Featured series 
Tag: Department of Pathology
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Nation & World
Three-dimensional, miniature endoscope opens new diagnostic possibilities
Massachusetts General Hospital (MGH) researchers have developed a new type of miniature endoscope that produces three-dimensional, high-definition images, which may greatly expand the application of minimally invasive diagnostic and therapeutic…
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Nation & World
Bulyk searches for DNA on-off switches
Martha Bulyk held what looked like an ordinary glass slide up to the large window that is much of one wall of her Harvard Medical School office. The slide seemed…
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Nation & World
Depression linked to previously unknown dopamine regulator
Li-Huei Tsai, Harvard Medical School (HMS) professor of pathology, HMS research fellow Sang Ki Park, and colleagues worked with mice and found a novel function for the molecule Par-4 (prostate…
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Nation & World
Protein packages activate genes
It’s all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and M.I.T. They did the largest, most…
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Nation & World
Disparate proteins structurally identical
Gerhard Wagner, the Elkan Blout professor of biological chemistry and molecular pharmacology, and Tucker Collins, the S. Burt Wolbach professor of pathology at Harvard Medical School and Children’s Hospital, made…
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Nation & World
Protein reverses engineering of chromosome structure
An enzyme, a histone demethylase, removes methyl groups appended to histones, nuclear proteins that organize DNA and regulate gene activity. Methyl groups and other chemical tags on histones regulate how…
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Nation & World
Surprising variations discovered in human genomes
Researchers from Harvard Medical School and the University of Toronto in Canada looked at 55 healthy, unrelated men and women, and they discovered 255 regions with relatively large gains or…
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Nation & World
Wine molecule slows aging process
Called resveratrol, a wonder substance discovered by Harvard researchers seems to work in the same way as does drastic calorie cutting. Dramatic reduction of calories has been shown to increase…
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Nation & World
Eating less and living longer
Tantalizing evidence exists that cutting calories by 20 percent helps monkeys, who are close relatives, to live longer, healthier lives. And, in one nonscientific program, adults are reducing their caloric…
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Nation & World
Glowing mouse shows how immune alarm rallies troops against invasion
In the body, dendritic and other antigen-presenting cells initially handle all infections in the body. The dendritic cells lurk in the skin, lungs, gut, and other tissues. On sentry duty,…
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Nation & World
New molecular model increases longevity and could allow you to eat cake, too
Scientists have known about the longevity benefits of caloric restriction since experiments in the 1930s showed that rats lived much longer if their food intake was severely restricted. Broadly speaking,…
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Nation & World
New tool speeds study of mammalian protein function
A new technology developed by Harvard Medical School researchers in the laboratory of Yang Shi, associate professor of pathology, extends the range of possibilities of selective interference of gene expression…
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Nation & World
Discovery could aid in therapeutic cloning, clamping down on cancer
“Our focus is to understand the very first few steps that drive a cell to become an intestinal cell instead of a muscle cell,” says Yang Shi, Harvard Medical School…
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Nation & World
No innocent bystanders
When cancer cells begin to do their destructive work, they have accomplices — normal cells that help nourish the cancerous ones. As Jack Lawler, Harvard Medical School associate professor of…
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Nation & World
Cancer cells’ immortality may depend on longevity protein
A team of Harvard Medical School researchers has identified a protein that 10 percent of tumor cells use to attain an immortal state. By blocking the molecule, it may be…