Tissues such as muscle and brain convert the inactive form of thyroid hormone, T4, into T3, the active form of thyroid hormone, when necessary. In the 1980s, researchers discovered that…
Scientists found that benign cells surrounding breast cancers undergo epigenetic modifications. The altered gene function causes the microenvironment cells to signal proliferation and increased aggression in the breast tumor cells.…
The PKC-Diabetic Retinopathy Study (DRS) was designed to evaluate the safety and effect of an oral treatment, RBX, on retinopathy progression or visual loss in patients with moderately severe to…
After decades of surviving peer rejection of his theory of cancer treatment by blocking tiny blood vessels, Judah Folkman has gone on to develop drugs that did what he predicted…
Individuals respond with physical and emotional distress to situations that recall traumatic memories. Such responses usually diminish gradually, as those situations are repeated without unpleasant occurrences; this is called “extinction…
The WHS trial was led by BWH researchers Nancy Cook, Sc.D., and Julie Buring, Sc.D. Its results are published in the July 6, 2005 Journal of the American Medical Association.…
Dana-Farber’s Levi Garraway, M.D., Ph.D., and William Sellers, M.D., the paper’s first and senior authors, and their colleagues reported their findings in the July 7, 2005 issue of the journal…
Vascular anomalies include both vascular malformations and vascular tumors (most commonly hemangiomas). Hemangiomas, found in about 10 percent of infants, occur when the cells lining blood vessels multiply abnormally. Hemangiomas…
The Brookline Early Education Program (BEEP), a community- based child health and development program, was initiated by the Brookline Public Schools and the Robert Wood Johnson Foundation and ran from…
In a study in the July 1, 2005 issue of the journal Cancer Research, the researchers used single nucleotide polymorphism (SNP) array technology to identify regions of chromosomes where genes…
Researchers led by Johanna M. Seddon, M.D., at the Massachusetts Eye and Ear Infirmary, Harvard Medical School, and Harvard School of Public Health, conducted a prospective longitudinal study to examine…
Three years later, Joseph Arboleda-Velasquez, an HMS graduate student who led the scientific team that identified the mutations, and his collaborators have worked out an early step in the events…
Although many assumed that the asymmetry-producing genes, when found, would be more highly expressed on the left side of the brain than the right, Sun Tao, Christopher A. Walsh, and…
The two patients were part of a small exploratory study in Halifax. In the study, the cells were bathed in the trophic factor GDNF before being implanted into the striatum,…
In recent work, Myles Brown and colleagues combined chromatin immunoprecipitation (ChiP) assays with measures of DNA structure and large-scale gene chip analyses to study where, when, and how androgen and…
The researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Velcade and an experimental compound that was designed by researchers at the Broad…
For the study, the researchers analyzed 663 patients who were examined on CT for suspected appendicitis. An appendectomy was performed on 268 of the CT-screened patients. Of these 268 patients,…
In laboratory studies of mouse cells, the research team identified genes that govern how precursor cells give rise to mature brown fat cells. There are two main types of fat…
Exercise plays a role in preventing breast cancer, and research strongly suggests that breast cancer patients who are more physically active improve their self-esteem and body image. Now, a landmark study from the Brigham and Women’s Hospital (BWH) finds that exercise after diagnosis may help breast cancer patients live longer.
“There have been several news stories and reports from insurers claiming that imaging costs are catching and even surpassing drug costs as major drivers of health care inflation,” says Scott…
Repetitive transcranial magnetic stimulation treatment improved motor function in a small group of people. For the stimulation, an insulated wire coil is placed on the scalp, and an electrical current…
As many as one out of three people in the world are infected with the bacteria that causes tuberculosis, public health experts estimate. That could lead to a global plague…
Although adult muscle cells become inflexible after differentiation, these cells temporarily loosen the structure to divide in fetal development. Mark T. Keating found that in some lower vertebrates, heart tissue…
Keeping an animal functioning after a cervical spinal cord injury is nearly impossible. An American researcher developed the lower spinal cord rat model in the early 1900s. He found that…
Joslin Diabetes Center researchers Diane Mathis’s and Christophe Benoist’s finding that the lymph node draining the pancreas was intrinsic to the autoimmune response in mice made David Hafler, HMS professor…
“Our data are intriguing because they showed that aspirin use notably reduced the risk of recurrence in patients with advanced colon cancer, but more research is needed before any treatment…
Previous studies have shown that using combination chemotherapy of cisplatin and 5-fu yields a 25 to 50 percent rate of complete pathological responses (the tumor disappeared). Robert Haddad, M.D., and…
According to HHMI investigator Christopher A. Walsh, postdoctoral fellow Tao Sun, and their colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School, their discovery that a gene called…
A study published in the May 10, 2005, Current Biology has ramifications for neuroscience, developmental genetics, evolutionary biology and, possibly, human teratology (a branch of pathology and embryology concerned with…
A report from researchers at Massachusetts General Hospital (MGH), Harvard School of Public Health (HSPH) and Brigham and Women’s Hospital (BWH) – the first large-scale, prospective examination of a relationship…
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