Tag: Joslin Diabetes Center
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Nation & World
Study provides first physiological evidence that insulin is critical for blood vessel formation
For people with type 2 diabetes, the death rate from a first heart attack is two to three times the death rate of patients without the disease. Similarly, patients with…
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Nation & World
Internet discussion group provides an inspiring, supportive ‘oasis’ for people with diabetes, Joslin study shows
A study that appears in the November/December 2005 issue of The Diabetes Educator examined the impact of Joslin’s Online Discussion Boards – forums in which people with diabetes can find…
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Nation & World
High blood glucose levels in early pregnancy may deprive embryo of oxygen
Research appearing in the October 2005 issue of the American Journal of Physiology: Endocrinology and Metabolism suggests that high blood glucose levels early in pregnancy deprive the embryo of oxygen,…
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Nation & World
Study shows new compound may reduce risk of vision loss in patients with diabetes
The PKC-Diabetic Retinopathy Study (DRS) was designed to evaluate the safety and effect of an oral treatment, RBX, on retinopathy progression or visual loss in patients with moderately severe to…
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Nation & World
‘Brown fat’ cells hold clues for possible obesity treatments
In laboratory studies of mouse cells, the research team identified genes that govern how precursor cells give rise to mature brown fat cells. There are two main types of fat…
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Nation & World
Insulin prods development of type 1 diabetes
Joslin Diabetes Center researchers Diane Mathis’s and Christophe Benoist’s finding that the lymph node draining the pancreas was intrinsic to the autoimmune response in mice made David Hafler, HMS professor…
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Nation & World
Joslin Diabetes Center scientists find genetic defects in immunological tolerance
The genetic defect keeps the body from properly dealing with “errant” immune cells that it normally eliminates by a process called immunological tolerance. These immune cells then attack the insulin-producing…
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Nation & World
Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
To understand the increased risk factor, the researchers mated ordinary mice and separated the mothers into a control group that ate as much chow as they wanted throughout their pregnancies…
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Nation & World
Scientists discover “master switch” that triggers insulin resistance and type 2 diabetes
“We zeroed in on a factor called NF-kB,” said principal investigator Steven E. Shoelson, M.D., Ph.D., Helen and Morton Adler Chair and head of the Section on Cellular and Molecular…
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Nation & World
Dramatic gains shown with moderate weight loss, exercise
A study of 35 obese people included three groups of volunteers; all were obese and had a body mass index above 30 kg/m2 and had insulin resistance. The first group…
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Nation & World
Researchers shed light on genetic defects that cause diabetes
New findings by researchers at Joslin Diabetes Center visualize the protein that is mutated in most individuals having a form of diabetes called Maturity Onset Diabetes of the Young (MODY).…
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Nation & World
Researchers uncover remaining critical insulin gene regulatory factor
Scientists have known the identity of two genes that can influence the ability of insulin genes to trigger insulin production in the beta cells of the pancreas. Through subsequent research…
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Nation & World
Death protein may cause neural tube defects in babies of diabetic mothers
A research report provides a possible explanation for a class of birth defects that appears to be on the rise. A protein normally involved in programmed cell death may, as…
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Nation & World
Can weight loss decrease heart disease in type 2 diabetes?
Can weight loss decrease heart disease in type 2 diabetes? That’s the question being asked by Harvard researchers and others based at three Boston medical centers. In a nationwide study…
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Nation & World
Common aspirin reveals mechanism of insulin resistance
In 1876, a German professor described a treatment that led to rapid improvement in two men who were suffering from what doctors now recognize as classic type 2 diabetes. In…
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Nation & World
Brain found to play unexpected role in Type II diabetes
Until now, the brain was assumed to be a side player in diabetes. “For the most part, diabetes researchers have not been looking at the brain,” said C. Ronald Kahn,…
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Nation & World
Shadow proteins in thymus may explain how immune system gets to know its own body
Researchers recently identified a protein that appears to work by turning on in the thymus, which lies beneath the breast bone, the production of a wide array of proteins from…