{"id":329129,"date":"2021-07-08T05:00:45","date_gmt":"2021-07-08T09:00:45","guid":{"rendered":"https:\/\/news.harvard.edu\/gazette\/?p=329129"},"modified":"2023-11-08T20:02:39","modified_gmt":"2023-11-09T01:02:39","slug":"epa-omega-3-fatty-acid-reduces-cardiovascular-events","status":"publish","type":"post","link":"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/","title":{"rendered":"The omega-3 fatty acid that may improve heart health"},"content":{"rendered":"<header\n\tclass=\"wp-block-harvard-gazette-article-header alignfull article-header is-style-full-width-text-below centered-image\"\n\tstyle=\" \"\n>\n\t<figure class=\"wp-block-image\"><img fetchpriority=\"high\" decoding=\"async\" alt=\"A 3D illustration concept of the human heart\" height=\"1667\" loading=\"eager\" src=\"https:\/\/news.harvard.edu\/gazette\/wp-content\/uploads\/2021\/07\/Heart-iStock.jpg\" width=\"2500\"\/><figcaption class=\"wp-element-caption\"><p class=\"wp-element-caption--credit\">iStock<\/p><\/figcaption><\/figure>\n\n\t<div class=\"article-header__content\">\n\t\t\t<a\n\t\t\tclass=\"article-header__category\"\n\t\t\thref=\"https:\/\/news.harvard.edu\/gazette\/section\/health\/\"\n\t\t>\n\t\t\tHealth\t\t<\/a>\n\t\t\n\t\t<h1 class=\"article-header__title wp-block-heading \">\n\t\tThe omega-3 fatty acid that may improve heart health\t<\/h1>\n\n\t\n\t\t\t<\/div>\n\t\t\n\t<div class=\"article-header__meta\">\n\t\t<div class=\"wp-block-post-author\">\n\t\t\t<address class=\"wp-block-post-author__content\">\n\t\t\t\t\t<p class=\"author wp-block-post-author__name\">\n\t\tHaley Bridger\t<\/p>\n\t\t\t<p class=\"wp-block-post-author__byline\">\n\t\t\tBWH Communications\t\t<\/p>\n\t\t\t\t\t<\/address>\n\t\t<\/div>\n\n\t\t<time class=\"article-header__date\" datetime=\"2021-07-08\">\n\t\t\tJuly 8, 2021\t\t<\/time>\n\n\t\t<span class=\"article-header__reading-time\">\n\t\t\t2 min read\t\t<\/span>\n\t<\/div>\n\n\t\n\t\t\t<h2 class=\"article-header__subheading wp-block-heading\">\n\t\t\tEPA significantly reduces cardiovascular events\t\t<\/h2>\n\t\t\n<\/header>\n\n\n\n<div class=\"wp-block-group alignwide has-global-padding is-content-justification-center is-layout-constrained wp-block-group-is-layout-constrained\">\n\n\n\t\t<p>In 2018, a study found that a high dose of an omega-3 fatty acid given to patients with an elevated cardiac risk significantly reduced cardiovascular events.<\/p>\n<p>Findings from the Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine. This helped the prescription drug icosapent get approved by the U.S. Food and Drug Administration, Health Canada, and European Medicines Agency to reduce cardiovascular risk in patients with elevated triglycerides. However, subsequent studies of supplements that combine purified ethyl ester of eicosapentaenoic acid (EPA) \u00a0and docosahexaenoic acid (DHA) have had mixed results.<\/p>\n<p>Deepak L Bhatt,\u00a0executive director of\u00a0<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__www.brighamandwomens.org_heart-2Dand-2Dvascular-2Dcenter_programs_interventional-2Dcardiology-2Dprogram&amp;d=DwMFAg&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=1jCE580DbS6scAUM5vgokMbc7mxUG7dMi_Rar3eDD_I&amp;s=OEF4-V6cia__RCLbc6y5jCZvZpJ3i9qUzNitN53EFnc&amp;e=\">Interventional Cardiovascular Programs<\/a> at the Brigham and lead investigator of the REDUCE-IT trial, along with colleagues at Harvard-affiliated Brigham and Women\u2019s Hospital, performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. These showed higher relative reductions in cardiovascular outcomes using only EPA.<\/p>\n<p>\u201cREDUCE-IT has ushered in a new era in cardiovascular prevention,\u201d said <a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/416\/deepak-bhatt-cardiovascular_medicine-boston\">Bhatt<\/a>. \u201cREDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA.\u201d<\/p>\n<p>In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes.<\/p>\n<p>The researchers note that there are crucial biological differences between EPA and DHA. While both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.<\/p>\n<p>\u201cThis meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA,\u201d said Bhatt. \u201cIt should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings.\u201d<\/p>\n<p><em>REDUCE-IT was sponsored by Amarin. Brigham and Women\u2019s Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.\u00a0<\/em><\/p>\n\n\n<\/div>\n\n\t\t","protected":false},"excerpt":{"rendered":"<p>A high dose of a purified ethyl ester of eicosapentaenoic acid in patients at elevated cardiac risk significantly reduces cardiovascular events.<\/p>\n","protected":false},"author":131912214,"featured_media":329143,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"gz_ga_pageviews":192,"gz_ga_lastupdated":"2023-07-02 03:21","document_color_palette":"blue","author":"Haley Bridger","affiliation":"BWH Communications","_category_override":"","_yoast_wpseo_primary_category":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[39644],"tags":[48614,6556,48612,48611,48610,25500,48613,48609],"gazette-formats":[],"series":[],"class_list":["post-329129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-amarin","tag-brigham-and-womens-hospital","tag-deepak-l-bhatt","tag-docosahexaenoic-acid","tag-eicosapentaenoic-acid","tag-new-england-journal-of-medicine","tag-omega-3-fatty-acid","tag-reduce-it"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.0 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>EPA omega-3 fatty acid reduces cardiovascular events &#8212; Harvard Gazette<\/title>\n<meta name=\"description\" content=\"A high dose of a purified ethyl ester of eicosapentaenoic acid in patients at elevated cardiac risk significantly reduces cardiovascular events.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EPA omega-3 fatty acid reduces cardiovascular events\" \/>\n<meta property=\"og:description\" content=\"A high dose of a purified ethyl ester of eicosapentaenoic acid in patients at elevated cardiac risk significantly reduces cardiovascular events.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/\" \/>\n<meta property=\"og:site_name\" content=\"Harvard Gazette\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-08T09:00:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-09T01:02:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/news.harvard.edu\/gazette\/wp-content\/uploads\/2021\/07\/Heart-iStock.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2500\" \/>\n\t<meta property=\"og:image:height\" content=\"1667\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sam Seifman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"EPA omega-3 fatty acid reduces cardiovascular events\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/\"},\"author\":{\"name\":\"Sam Seifman\",\"@id\":\"https:\/\/news.harvard.edu\/gazette\/#\/schema\/person\/e66ec876712e2ddb949133e41b88e718\"},\"headline\":\"The omega-3 fatty acid that may improve heart health\",\"datePublished\":\"2021-07-08T09:00:45+00:00\",\"dateModified\":\"2023-11-09T01:02:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/\"},\"wordCount\":375,\"publisher\":{\"@id\":\"https:\/\/news.harvard.edu\/gazette\/#organization\"},\"image\":{\"@id\":\"https:\/\/news.harvard.edu\/gazette\/story\/2021\/07\/epa-omega-3-fatty-acid-reduces-cardiovascular-events\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/news.harvard.edu\/wp-content\/uploads\/2021\/07\/Heart-iStock.jpg\",\"keywords\":[\"Amarin\",\"Brigham and Women's Hospital\",\"Deepak L. 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width=\"2500\"\/><figcaption class=\"wp-element-caption\"><p class=\"wp-element-caption--credit\">iStock<\/p><\/figcaption><\/figure>\n"],"rendered":"<header\n\tclass=\"wp-block-harvard-gazette-article-header alignfull article-header is-style-full-width-text-below centered-image\"\n\tstyle=\" \"\n>\n\t<figure class=\"wp-block-image\"><img alt=\"A 3D illustration concept of the human heart\" height=\"1667\" loading=\"eager\" src=\"https:\/\/news.harvard.edu\/gazette\/wp-content\/uploads\/2021\/07\/Heart-iStock.jpg\" width=\"2500\"\/><figcaption class=\"wp-element-caption\"><p class=\"wp-element-caption--credit\">iStock<\/p><\/figcaption><\/figure>\n\n\t<div class=\"article-header__content\">\n\t\t\t<a\n\t\t\tclass=\"article-header__category\"\n\t\t\thref=\"https:\/\/news.harvard.edu\/gazette\/section\/health\/\"\n\t\t>\n\t\t\tHealth\t\t<\/a>\n\t\t\n\t\t<h1 class=\"article-header__title wp-block-heading \">\n\t\tThe omega-3 fatty acid that may improve heart health\t<\/h1>\n\n\t\n\t\t\t<\/div>\n\t\t\n\t<div class=\"article-header__meta\">\n\t\t<div class=\"wp-block-post-author\">\n\t\t\t<address class=\"wp-block-post-author__content\">\n\t\t\t\t\t<p class=\"author wp-block-post-author__name\">\n\t\tHaley Bridger\t<\/p>\n\t\t\t<p class=\"wp-block-post-author__byline\">\n\t\t\tBWH Communications\t\t<\/p>\n\t\t\t\t\t<\/address>\n\t\t<\/div>\n\n\t\t<time class=\"article-header__date\" datetime=\"2021-07-08\">\n\t\t\tJuly 8, 2021\t\t<\/time>\n\n\t\t<span class=\"article-header__reading-time\">\n\t\t\t2 min read\t\t<\/span>\n\t<\/div>\n\n\t\n\t\t\t<h2 class=\"article-header__subheading wp-block-heading\">\n\t\t\tEPA significantly reduces cardiovascular events\t\t<\/h2>\n\t\t\n<\/header>\n"},"2":{"blockName":"core\/group","attrs":{"templateLock":false,"metadata":{"name":"Article content"},"align":"wide","layout":{"type":"constrained","justifyContent":"center"},"tagName":"div","lock":[],"className":"","style":[],"backgroundColor":"","textColor":"","gradient":"","fontSize":"","fontFamily":"","borderColor":"","ariaLabel":"","anchor":""},"innerBlocks":[{"blockName":"core\/freeform","attrs":{"content":"","lock":[],"metadata":[]},"innerBlocks":[],"innerHTML":"\n\t\t<p>In 2018, a study found that a high dose of an omega-3 fatty acid given to patients with an elevated cardiac risk significantly reduced cardiovascular events.<\/p>\n<p>Findings from the Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine. This helped the prescription drug icosapent get approved by the U.S. Food and Drug Administration, Health Canada, and European Medicines Agency to reduce cardiovascular risk in patients with elevated triglycerides. However, subsequent studies of supplements that combine purified ethyl ester of eicosapentaenoic acid (EPA) \u00a0and docosahexaenoic acid (DHA) have had mixed results.<\/p>\n<p>Deepak L Bhatt,\u00a0executive director of\u00a0<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__www.brighamandwomens.org_heart-2Dand-2Dvascular-2Dcenter_programs_interventional-2Dcardiology-2Dprogram&amp;d=DwMFAg&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=1jCE580DbS6scAUM5vgokMbc7mxUG7dMi_Rar3eDD_I&amp;s=OEF4-V6cia__RCLbc6y5jCZvZpJ3i9qUzNitN53EFnc&amp;e=\">Interventional Cardiovascular Programs<\/a> at the Brigham and lead investigator of the REDUCE-IT trial, along with colleagues at Harvard-affiliated Brigham and Women\u2019s Hospital, performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. These showed higher relative reductions in cardiovascular outcomes using only EPA.<\/p>\n<p>\u201cREDUCE-IT has ushered in a new era in cardiovascular prevention,\u201d said <a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/416\/deepak-bhatt-cardiovascular_medicine-boston\">Bhatt<\/a>. \u201cREDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA.\u201d<\/p>\n<p>In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes.<\/p>\n<p>The researchers note that there are crucial biological differences between EPA and DHA. While both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.<\/p>\n<p>\u201cThis meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA,\u201d said Bhatt. \u201cIt should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings.\u201d<\/p>\n<p><em>REDUCE-IT was sponsored by Amarin. Brigham and Women\u2019s Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.\u00a0<\/em><\/p>\n","innerContent":["\n\t\t<p>In 2018, a study found that a high dose of an omega-3 fatty acid given to patients with an elevated cardiac risk significantly reduced cardiovascular events.<\/p>\n<p>Findings from the Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine. This helped the prescription drug icosapent get approved by the U.S. Food and Drug Administration, Health Canada, and European Medicines Agency to reduce cardiovascular risk in patients with elevated triglycerides. However, subsequent studies of supplements that combine purified ethyl ester of eicosapentaenoic acid (EPA) \u00a0and docosahexaenoic acid (DHA) have had mixed results.<\/p>\n<p>Deepak L Bhatt,\u00a0executive director of\u00a0<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__www.brighamandwomens.org_heart-2Dand-2Dvascular-2Dcenter_programs_interventional-2Dcardiology-2Dprogram&amp;d=DwMFAg&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=1jCE580DbS6scAUM5vgokMbc7mxUG7dMi_Rar3eDD_I&amp;s=OEF4-V6cia__RCLbc6y5jCZvZpJ3i9qUzNitN53EFnc&amp;e=\">Interventional Cardiovascular Programs<\/a> at the Brigham and lead investigator of the REDUCE-IT trial, along with colleagues at Harvard-affiliated Brigham and Women\u2019s Hospital, performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. These showed higher relative reductions in cardiovascular outcomes using only EPA.<\/p>\n<p>\u201cREDUCE-IT has ushered in a new era in cardiovascular prevention,\u201d said <a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/416\/deepak-bhatt-cardiovascular_medicine-boston\">Bhatt<\/a>. \u201cREDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA.\u201d<\/p>\n<p>In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes.<\/p>\n<p>The researchers note that there are crucial biological differences between EPA and DHA. While both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.<\/p>\n<p>\u201cThis meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA,\u201d said Bhatt. \u201cIt should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings.\u201d<\/p>\n<p><em>REDUCE-IT was sponsored by Amarin. Brigham and Women\u2019s Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.\u00a0<\/em><\/p>\n"],"rendered":"\n\t\t<p>In 2018, a study found that a high dose of an omega-3 fatty acid given to patients with an elevated cardiac risk significantly reduced cardiovascular events.<\/p>\n<p>Findings from the Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine. This helped the prescription drug icosapent get approved by the U.S. Food and Drug Administration, Health Canada, and European Medicines Agency to reduce cardiovascular risk in patients with elevated triglycerides. However, subsequent studies of supplements that combine purified ethyl ester of eicosapentaenoic acid (EPA) \u00a0and docosahexaenoic acid (DHA) have had mixed results.<\/p>\n<p>Deepak L Bhatt,\u00a0executive director of\u00a0<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__www.brighamandwomens.org_heart-2Dand-2Dvascular-2Dcenter_programs_interventional-2Dcardiology-2Dprogram&amp;d=DwMFAg&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=1jCE580DbS6scAUM5vgokMbc7mxUG7dMi_Rar3eDD_I&amp;s=OEF4-V6cia__RCLbc6y5jCZvZpJ3i9qUzNitN53EFnc&amp;e=\">Interventional Cardiovascular Programs<\/a> at the Brigham and lead investigator of the REDUCE-IT trial, along with colleagues at Harvard-affiliated Brigham and Women\u2019s Hospital, performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. These showed higher relative reductions in cardiovascular outcomes using only EPA.<\/p>\n<p>\u201cREDUCE-IT has ushered in a new era in cardiovascular prevention,\u201d said <a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/416\/deepak-bhatt-cardiovascular_medicine-boston\">Bhatt<\/a>. \u201cREDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA.\u201d<\/p>\n<p>In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes.<\/p>\n<p>The researchers note that there are crucial biological differences between EPA and DHA. While both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.<\/p>\n<p>\u201cThis meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA,\u201d said Bhatt. \u201cIt should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings.\u201d<\/p>\n<p><em>REDUCE-IT was sponsored by Amarin. Brigham and Women\u2019s Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.\u00a0<\/em><\/p>\n"}],"innerHTML":"\n<div class=\"wp-block-group alignwide\">\n\n\n\n<\/div>\n","innerContent":["\n<div class=\"wp-block-group alignwide\">\n\n","\n\n<\/div>\n"],"rendered":"\n<div class=\"wp-block-group alignwide has-global-padding is-content-justification-center is-layout-constrained wp-block-group-is-layout-constrained\">\n\n\n\t\t<p>In 2018, a study found that a high dose of an omega-3 fatty acid given to patients with an elevated cardiac risk significantly reduced cardiovascular events.<\/p>\n<p>Findings from the Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial (REDUCE-IT) were published in the New England Journal of Medicine. This helped the prescription drug icosapent get approved by the U.S. Food and Drug Administration, Health Canada, and European Medicines Agency to reduce cardiovascular risk in patients with elevated triglycerides. However, subsequent studies of supplements that combine purified ethyl ester of eicosapentaenoic acid (EPA) \u00a0and docosahexaenoic acid (DHA) have had mixed results.<\/p>\n<p>Deepak L Bhatt,\u00a0executive director of\u00a0<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__www.brighamandwomens.org_heart-2Dand-2Dvascular-2Dcenter_programs_interventional-2Dcardiology-2Dprogram&amp;d=DwMFAg&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=1jCE580DbS6scAUM5vgokMbc7mxUG7dMi_Rar3eDD_I&amp;s=OEF4-V6cia__RCLbc6y5jCZvZpJ3i9qUzNitN53EFnc&amp;e=\">Interventional Cardiovascular Programs<\/a> at the Brigham and lead investigator of the REDUCE-IT trial, along with colleagues at Harvard-affiliated Brigham and Women\u2019s Hospital, performed a meta-analysis of 38 randomized clinical trials of omega-3 fatty acids, including trials of EPA monotherapy and EPA+DHA therapy. These showed higher relative reductions in cardiovascular outcomes using only EPA.<\/p>\n<p>\u201cREDUCE-IT has ushered in a new era in cardiovascular prevention,\u201d said <a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/416\/deepak-bhatt-cardiovascular_medicine-boston\">Bhatt<\/a>. \u201cREDUCE-IT was the largest and most rigorous contemporary trial of EPA, but there have been other ones as well. Now, we can see that the totality of evidence supports a robust and consistent benefit of EPA.\u201d<\/p>\n<p>In total, these trials included more than 149,000 participants. They evaluated key cardiovascular outcomes, including cardiovascular mortality, non-fatal cardiovascular outcomes, bleeding, and atrial fibrillation. Overall, omega-3 fatty acids reduced cardiovascular mortality and improved cardiovascular outcomes.<\/p>\n<p>The researchers note that there are crucial biological differences between EPA and DHA. While both are considered omega-3 fatty acids, they have different chemical properties that influence their stability and the effect that they can have on cholesterol molecules and cell membranes. No trials to date have studied the effects of DHA alone on cardiovascular outcomes.<\/p>\n<p>\u201cThis meta-analysis provides reassurance about the role of omega-3 fatty acids, specifically prescription EPA,\u201d said Bhatt. \u201cIt should encourage investigators to explore further the cardiovascular effects of EPA across different clinical settings.\u201d<\/p>\n<p><em>REDUCE-IT was sponsored by Amarin. Brigham and Women\u2019s Hospital receives research funding from Amarin for the work Bhatt did as the trial chair and as the international principal investigator. The present analysis was unfunded.\u00a0<\/em><\/p>\n\n\n<\/div>\n"}},"jetpack-related-posts":[{"id":360976,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2023\/06\/omega-3-fatty-acids-linked-with-slower-progression-of-als\/","url_meta":{"origin":329129,"position":0},"title":"Another study links omega-3s and health","author":"harvardgazette","date":"June 21, 2023","format":false,"excerpt":"Alpha-linolenic acid \u2014 an omega-3 fatty acid found in many nuts, seeds, and oils \u2014 showed the strongest link to slowing the progression and premature death of people living with ALS.","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"Artist's conception of Omega-3 links.","src":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2023\/06\/Omega-3.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2023\/06\/Omega-3.jpg?resize=350%2C200 1x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2023\/06\/Omega-3.jpg?resize=525%2C300 1.5x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2023\/06\/Omega-3.jpg?resize=700%2C400 2x"},"classes":[]},{"id":134191,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2013\/04\/eating-fish-gives-older-adults-an-edge\/","url_meta":{"origin":329129,"position":1},"title":"Eating fish gives older adults an edge","author":"harvardgazette","date":"April 1, 2013","format":false,"excerpt":"Older adults who have high blood levels of omega-3 fatty acids \u2014 found almost exclusively in fatty seafood \u2014 may be able to lower their overall mortality risk by as much as 27 percent and their mortality risk from heart disease by about 35 percent, according to a new study.","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"","src":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2013\/04\/fish_605.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2013\/04\/fish_605.jpg?resize=350%2C200 1x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2013\/04\/fish_605.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":248711,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2018\/08\/low-plasma-levels-of-omega-3-fatty-acids-associated-with-preterm-birth\/","url_meta":{"origin":329129,"position":2},"title":"Pregnant women encouraged to eat cold-water fish","author":"harvardgazette","date":"August 3, 2018","format":false,"excerpt":"Pregnant women with the lowest plasma levels of long-chain omega-3 fatty acids \u2014 the kind found in fish oil \u2014 were at 10 times increased risk of early preterm birth as pregnant women with the highest levels.","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"","src":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2018\/08\/cold-water-fish.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2018\/08\/cold-water-fish.jpg?resize=350%2C200 1x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2018\/08\/cold-water-fish.jpg?resize=525%2C300 1.5x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2018\/08\/cold-water-fish.jpg?resize=700%2C400 2x"},"classes":[]},{"id":59835,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2004\/02\/cystic-fibrosis-gene-linked-to-fatty-acid-defects\/","url_meta":{"origin":329129,"position":3},"title":"Cystic fibrosis gene linked to fatty acid defects","author":"harvardgazette","date":"February 4, 2004","format":false,"excerpt":"Researchers already understood that the defective CFTR gene causes CF, explains senior author Steven D. Freedman, M.D., Ph.D., of the gastroenterology division at BIDMC and associate professor of medicine at Harvard Medical School. \"But we didn't understand how this defective gene leads to the symptoms of the disease. This new\u2026","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":69689,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2010\/12\/dairy-diabetes\/","url_meta":{"origin":329129,"position":4},"title":"Dairy fat may help not harm","author":"harvardgazette","date":"December 20, 2010","format":false,"excerpt":"Scientists at the Harvard School of Public Health and collaborators from other institutions have identified a natural substance in dairy fat that may substantially reduce the risk of type 2 diabetes.","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"","src":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2010\/12\/cheese605.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2010\/12\/cheese605.jpg?resize=350%2C200 1x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2010\/12\/cheese605.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":337502,"url":"https:\/\/news.harvard.edu\/gazette\/story\/2022\/01\/vitamin-d-reduced-rate-of-autoimmune-diseases-by-22\/","url_meta":{"origin":329129,"position":5},"title":"Vitamin D supplements lower risk of autoimmune disease, researchers say","author":"harvardgazette","date":"January 26, 2022","format":false,"excerpt":"A new study finds vitamin D supplements with or without omega-3s decreased the risk of autoimmune diseases by 22 percent compared to placebo.","rel":"","context":"In &quot;Health&quot;","block_context":{"text":"Health","link":"https:\/\/news.harvard.edu\/gazette\/section\/health\/"},"img":{"alt_text":"Vitamin D.","src":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2022\/01\/michele-blackwell-2500-unsplash.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/news.harvard.edu\/wp-content\/uploads\/2022\/01\/michele-blackwell-2500-unsplash.jpg?resize=350%2C200 1x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2022\/01\/michele-blackwell-2500-unsplash.jpg?resize=525%2C300 1.5x, https:\/\/news.harvard.edu\/wp-content\/uploads\/2022\/01\/michele-blackwell-2500-unsplash.jpg?resize=700%2C400 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/posts\/329129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/users\/131912214"}],"replies":[{"embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/comments?post=329129"}],"version-history":[{"count":15,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/posts\/329129\/revisions"}],"predecessor-version":[{"id":329168,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/posts\/329129\/revisions\/329168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/media\/329143"}],"wp:attachment":[{"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/media?parent=329129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/categories?post=329129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/tags?post=329129"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/gazette-formats?post=329129"},{"taxonomy":"series","embeddable":true,"href":"https:\/\/news.harvard.edu\/gazette\/wp-json\/wp\/v2\/series?post=329129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}