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  • Broad Institute awarded $86 million NIH grant

    Researchers at the Broad Institute of Harvard and MIT have been chosen to receive a six-year, $86M grant from the National Institutes of Health (NIH) to identify and develop molecular…

  • Samuel Kou appointed professor of statistics

    Samuel Kou, whose modeling of nanoscale processes within molecules has opened up important new frontiers at the intersection of statistics and chemistry, has been appointed professor of statistics in Harvard…

  • Harvard Stem Cell Institute researchers turn one form of adult mouse cell directly into another

    In  a feat of biological prestidigitation likely to turn the field of regenerative medicine on its head, Harvard Stem Cell Institute (HSCI) co-director Doug Melton and post doctoral fellow Qiao…

  • Driven:

    When the baby vomited again, Gail Melton knew something was seriously wrong with her second child, a son she and her husband, Doug Melton, had named Sam. She phoned Doug…

  • Jamaican lizards mark their territory with shows of strength at dusk and dawn

    What does ageless fitness guru Jack LaLanne have in common with a Jamaican lizard? Like LaLanne, the lizards greet each day with vigorous push-ups. That’s according to a new study…

  • Next-generation tool for visualizing genomic data introduced

    Researchers are collecting vast amounts of diverse genomic data with ever-increasing speed, but effective ways to visualize these data in an integrated manner have lagged behind the ability to generate them. To address this growing need, researchers at the Broad Institute of MIT and Harvard have developed the Integrative Genomics Viewer (IGV), a novel and freely available visualization tool that helps users simultaneously integrate and analyze different types of genomic data, and gives them the flexibility to zoom in on a specific genomic region of interest or to pan out for a broad, whole-genome view.

  • Neurons created from skin cells of elderly patients with ALS

    Less than 27 months after announcing that he had institutional permission to attempt the creation of patient- and disease-specific stem cell lines, Harvard Stem Cell Institute (HSCI) principal faculty member Kevin Eggan proclaimed the effort a success — though politically imposed restrictions and scientific advances prompted him to use a different technique than originally planned.

  • Daley and colleagues create 20 disease-specific stem cell lines

    Harvard Stem Cell Institute (HSCI) researcher George Q. Daley, associate director of the Stem Cell Program at Children’s Hospital Boston, has with HSCI colleagues Chad Cowan and Konrad Hochedlinger of Massachusetts General Hospital (MGH) produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem cell (iPS) technique. The work is described in a paper published in the Aug. 7 online edition of the journal Cell.

  • Daley and colleagues create 20 disease-specific stem cell lines

    Harvard Stem Cell Institute (HSCI) researcher George Q. Daley, associate director of the Stem Cell Program at Children’s Hospital Boston, has with HSCI colleagues Chad Cowan and Konrad Hochedlinger of Massachusetts General Hospital (MGH) produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem cell (iPS) technique. The work is described in a paper published in the Aug. 7 online edition of the journal Cell.

  • Joint Harvard-Brazil program fights entrenched diseases

    Recently (Jan. 6-21), 15 Harvard and 16 Brazilian students participated in an intensive experience: the first Harvard-Brazil Collaborative Course on Infectious Diseases. The course, which was offered by the Harvard School of Public Health (HSPH) and the Santa Casa de Misericórdia de São Paulo Medical School (FCMSCSP) with the support of the Harvard University Brazil Studies Program at the David Rockefeller Center for Latin American Studies (DRCLAS), included lectures and informal discussions and visits to clinics, hospitals, laboratories, and community programs.

  • Potential diabetes treatment selectively kills autoimmune cells from human patients; study confirms feasibility of human trials

    In experiments using blood cells from human patients with diabetes and other autoimmune disorders, Massachusetts General Hospital (MGH) researchers have confirmed the mechanism behind a potential new therapy for type…

  • Joslin study identifies protein that produces ‘good’ fat; finding may lead to ways to treat, prevent obesity

    A study by researchers at the Joslin Diabetes Center has shown that a protein known for its role in inducing bone growth can also help promote the development of brown…

  • Bone marrow stem cells may help control inflammatory bowel disease

    Massachusetts General Hospital (MGH) and Harvard Medical School investigators have found that infusions of a particular bone marrow stem cell appeared to protect gastrointestinal tissue from autoimmune attack in a mouse model.

  • Researchers find sleep selectively preserves emotional memories

    As poets, songwriters and authors have described, our memories range from misty water-colored recollections to vividly detailed images of the times of our lives. Now, a study led by Harvard…

  • Women in India abused by husbands at far greater risk for HIV infection

    In a new study, researchers at the Harvard School of Public Health (HSPH) have found that married Indian women who experienced physical and sexual abuse at the hands of their…

  • A rare glimpse of schizophrenia’s genetic roots

    The delusions and hallucinations of schizophrenia can be devastating for the 1% of the population struck by the disease. The condition clearly has a genetic component, evidenced by its tendency…

  • Microsoft gives Partners grant for diabetes home-health program

    The Center for Connected Health, a division of Partners HealthCare, one of the nation’s leading integrated health care delivery systems, received funding from the Microsoft HealthVault Be Well Fund to…

  • Growth hormone reduces abdominal fat, cardiovascular risk factors in HIV patients on antiviral therapy

    Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat…

  • MGH study shows how amyloid plaques may damage brain cells in Alzheimer’s disease

    One of the major unanswered questions surrounding Alzheimer’s disease – whether and how the amyloid plaques found in the brains of patients with the neurodegenerative disorder actually damage neurons – may be closer to an answer.

  • Science in brief

    Researchers identify promising cancer drug target in prostate tumors; Scientists find how neural activity spurs blood flow in the brain: Newfound mechanisms could bolster understanding of brain imaging, aging’s effects; World Health Organization creates new surgical tool to make operations safer everywhere; Invasive treatment appears beneficial for men and high-risk women with certain type of acute coronary syndromes; International team identifies 21 new genetic risk factors for Crohn’s disease: Study combines efforts of three research groups, brings total risk sites to 32; Relaxation response can influence expression of stress-related genes: Genomic study finds common biological basis for effects of mind/body practices

  • When threatened, a few African frogs can morph toes into claws

    Biologists at Harvard University have determined that some African frogs carry concealed weapons: When threatened, these species puncture their own skin with sharp bones in their toes, using the bones as claws capable of wounding predators.

  • Broad Institute earns grant to support pathbreaking diabetes study

    Researchers at the Broad Institute of Harvard and MIT have received a grant to support novel, integrative research aimed at finding ways to encourage the human body to replenish the cells that are missing in type 1 diabetes.

  • Young smokers recruited with menthol, study finds

    Researchers at Harvard School of Public Health (HSPH) explored tobacco industry manipulation of menthol levels in specific brands and found a deliberate strategy to recruit and addict young smokers by adjusting menthol to create a milder experience for the firsttime smoker.

  • Genetic mechanisms linked to Parkinson’s disease uncovered

    A new genetic finding from a group of researchers at Brigham and Women’s Hospital (BWH), the University of Wisconsin School of Medicine and Public Health (SMPH), and the University of Ottawa may help pave the way for the discovery of therapies that could effectively treat Parkinson’s disease (PD).

  • Across species, genes evolve to minimize protein production errors

    Scientists at Harvard University and the University of Texas, Austin, have found that genetic evolution is strongly shaped by genes’ efforts to prevent or tolerate errors in protein production.

  • GlaxoSmithKline and Harvard Stem Cell Institute announce major collaboration agreement

    GlaxoSmithKline (GSK) and the Harvard Stem Cell Institute (HSCI) today announced that they have entered into a five-year, $25 million-plus collaborative agreement to build a unique alliance in stem cell…

  • BWH Asthma Research Center Awarded $2 Million Grant for Gene-based Clinical Trial; participants sought from Partners’ Network

    The Brigham and Women’s Hospital Asthma Research Center (ARC) has received a $2 million Genetics Enters Medicine (GEM) grant from Partners to study the influence of one’s genetic profile on…

  • Tobacco industry used cigarette menthol to recruit new adolescents and young adult smokers

    Researchers at Harvard School of Public Health (HSPH) have found that tobacco companies have deliberately adjusted menthol levels in cigarettes to recruit and addict young smokers by creating a milder…

  • Amy Wagers – focusing on stem cell biology

    Twenty minutes after her weekly lab meeting is scheduled to begin, Amy Wagers rushes into a conference room on the fourth floor of the Joslin Diabetes Center, where her lab…

  • Stem cells used to treat muscular dystrophy in mice

    Harvard Stem Cell Institute researchers at the Joslin Diabetes Center have for the first time demonstrated that transplanted muscle stem cells can both improve muscle function in mice with a…