Health
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Why bother?
What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.
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Stopping the bleeding
Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’
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Immune-system strategy used to treat cancer may help with Alzheimer’s
Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice
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Is dining with others a sign of happiness?
Shared meals may be a more reliable indicator of well-being than income, Kennedy School researcher says
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Researchers ID genetic disorders that can be treated before birth
Timely detection could reduce morbidity, offer opportunities for early intervention
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How to manage stress during an apocalypse
Psychologist says scrutinizing risk factors, embracing community, adventure are key in age of angst over climate, AI, pandemics
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Explosion of child obesity predicted to shorten U.S. life expectancy
A review by obesity researcher David Ludwig of Children’s Hospital Boston, epidemiologist S. Jay Olshansky of the University of Illinois at Chicago, and colleagues concludes that obesity now reduces average…
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Preventive removal of both breasts reduces chance of breast cancer in women at elevated risk
“Prophylactic mastectomy appears very effective in preventing breast cancer but choosing this procedure is a complex decision,” said Ann M. Geiger, PhD, lead author of the study. “Prophylactic mastectomy prevents…
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Weight status of children ages 8 to 15 predicts obesity and high blood pressure in adulthood
“We have known that kids who are overweight or obese have a higher risk for being overweight or obese as adults. But in this paper, we show that even children…
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Largest twin study of age-related macular degeneration finds genetics and environment play large role in disease
Researchers led by Johanna M. Seddon, M.D., at the Massachusetts Eye and Ear Infirmary, Harvard Medical School and Harvard School of Public Health conducted the largest study of twins of…
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Protein packages activate genes
It’s all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and M.I.T. They did the largest, most…
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Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
To understand the increased risk factor, the researchers mated ordinary mice and separated the mothers into a control group that ate as much chow as they wanted throughout their pregnancies…
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Urine test tracks deadly birthmarks
Although not yet approved by the Food and Drug Administration, results from simple urine tests are already being used to guide treatment of children with disfiguring birthmarks and adults with…
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Key to dental enamel formation found
Scientists at Harvard-affiliated Forsyth Institute have found and replicated a key aspect of the mechanism by which dental enamel is formed. The findings, published in the Feb. 14 Journal of…
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Schepens scientists regenerate optic nerve for the first time
In earlier research, Dr. Dong Feng Chen, lead author of the study, assistant scientist at Schepens Eye Research Institute and an assistant professor of ophthalmology at Harvard Medical school, and…
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How often should women get mammograms?
With screening guidelines and financial coverage varying among health systems and insurers – sometimes dramatically – a new mathematical model provides quantitative predictions of the mortality benefits, on average, in…
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Long-term Celebrex use increases cardiovascular event risk
The findings prompted the suspension of Celebrex within the Adenoma Prevention with Celecoxib (APC) Trial, in which participants were to take celecoxib or placebo for three years. “These data suggest…
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Older doctors less likely to follow current standards of care
The study included a review of previously published papers with a large sample size of doctors. These studies included measures of physician knowledge or quality of care as well as…
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Food ingredients may be as effective as antidepressants
Researchers report that omega-3 fatty acids and uridine, two substances in foods such as fish, walnuts, molasses, and sugar beets, prevented depression in rats as effectively as antidepressant drugs. “Giving…
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Phobic anxiety increases risk of sudden cardiac death in women
According to lead author Christine M. Albert, M.D., M.P.H., an epidemiologist at BWH and an electrophysiologist and cardiologist at MGH, “Phobic anxiety is associated with coronary heart disease risk factors.…
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Weight and weight gain may predict breast cancer survival
The study included 5,204 women with invasive breast cancer who were between the ages 30 to 55 when enrolled in the study in 1976. The researchers found that women who…
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Scientists discover “master switch” that triggers insulin resistance and type 2 diabetes
“We zeroed in on a factor called NF-kB,” said principal investigator Steven E. Shoelson, M.D., Ph.D., Helen and Morton Adler Chair and head of the Section on Cellular and Molecular…
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Study says women don’t experience pain, anxiety during mammograms
“I think it’s an old wives tale that mammograms hurt,” says the study’s lead author, Alice Domar, PhD, director of the Mind/ Body Center for Women’s Health at Boston IVF…
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Snaring secrets of the Venus flytrap
While “speed” is not a word most people associate with the plant kingdom, the Venus flytrap closes its v-shaped leaves in just one-tenth of a second – fast enough to…
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Weight gain and obesity linked to higher risk of kidney stones
“Our study demonstrated that multiple measures of larger body size, including larger waist circumference, higher weight, and higher body mass index, were related to an elevated risk of kidney stones,”…
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Solving the mystery of a centuries-old plague
Edward O. Wilson identified two different ant species in investigating the mystery of centuries-old plagues, a tropical fire ant in the early 1500s and an introduced African ant in the…
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Safer cigarettes would cut fire deaths if made available
Researchers at Harvard School of Public Health, funded by the American Legacy Foundation, compared the physical properties of cigarettes sold in New York with cigarettes of the same brands sold…
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First view of many neurons processing information in living brain
A Harvard Medical School (HMS) research team used a new technique to obtain the first close-up look at the neural circuits that produce vision in cats and rats. “Put simply,…
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One alcoholic drink per day improves cognitive function among older women
According to the study’s senior author, BWH’s Francine Grodstein, Sc.D., “Much evidence has demonstrated the heart benefits of light alcohol drinking, but less research has focused on cognitive functioning. While…
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Monitoring system needed to prevent safety hazard of problem physicians
Asserting that “physician performance failures are not rare and pose substantial threats to patient welfare and safety,” experts in medical error are calling on state medical boards and healthcare organizations…
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Findings recommend herpes vaccine for human trials
Research published in the January 2005 Journal of Virology compared three different experimental vaccines for herpes simplex virus 2 (HSV-2), which causes most cases of genital herpes. Lead author Stephen…
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Disparate proteins structurally identical
Gerhard Wagner, the Elkan Blout professor of biological chemistry and molecular pharmacology, and Tucker Collins, the S. Burt Wolbach professor of pathology at Harvard Medical School and Children’s Hospital, made…
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RNA-making apparatus seen to uncoil and recoil DNA
Eukaryotic cells like to keep their DNA under wraps, winding the long strands of nucleic acid around millions of little protein complexes. This bead-on-a-string structure, called chromatin, ensures that the…
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One third of U.S. adults use complementary and alternative medicines
The continued widespread use of individual and multiple CAM therapies underscores the need to rigorously evaluate the safety, efficacy, and cost-effectiveness of these approaches, according to the study’s lead author…
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Protein in urine may warn of preeclampsia risk in pregnant women
Preeclampsia, or toxemia, develops during pregnancy. In severe cases, it can rapidly escalate to eclampsia, a condition in which the mother suffers a series of potentially fatal complications. Ananth Karumanchi,…
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Researchers discover why we go gray
People turn gray, Harvard scientists found, when certain adult stem cells gradually die off. The stem cells provide a continuous supply of other, pigment-producing cells that give your hair its…