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  • Study adds to the understanding of musical pitch perception

    There are differences in the sounds of two voices or two musical instruments even if they hit the same note, and somehow the brain knows that. A new study shows…

  • Study upends earlier thinking about immune cell’s readiness against disease

    A type of disease-fighting cells in the body — T cells — have a reputation for being ever-ready to fight invading infections. But that’s not the way they really work,…

  • Researchers explain how protein inhibits growth of blood vessels

    Thirty years ago, Judah Folkman, of Children’s Hospital Boston and Harvard Medical School, first developed the idea that cancerous tumors are dependent on the growth of small blood vessels. Since…

  • Study reveals how child abuse can lead to substance abuse

    It’s a common-sense notion that those who have been abused as children may became drug abusers later in life. But why is this so? Carl Anderson, a Harvard instructor in…

  • Study finds embryonic stem cells can repair heart muscle

    Heart failure develops when the heart stops pumping effectively due to the destruction of muscle cells, known as cardiomyocytes. Damage inflicted during a heart attack causes massive loss of cardiomyocytes,…

  • High levels of Epstein-Barr virus antibodies in women linked to risk of multiple sclerosis

    Multiple sclerosis is a chronic degenerative disease of the central nervous system. Nationwide, there are an estimated 250,000 to 350,000 people with MS. Researchers have long wondered how MS develops…

  • Pain and pleasure activate same brain structures

    David Borsook is a Harvard Medical School associate professor of radiology, who both treats patients and conducts research. “Over 15 years of seeing patients with pain it became obvious that…

  • Technique enables quick accounting of gene function

    Now that whole genomes have been sequenced, a group of scientists has geared up for the next phase: identification and classification of newly discovered coding regions. The DNA microchip, developed…

  • Polarity gene yields clues to organization of cell signaling, structural growth

    Researchers are beginning to understand how a gene called “stardust” works to set up the basic top-down architecture of the epithelial cells that line the gut, skin, and many other…

  • Sickle cell disease cured in mouse model

    Sickle cell disease is a blood disorder caused by a single mutation in the beta-globin gene that results in the substitution of one amino acid. This small error is enough…

  • Lithium drugs found to reduce suicide risk

    Researchers who wondered about the effectiveness of lithium drugs in treating patients with severe depression analyzed 22 studies involving 5,647 patients. The scientists, working at Harvard-affiliated McLean Hospital in Belmont,…

  • Early exposure to Ritalin may blunt desire for cocaine later in life

    There are several controversies surrounding the use of Ritalin, or methylphenidate, a stimulant prescribed for children who have an abnormally high level of activity or attention deficit hyperactivity disorder (ADHD).…

  • Trying to prevent mother-to-child transmission of HIV

    Harvard AIDS Institute researchers in Botswana are trying to help HIV-infected mothers and their infants. In the rural area of Molepolole, where AIDS Institute researcher Shahin Lockman lives and works,…

  • Comprehensive set of vision genes discovered

    Using a computer program that compares bits of genetic material taken from tissue in the retinas of mice against records in a huge genetic data base from the mouse and…

  • Whole genes delivered to cells

    To make a protein, a cell’s enzymes typically edit out about 90 percent of the information along the length of a DNA strand that makes up a whole gene. In…

  • “Commoner” in brain crowns the cortex

    With its role in higher cognitive functions, the cortex represents a significant evolutionary development in mammals, culminating in the enlarged hemispheres of humans and other primates. In the development of…

  • The fruit fly fight club

    Fruit flies fight. The males will go after each other, fighting to establish dominance. Edward Kravitz, the George Packer Berry professor of neurobiology at Harvard Medical School, is using the…

  • Remote-control immunity up close

    When we receive a wound, disease-fighting cells rush to the scene to do combat with bodily invaders. But how does this work? When we receive a wound, cells near the…

  • Research suggests optimistic attitude can reduce risk of heart disease in older men

    Researchers from the Harvard School of Public Health, working with colleagues from the Department of Veterans Affairs, studied some 1,306 Boston area men who were part of the Veterans Affairs…

  • HIV-1 infected children benefit greatly from combination therapy

    Combination therapy including protease inhibitors has been available since 1996 for adults with HIV-1 infection. The therapy has slowed the progression of HIV-1 and drastically reduced the rate of mortality…

  • Immune system discovery may lead to preventive therapy for diabetes

    The job of cells known as iNKT cells is to regulate the immune system’s response to infections and other disorders, ensuring that only diseased tissue, not healthy tissue, is targeted…

  • No innocent bystanders

    When cancer cells begin to do their destructive work, they have accomplices — normal cells that help nourish the cancerous ones. As Jack Lawler, Harvard Medical School associate professor of…

  • Cell protein potently blocks enzyme linked to cancer

    The ends of chromosomes in normal cells eventually unravel, causing the cells to die. This does not happen in cancer cells, however. Cancer cells use an enzyme named telomerase to…

  • Dopamine may play dual role in Parkinson’s disease

    According to the Parkinson’s Disease Foundation, “Parkinson’s disease (PD) is a disorder of the central nervous system that affects between one and one-and-a-half million Americans. Because it is not contagious…

  • “Heart of glass” may be more than just a metaphor

    Jeffrey Fredberg is a professor of bioengineering and physiology at the Harvard School of Public Health. His primary research interest is asthma. Fredberg was intrigued by the plasticity of the…

  • WHO report reviews world mental health care

    Since the mid-1970s, World Health Organization policies have encouraged integrating mental health services into primary care settings. But no one knows what, if anything, might be working to help those…

  • How does the brain reinvent itself?

    In order for us to use our minds for memory, for learning, and so forth, our brains must continually reinvent themselves. How do they do it? A Harvard Medical School…

  • Anthrax toxin receptor discovered

    The first point of contact between anthrax toxin that invades the body and the cells that the toxin will eventually destroy is a protein, known as a “docking” protein or…

  • Cognition unaffected by marijuana use

    Harrison Pope, a Harvard professor of psychiatry, and his colleagues at McLean Hospital, a Harvard-affiliated psychiatric facility in Belmont, Mass., investigated the long-term cognitive effects of smoking marijuana. They recruited…

  • Cardiovascular risks seen from marathon running

    Researchers analyzed the blood of marathon runners less than 24 hours after they had finished a race. They found abnormally high levels of inflammatory and clotting factors of the kind…