Featured series 
Tag: Genetics
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Health
Schepens scientists first to discover angiogenesis switch inside blood vessel cells
Scientists at Schepens Eye Research Institute, an affiliate of Harvard Medical School, are the first to discover a switch inside blood vessel cells that controls angiogenesis (new blood vessel growth).…
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Health
Scientists discover new genetic subtypes of common blood cancer
Scientists at Dana-Farber Cancer Institute and collaborators have identified four distinct genetic subtypes of multiple myeloma, a deadly blood cancer, that have different prognoses and might be treated most effectively…
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Health
X inactivation seen as contact sport
At an early stage in a female embryo’s development, one of the two X chromosomes in each of its cells becomes inactivated. In two recent papers, the lab of Jeannie…
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Health
RNA sequence restrains fatal encephalitis
One short sequence of RNA protected mice from deadly brain inflammation caused by West Nile virus and Japanese encephalitis virus, report Priti Kumar, Manjunath Swamy, and Premlata Shankar. The findings,…
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Health
Binge eating disorder may have genetic ties
Researchers at Harvard-affiliated McLean Hospital have reported that binge eating disorder runs in families, raising the possibility that this condition may have a genetic basis. In the study, published in…
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Health
DNA copier component found to be real drag
A study in the Feb. 2, 2006 Nature by Antoine van Oijen’s lab sheds light on a longstanding puzzle in DNA replication: how do the enzymes that copy the two…
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Arts & Culture
Brigham pilot program connects people with family histories
A Harvard Medical School instructor at Brigham and Women’s Hospital is spearheading a pilot project to encourage Brigham employees to gather detailed family health histories to give health care officials an edge fighting inherited diseases.
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Health
Dog genome unleashed
An international research team led by scientists at the Broad Institute of MIT and Harvard has decoded the DNA of the domestic dog and pinpointed millions of genetic differences that…
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Health
Lab moves genomic testing into the clinic
The earliest symptom of the inherited heart condition hypertrophic cardiomyopathy can be sudden death at a tragically young age. Harvard Medical School researchers discovered the first human gene underlying the…
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Science & Tech
Early steps discovered in protein-making process
Translation, the synthesis of protein from an mRNA template, has long been considered a benign sequela to transcription. After all, dysregulation of transcription causes a multitude of human disorders, including…
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Campus & Community
Bulyk searches for DNA on-off switches
Martha Bulyk held what looked like an ordinary glass slide up to the large window that is much of one wall of her Harvard Medical School office. The slide seemed…
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Campus & Community
HapMap reveals roots of common diseases
The genes that everyone inherits contain coded information that influences which diseases any individual is most at risk of getting. Countless studies show that small variations in genes play a…
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Campus & Community
HapMap: First look at ‘order in variety’ of human genome
The completion of the human genome sequence in 2003, though momentous, was only the first step toward grasping the core mechanisms of human biology and disease. This ultimate biomedical goal…
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Science & Tech
First edition of HapMap released
A flurry of high-profile scientific manuscripts published in October 2005 describe both the content and uses of HapMap, a catalog that maps human genetic variation and relates it both to…
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Campus & Community
Chimp genome effort shines light on human evolution
A research effort, led by scientists at the Broad Institute of MIT and Harvard, the Washington University School of Medicine in St. Louis, and the University of Washington, Seattle, focused…
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Science & Tech
Genome scanning technique spots disease risk
A new technique, admixture mapping, takes advantage of the higher-risk genetic segments from one population that show up in the other through generations of racial mixing. The presence of higher-risk…
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Science & Tech
Harvard, MGH researchers track egg cell production to marrow
In a series of experiments on sterile female mice, Massachusetts General Hospital (MGH) researchers were able to restore egg production by transplanting bone marrow from fertile mice. The researchers believe…
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Health
Subtle changes in normal genes implicated in breast cancer
Scientists found that benign cells surrounding breast cancers undergo epigenetic modifications. The altered gene function causes the microenvironment cells to signal proliferation and increased aggression in the breast tumor cells.…
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Health
Scientists identify normal gene driving the growth and survival of melanoma cells
Dana-Farber’s Levi Garraway, M.D., Ph.D., and William Sellers, M.D., the paper’s first and senior authors, and their colleagues reported their findings in the July 7, 2005 issue of the journal…
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Health
DNA-scanning technology finds possible sites of cancer genes in chromosomes of lung cancer cell
In a study in the July 1, 2005 issue of the journal Cancer Research, the researchers used single nucleotide polymorphism (SNP) array technology to identify regions of chromosomes where genes…
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Health
Disease mutation tracked down, ending ‘curse’ for Colombian families
Three years later, Joseph Arboleda-Velasquez, an HMS graduate student who led the scientific team that identified the mutations, and his collaborators have worked out an early step in the events…
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Health
Gene clue to brain asymmetry revealed on right side
Although many assumed that the asymmetry-producing genes, when found, would be more highly expressed on the left side of the brain than the right, Sun Tao, Christopher A. Walsh, and…
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Health
‘Brown fat’ cells hold clues for possible obesity treatments
In laboratory studies of mouse cells, the research team identified genes that govern how precursor cells give rise to mature brown fat cells. There are two main types of fat…
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Health
Left- or right-brain? Genes may tell the story
According to HHMI investigator Christopher A. Walsh, postdoctoral fellow Tao Sun, and their colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School, their discovery that a gene called…
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Health
TB susceptibility gene identified
As many as one out of three people in the world are infected with the bacteria that causes tuberculosis, public health experts estimate. That could lead to a global plague…
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Health
Joslin Diabetes Center scientists find genetic defects in immunological tolerance
The genetic defect keeps the body from properly dealing with “errant” immune cells that it normally eliminates by a process called immunological tolerance. These immune cells then attack the insulin-producing…
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Health
Researchers find better way to predict stroke risk in sickle cell anemia patients
Researchers from Children’s Hospital Boston, Boston University School of Public Health (BUSPH), Boston University School of Medicine (BUSM), Boston Medical Center (BMC) and Harvard Medical School have developed a novel…
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Health
Largest twin study of age-related macular degeneration finds genetics and environment play large role in disease
Researchers led by Johanna M. Seddon, M.D., at the Massachusetts Eye and Ear Infirmary, Harvard Medical School and Harvard School of Public Health conducted the largest study of twins of…
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Campus & Community
Researchers devise cheaper way to make genes
Harvard researchers have devised a way to greatly decrease the cost of making artificial genes in the laboratory, an advance that could increase the ability of geneticists to explore and…