
A new study has identified a potential strategy for removing the abnormal protein that causes Huntington’s disease (HD) from brain cells, which could slow the progression of the devastating neurological disorder. In today’s edition of the journal Cell, a team of Harvard researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) describes how an alteration…
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Health
Angiogenesis inhibitor improves brain tumor survival by reducing swelling
The beneficial effects of anti-angiogenesis drugs in the treatment of the deadly brain tumors called glioblastomas appear to result primarily from reduction of edema – the swelling of brain tissue – and not from any direct anti-tumor effect, according to a study from Harvard researchers at Massachusetts General Hospital (MGH). Their report, to be published…
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Science & Tech
Five at Harvard named HHMI Early Career Scientists;
Five Harvard scientists are among 50 young scientists nationwide who will have their work supported for the next six years by a new initiative from the Howard Hughes Medical Institute (HHMI). HHMI today announced that the selected scientists are at 33 institutions across the United States and have led their own laboratories for two to…
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Health
U.S. hospitals slow to adopt electronic health records, citing cost
There is broad consensus that electronic health records (EHR) have the potential to improve the efficiency and effectiveness of health care providers. Yet, to date, there has been no reliable estimate of the prevalence of EHR use among U.S. hospitals. In a new study, researchers from the Harvard School of Public Health (HSPH), Massachusetts General…
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Science & Tech
Policies regarding IRB members’ industry contacts often lacking
At a time of heightened concern about conflicts of interest posed by relationships between academic medical researchers and commercial firms, a new study finds that a significant number of academic institutions do not have clear policies covering the industrial relationships of members of institutional review boards (IRBs), committees charged with ensuring that clinical studies uphold…
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Health
Mechanism directing stem cells to their destination identified;
Harvard Stem Cell Institute (HSCI) researchers have for the first time identified in mice a cellular mechanism that directs stem cells to their ultimate destination in the body. The finding in blood stem cells by HSCI co-director David Scadden and colleagues holds the promise of greatly increasing the efficiency of the bone marrow transplants used…
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Health
Blumenthal named national coordinator for health information technology
The U.S. Department of Health and Human Services (HHS) announced today (March 20) the selection of David Blumenthal as the Obama administration’s choice for national coordinator for health information technology. A physician at Massachusetts General Hospital (MGH), Blumenthal is also director of the MGH Institute for Health Policy and Samuel O. Thier Professor of Medicine…
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Health
Study identifies human genes required for hepatitis C viral replication
Massachusetts General Hospital (MGH) researchers are investigating a new way to block reproduction of the hepatitis C virus (HCV) — targeting not the virus itself but the human genes the virus exploits in its life cycle. In the March 19 Cell Host & Microbe, they report finding nearly 100 genes that support the replication of…
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Health
Blood type study sheds light on biology of pancreatic cancer
Offering a novel clue about the basic biology of pancreatic cancer, researchers at Dana-Farber Cancer Institute have confirmed a decades-old discovery of a link between blood type and the risk of developing the disease. The finding, published online by the Journal of the National Cancer Institute on March 10, is based on an analysis of…
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Health
Taking a stride toward synthetic life
Harvard scientists have cleared a key hurdle in the creation of synthetic life, assembling a cell’s critical protein-making machinery in an advance with both practical, industrial applications and that advances the basic understanding of life’s workings. George Church, a genetics professor at Harvard Medical School and member of Harvard’s Origins of Life Initiative, reported the…
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Health
New ALS gene identified
A collaborative research effort spanning nearly a decade between Harvard researchers at Massachusetts General Hospital (MGH) and King’s College London (KCL) has identified a novel gene for inherited amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease). This is the fourth gene associated with familial forms of the devastating neurological disorder. Two papers, published…
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Health
Alzheimer’s-associated plaques may have impact throughout the brain
The impact of the amyloid plaques that appear in the brains of patients with Alzheimer’s disease may extend beyond the deposits’ effects on neurons — the cells that transmit electrochemical signals throughout the nervous system. In an article in the Feb. 27 issue of Science, Harvard researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND)…