“It’s great to see him play a part that’s as much about listening as it is about talking,” said Wilson. Still, every time Jones speaks in that famous resonant basso, added the director, “the whole cast just looks.”

Ashley, a longtime friend to Williams, had her breakout Broadway performance in 1974 when she portrayed Maggie in the playwright’s “Cat on a Hot Tin Roof,” and has since been in numerous Williams plays. As such, the actor brings “authenticity and authority,” to “Iguana” said Wilson. “She knows Tennessee’s music and rhythms, and she knows exactly how to drive through them.

“You feel Tennessee laughing on her shoulder,” he added.

Ashley also knows Wilson well. In 2001, Wilson led the Hartford Stage’s production of “The Glass Menagerie,” with Ashley in the role of faded Southern belle Amanda Wingfield. The show played at the A.R.T. and went on to win an Elliot Norton Award. The A.R.T. mounted an acclaimed production of “Menagerie” in 2013 that went on to a successful Broadway run.

Plummer also knows this landscape well. She and Wilson have done three Williams plays together. Plummer also starred in a 1983 Broadway production of “The Glass Menagerie” with Jessica Tandy. While Plummer knows what Ashley, Vivien Leigh, Geraldine Page, and Barbara Bel Geddes have achieved in leading Williams’ roles, what’s fun to watch, Wilson said, is Plummer “doing it her way.”

“She’s been very effective, and really arresting the audience’s attention.”

The director called Delany, winner of back-to-back Emmys for her work on the television drama “China Beach,” “a damn good stage actress.”

“From the time I talked to her on the phone when we were exploring her coming out here to do this,” recalled Wilson, “I knew she had the right chutzpah, energy, guts, courage, and humor to play Maxine.”

Of Heck, the play’s fallen preacher, Wilson said, “He’s becoming one of the main actors of his generation, and this Shannon is going to catapult him out of the earnest Gary Cooper kind of character into more of a James Dean bad boy.”

A Southerner himself, Wilson knows Williams’ works inside and out, producing an ambitious marathon of them as artistic director of the Hartford Stage from 1998 to 2011, regularly staging well-known plays alongside lesser-known one-act works and more abstract creations.

On a break from A.R.T. rehearsals, Wilson explained his longtime love for Williams’ repertoire.

“He wrote as many full-length plays as Shakespeare. He wrote a number of one-act plays as well as short stories. Many of the short stories and one-acts are sketches for the full-length plays. He also wrote novels and screenplays. He was just a very prolific writer.”

He was also profound. Williams tapped into the human condition like no other, said Wilson, and his themes still resonate.

“With what’s happening in our world today, where law-and-order governments seem to be on the rise not just in the United States but in other countries throughout the rest of the world, anything that has ambiguity of any sort — moral, sexual, gender, thought — there’s really not going to be a lot of room for that. And that’s dangerous to people who are sensitive and empathetic,” said Wilson. “And I think it’s just yet another incredible way in which this play is prescient and vitally relevant today.”

Wilson first worked with Airaldi more than 20 years ago at the A.RT. The director has a keen eye for Williams’ sensibilities, said Airaldi, and appreciates the playwright’s ability to combine the type of lyricism found in Shakespeare with the kinds of compelling silences favored by playwrights such as Anton Chekov.

Airaldi, who has been in a number of Wilson-directed Williams productions over the years, said he often uses scenes from Williams’ works in his Harvard acting classes. The writing, he said, combines “everything that an actor needs to do.” It’s the language, said Airaldi, who plays travel company representative Jake Latta in the third act. But it’s also “what’s under the words, the silences around them.”

Airaldi said that Williams “shows such a compassion for the misfits in life. … Most of us in theater, if you dig deep enough, you’ll find a misfit somewhere.”

For a further window into Williams and his work, audience members can check out the small display in the Loeb Drama Center’s lobby. The exhibit will feature material from the collection of Williams ephemera and manuscripts housed at Harvard’s Houghton Library.

“We hope the display will give audiences a sense of how long the development process was for ‘Iguana,’ ” said Annabeth Lucas, the A.R.T. Institute’s production dramaturg, “as well as a little insight into Williams’ tendency to constantly revise his own work.”

“The Night of the Iguana” will play at the Loeb Drama Center on Tuesdays through Sundays, Feb. 18 through March 18. Tickets are available here.