Health

Depression and anxiety linked to increased risk of heart attack or stroke

Mass General Brigham Communications

December 18, 2025

3 min read

Study suggests stress reduction holds potential for cardiovascular disease prevention

Patients with depression are at higher risk of cardiovascular disease, and a new study suggests that stress may help explain why.

Research from Harvard-affiliated Mass General Brigham indicates that the increased risk is driven by stress-related brain activity, nervous system dysregulation, and chronic inflammation. Investigators also found that patients with both depression and anxiety were at even higher risk of cardiovascular disease than those diagnosed with just one condition. The findings, published in Circulation: Cardiovascular Imaging, suggest that stress reduction and related therapeutic targets hold potential for cardiovascular disease prevention.

The researchers analyzed data from 85,551 participants in the Mass General Brigham Biobank. Of these, 14,934 presented with both depression and anxiety, 15,819 had either depression or anxiety, and 54,798 had neither condition. Participants were followed for a median of 3.4 years, during which 3,078 experienced major adverse cardiovascular events such as heart attack, heart failure, or stroke.

“In line with previous reports, we found that both depression and anxiety were linked to a higher risk of heart attack or stroke,” said senior author Ahmed Tawakol, director of Nuclear Cardiology at the Mass General Brigham Heart and Vascular Institute and associate professor of medicine at Harvard Medical School. “Notably people who were diagnosed with both depression and anxiety faced roughly a 32 percent higher risk compared with those diagnosed with only one condition. Importantly, these associations remained strong even after accounting for differences in lifestyle behaviors, socioeconomic factors, and traditional risk factors such as smoking, diabetes, and hypertension.”

“People who were diagnosed with both depression and anxiety faced roughly a 32 percent higher risk compared with those diagnosed with only one condition.”Ahmed Tawakol

To investigate whether depression and anxiety might be linked to heart health via systemic stress responses, the researchers also analyzed advanced brain imaging data and biomarkers of nervous system activity and inflammation for a subset of the participants. They found that people diagnosed with depression or anxiety showed increased activity in the amygdala (a brain region associated with stress), reduced heart rate variability (a sign of an overactive nervous system), and higher blood levels of CRP (a protein linked to inflammation).

“Together, these changes seem to form a biological chain linking emotional stress to cardiovascular risk,” said study first author Shady Abohashem, who is head of Cardiac PET/CT Imaging Trials, an investigator at the Cardiovascular Imaging Center of MGH, and an instructor in radiology at HMS. “When the brain’s stress circuits are overactive, they can chronically trigger the body’s ‘fight or flight’ system, leading to increased heart rate, blood pressure, and chronic inflammation. Over time, these changes can damage blood vessels and accelerate heart disease. This reinforces that protecting heart health isn’t just about diet or exercise, it’s also about emotional health.

“For clinicians, it’s a reminder to view mental health as an integral part of cardiovascular risk assessment. For patients, it’s encouragement that addressing chronic stress, anxiety, or depression is not just a mental health priority, it’s also a heart health priority,” added Abohashem.

Because the study was based on observational data, more research is needed to determine whether depression and anxiety are causing cardiovascular disease or whether they are simply associated. The researchers are now studying whether interventions such as stress-reduction therapies, anti-inflammatory medications, or lifestyle changes can help normalize these brain and immune markers and, in turn, lower heart risk.

The research described in this article was supported in part by the American Heart Association and National Institutes of Health.