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  • MGH study shows how amyloid plaques may damage brain cells in Alzheimer’s disease

    One of the major unanswered questions surrounding Alzheimer’s disease – whether and how the amyloid plaques found in the brains of patients with the neurodegenerative disorder actually damage neurons – may be closer to an answer.

  • Science in brief

    Researchers identify promising cancer drug target in prostate tumors; Scientists find how neural activity spurs blood flow in the brain: Newfound mechanisms could bolster understanding of brain imaging, aging’s effects; World Health Organization creates new surgical tool to make operations safer everywhere; Invasive treatment appears beneficial for men and high-risk women with certain type of acute coronary syndromes; International team identifies 21 new genetic risk factors for Crohn’s disease: Study combines efforts of three research groups, brings total risk sites to 32; Relaxation response can influence expression of stress-related genes: Genomic study finds common biological basis for effects of mind/body practices

  • When threatened, a few African frogs can morph toes into claws

    Biologists at Harvard University have determined that some African frogs carry concealed weapons: When threatened, these species puncture their own skin with sharp bones in their toes, using the bones as claws capable of wounding predators.

  • Broad Institute earns grant to support pathbreaking diabetes study

    Researchers at the Broad Institute of Harvard and MIT have received a grant to support novel, integrative research aimed at finding ways to encourage the human body to replenish the cells that are missing in type 1 diabetes.

  • Young smokers recruited with menthol, study finds

    Researchers at Harvard School of Public Health (HSPH) explored tobacco industry manipulation of menthol levels in specific brands and found a deliberate strategy to recruit and addict young smokers by adjusting menthol to create a milder experience for the firsttime smoker.

  • Genetic mechanisms linked to Parkinson’s disease uncovered

    A new genetic finding from a group of researchers at Brigham and Women’s Hospital (BWH), the University of Wisconsin School of Medicine and Public Health (SMPH), and the University of Ottawa may help pave the way for the discovery of therapies that could effectively treat Parkinson’s disease (PD).

  • Across species, genes evolve to minimize protein production errors

    Scientists at Harvard University and the University of Texas, Austin, have found that genetic evolution is strongly shaped by genes’ efforts to prevent or tolerate errors in protein production.

  • GlaxoSmithKline and Harvard Stem Cell Institute announce major collaboration agreement

    GlaxoSmithKline (GSK) and the Harvard Stem Cell Institute (HSCI) today announced that they have entered into a five-year, $25 million-plus collaborative agreement to build a unique alliance in stem cell…

  • BWH Asthma Research Center Awarded $2 Million Grant for Gene-based Clinical Trial; participants sought from Partners’ Network

    The Brigham and Women’s Hospital Asthma Research Center (ARC) has received a $2 million Genetics Enters Medicine (GEM) grant from Partners to study the influence of one’s genetic profile on…

  • Tobacco industry used cigarette menthol to recruit new adolescents and young adult smokers

    Researchers at Harvard School of Public Health (HSPH) have found that tobacco companies have deliberately adjusted menthol levels in cigarettes to recruit and addict young smokers by creating a milder…

  • Amy Wagers – focusing on stem cell biology

    Twenty minutes after her weekly lab meeting is scheduled to begin, Amy Wagers rushes into a conference room on the fourth floor of the Joslin Diabetes Center, where her lab…

  • Stem cells used to treat muscular dystrophy in mice

    Harvard Stem Cell Institute researchers at the Joslin Diabetes Center have for the first time demonstrated that transplanted muscle stem cells can both improve muscle function in mice with a…

  • Middle Eastern families yield intriguing clues to autism

    Research involving large Middle Eastern families, sophisticated genetic analysis and groundbreaking neuroscience has implicated a half-dozen new genes in autism. More importantly, it strongly supports the emerging idea that autism…

  • Scientists use genomic tools to create maps of DNA methylation

    Much of the field of stem cell biology and development remains uncharted territory. Just as famous explorers and astronomers mapped out landmasses and constellations, researchers are working fervently to chart…

  • Researchers identify promising cancer drug target in prostate tumors

    Scientists at Dana-Farber Cancer Institute report they have blocked the development of prostate tumors in cancer-prone mice by knocking out a molecular unit they describe as a “powerhouse” that drives…

  • New source of heart stem cells discovered

    Harvard Stem Cell Institute(HSCI) researchers at Children’s Hospital Boston are continuing to document the heart’s earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that…

  • Previously unknown regulator of fat and cholesterol production discovered in mice

    Researchers have discovered an unknown regulator of fat and cholesterol production in the liver of mice, a significant finding that could eventually lead to new therapies for lowering unhealthy blood…

  • Boning up on frogs’ defenses

    Harvard biologists have determined that some African frogs carry concealed weapons: when threatened, these species puncture their own skin with sharp bones in their toes, using the bones as claws…

  • Scientists isolate a toxic key to Alzheimer’s disease in human brains

    Scientists have long questioned whether the abundant amounts of amyloid plaques found in the brains of patients with Alzheimer’s actually caused the neurological disease or were a by-product of its…

  • Research in brief

    BLACKS, HISPANICS LESS LIKELY TO GET FOLLOW-UP RADIATION THERAPY, BLACKS MORE LIKELY TO CHOOSE AGGRESSIVE CARE AT END OF LIFE

  • Aquatic genome captures foreign DNA

    Long viewed as straitlaced spinsters, sexless freshwater invertebrate animals known as bdelloid rotifers may actually be far more promiscuous than anyone had imagined: Scientists at Harvard University have found that the genomes of these common creatures are chock-full of DNA from plants, fungi, bacteria, and animals.

  • Protective mechanism fails when obesity sets in

    Reporting in the journal Cell Metabolism, researchers from the Harvard School of Public Health (HSPH) said they have shown for the first time that fat-storing cells, or adipocytes, contain a protective anti-inflammatory immune mechanism that prevents the cells from overreacting to inflammation-causing stimuli, such as fatty acids in the diet.

  • Cluzel named professor of molecular and cellular biology, applied physics

    Philippe Cluzel has been appointed professor of molecular and cellular biology and Gordon McKay Professor of Applied Physics in Harvard University’s Faculty of Arts and Sciences (FAS) and School of Engineering and Applied Sciences, effective July 1.

  • New report finds low vitamin D levels appear common in ‘healthy’ children

    Many infants and toddlers may have low levels of vitamin D, and about one-third of those appear to have some evidence of reduced bone mineral content on X-rays, according to a report in the June issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

  • Video game technology may help surgeons

    In a study funded by the National Institutes of Health (NIH) featured on the cover of this month’s Journal of Thoracic and Cardiovascular Surgery, cardiac surgeons from Children’s Hospital Boston report good results with a simple technology borrowed from the gaming industry: stereo glasses.

  • Decline in cigarette smoking in U.S. significantly offset by increase in other tobacco products

    While trends in cigarette smoking and sales have declined in the U.S. for the past decade, sales of non-cigarette tobacco products have been on the rise. Researchers from the Harvard…

  • Video game technology may help surgeons operate on beating hearts

    Surgery has been done inside some adults’ hearts while the heart is still beating, avoiding the need to open the chest, stop the heart and put patients on cardiopulmonary bypass.…

  • HSPH student takes aim at AIDS with statistics

    Bethany Hedt has always been in love with numbers. Her challenge has been finding a way to feed that love while fulfilling an equally strong drive to help the people around her.

  • John Passanese eyes the alternatives

    Yoga is a popular activity for many Harvard undergraduates looking to stay fit or reduce stress. For John Passanese, a Lowell House senior, yoga has additional importance — it can be an excellent tool for managing chronic pain. For more than 20 years, Passanese’s mother has suffered from multiple sclerosis (MS), a neurodegenerative disease that attacks the body’s central nervous system. MS can cause a range of debilitating symptoms, including cognitive disabilities, paralysis, loss of vision, and chronic pain. There is no known cure.

  • NIH awards HMS $117.5M, five-year grant for patient-centered research

    The National Institutes of Health (NIH) has announced that Harvard Medical School (HMS) will receive $117.5 million over the next five years for the establishment of a Clinical and Translational Science Center (CTSC) that will transform patient-oriented, laboratory-to-bedside research at HMS and its affiliated hospitals.