Featured series 
Tag: Genetics
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Science & Tech
Scientists create custom three-dimensional structures with ‘DNA origami’
By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of…
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Health
Broad scientists to sequence multiple myeloma samples
The Multiple Myeloma Research Foundation (MMRF) announced today a collaboration with the Broad Institute of Harvard and MIT to systematically uncover the molecular changes underlying multiple myeloma by whole-genome sequencing…
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Health
Study finds genetic links to age of first menstrual period, menopause
Newly identified gene variants associated with the age at which females experience their first menstrual period and the onset of menopause may help shed light on the prevention of breast and endometrial cancer, osteoporosis, and cardiovascular disease.
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Health
MicroRNA discovered to play role in DNA repair
Among their many roles as message couriers and gene regulators, microRNA molecules also help control the repair of damaged DNA within cells, Dana-Farber Cancer Institute and Harvard Medical School scientists…
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Health
For cancer cells, genetics alone is poor indicator for drug response
In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups…
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Health
Newly identified genetic variants found to increase breast cancer risk
A large-scale effort to identify genetic markers of breast cancer has uncovered two common genetic variants that increase risk of the disease in women of European ancestry. The paper, published…
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Health
Study identifies human genes required for hepatitis C viral replication
Massachusetts General Hospital (MGH) researchers are investigating a new way to block reproduction of the hepatitis C virus (HCV) — targeting not the virus itself but the human genes the…
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Health
Taking a stride toward synthetic life
Harvard scientists have cleared a key hurdle in the creation of synthetic life, assembling a cell’s critical protein-making machinery in an advance with both practical, industrial applications and that advances…
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Health
Predicting risk of stroke from one’s genetic blueprint
A new statistical model could be used to predict an individual’s lifetime risk of stroke, according to the results of a study by Harvard researchers at the Children’s Hospital Boston Informatics Program.
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Health
Common gene variants increase risk of hypertension
A new study has identified the first common gene variants associated with an increased incidence of hypertension — a significant risk factor for heart attack, stroke, and kidney failure. The…
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Health
Neural wiring hints at nervous system gene limits
Genetics may play a surprisingly small role in determining the precise wiring of the mammalian nervous system, according to painstaking mapping of every neuron projecting to a small muscle mice use to move their ears. These first-ever mammalian “connectomes,” or complete neural circuit diagrams, reveal that neural wiring can vary widely even in paired tissues…
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Health
International study identifies gene variants associated with early heart attack
The largest study ever completed of genetic factors associated with heart attacks has identified nine genetic regions — three not previously described — that appear to increase the risk for early-onset myocardial infarction. The report from the Myocardial Infarction Genetics Consortium, based on information from a total of 26,000 individuals in 10 countries, was given…
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Health
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
Researchers have reported the first clinical evidence that gene therapy reduces symptoms in patients with rheumatoid arthritis (RA), an important milestone for this promising treatment . Described in the February issue of the journal Human Gene Therapy, the findings stem from a study of two patients with severe rheumatoid arthritis conducted in Germany and led…
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Health
Scientists uncover new class of mammalian genes with key functions
A research team at the Broad Institute of Harvard and MIT and Beth Israel Deaconess Medical Center has uncovered a vast new class of previously unrecognized mammalian genes that do…
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Health
New obesity-related genes identified
A large international consortium has made significant inroads into uncovering the genetic basis of obesity, adding six new genetic variants to the two already linked to higher body mass index (BMI) in previous studies. Most of the newly discovered genes had never before been suspected of having a role in body weight and, curiously, many…
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Health
Research may lead to treatment for retinitis pigmentosa
Rods and cones coexist peacefully in healthy retinas. Both types of cells occupy the same layer of tissue and send signals when they detect light, which is the first step in vision.
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Science & Tech
Of Neanderthals and dairy farmers
Harvard Archaeology Professor Noreen Tuross sought to rehabilitate the image of Neanderthals as meat-eating brutes last week, presenting evidence that, though they almost certainly ate red meat, Neanderthal diets also consisted of other foods — like escargot.
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Health
Connie Cepko
In some ways, Connie Cepko’s job has gotten easier. The Harvard Medical School genetics professor is working to uncover the mysteries of the eye, to understand how it develops and…
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Health
Genetic screening no better than traditional risk factors for predicting type 2 diabetes
Screening for a panel of gene variants associated with the risk for type 2 diabetes can identify adults at risk for the disorder but is not significantly better than assessment based on traditional risk factors such as weight, blood pressure, and blood sugar levels.
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Health
For innovative undergrads, bacteria make some buzz
A team of undergraduates who engineered a bacterial biosensor with electrical output recently made some buzz at the 2008 international Genetically Engineered Machine (iGEM) competition held at the Massachusetts Institute of Technology (MIT).
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Health
A single gene leads yeast cells to cooperate against threats
An ingenious social behavior that mobilizes yeast cells to cooperate in protecting each other from stress, antibiotics, and other dangers is driven by the activity of a single gene, scientists report this week in the journal Cell. The cooperating cells use the same gene, dubbed FLO1, as a marker for detecting “cheaters,” cells that try…
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Campus & Community
Gary Ruvkun took a roundabout route to science
Gary Ruvkun has made a career out of imagining the unimaginable, and of surrounding himself with like-minded thinkers who let the wheels of thought spin until they catch on something hard, gain traction, and take off.
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Health
Gene scan of Alzheimer’s families identifies four new suspect genes
The first family-based genome-wide association study in Alzheimer’s disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the…
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Health
Gene therapy restores vision to mice with retinal degeneration
Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings of the National Academy of Sciences, describes the effects of broadly expressing a light-sensitive protein in other…
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Health
Genome Project releases data on 10 genetic pioneers
The world moved a step deeper into the DNA age Monday (Oct. 20) as 10 volunteers released their genetic and medical information on the Internet as part of a multiyear effort to make genetic data an everyday part of medical care.
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Health
Researchers identify promising gene target for neuroblastoma therapy
Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths.
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Health
Volunteers unveil DNA, medical data in push for everyday gene sequencing
The world moved a step deeper into the DNA age yesterday as 10 volunteers released their genetic and medical information on the Internet as part of a multi-year effort to…
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Health
Major step forward in cell reprogramming
Imagine, if you can, a day within the next decade when a physician-scientist could remove a skin cell from your arm and with a few chemicals turn that fully formed adult cell into a dish of stem cells genetically matched to you.
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Health
Genetic ‘fingerprint’ shown to predict liver cancer’s return
Scientists have reached a critical milestone in the study of liver cancer that lays the groundwork for predicting the illness’s path, whether toward cure or recurrence. By analyzing the tissue in and around liver tumors, an international research team has identified a kind of genetic “fingerprint” that can help predict whether cancers will return.