Scientists at Harvard Stem Cell Institute have found a way to both make more energy-burning human brown fat cells and make the cells themselves more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases.
Four scientists from across Harvard will receive nearly $8 million in grant funding through the National Institutes of Health’s High Risk-High Reward program to support research into a variety of biomedical questions, ranging from how the bacterial cell wall is constructed to how the blood-brain barrier works.
Two groups of Harvard scientists will be among the first researchers nationwide to receive grant funding through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative launched last year by President Obama.
The Harvard Program in Therapeutic Science has received $30 million in grant funding over the five years from three U.S. government agencies to launch its new research activities, Harvard Medical School announced on Sept. 11.
Harvard researchers have released the first study to show that the adverse effects of fried foods may vary depending on the genetic makeup of the individual.
About 50% of adolescents born HIV-positive may be at increased risk for heart disease, including stroke and heart attack, later in life, according to ...
A new study led by Harvard Medical School Professor Dennis Selkoe provides specific, pre-clinical scientific evidence supporting the concept that prolonged and intensive stimulation by an enriched environment may have beneficial effects in delaying one of the key negative factors in Alzheimer’s disease.
Harvard stem cell biologists have proven that it is possible to turn one type of already differentiated neuron into another inside the brain, and their findings may have enormous implications for the treatment of neurodegenerative diseases.
Physicians may soon have a new way to screen patients for Barrett's esophagus, a precancerous condition usually caused by chronic exposure to stomach acid. Harvard researchers at the Wellman Center for Photomedicine at Massachusetts General Hospital have developed an imaging system enclosed in a capsule about the size of a multivitamin pill that creates detailed, microscopic images of the esophageal wall.
In a study from Harvard-affiliated Brigham and Women’s Hospital, researchers used a novel method to identify the new heart cells and describe their origins.
Patricia A. King, the Carmack Waterhouse Professor of Law, Medicine, Ethics, and Public Policy at Georgetown Law Center, plans to step down from the Harvard Corporation at the end of December, the University announced today.
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have created more than 100 3-D nanostructures using DNA building blocks that function like Lego bricks — a major advance from the two-dimensional structures the same team built a few months ago.
Scientist and Princeton University President Shirley Tilghman argued for a new approach to teaching science to college students, introducing it earlier in the learning process.
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have mimicked pulmonary edema in a microchip lined by living human cells. They used this “lung-on-a-chip” to study drug toxicity and identify potential new therapies to prevent this life-threatening condition.
Geneticist Elaine Ostrander runs a comparative-genomics lab that examines dog DNA to understand better the traits that might aid understanding of human diseases.
Harvard researchers at Dana-Farber Cancer Institute find that aspirin therapy can extend the life of colorectal cancer patients whose tumors carry a mutation in a key gene, but it has no effect on patients who lack the mutation.
Scientists have long known the main proteins that lead to the development of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), respectively. Now research shows that these two motor neuron diseases likely share a pathway that leads to the development of disease.
A new study describes the mechanism behind impaired muscle repair during aging and a strategy that may help rejuvenate aging tissue by manipulating the environment in which muscle stem cells reside.
According to a study by researchers at Harvard-affiliated Brigham and Women’s Hospital, women who took ibuprofen or acetaminophen two or more days per week had an increased risk of hearing loss.
For the first time, Harvard scientists have created a type of cyborg tissue by embedding a 3-D network of functional, biocompatible, nanoscale wires into engineered human tissues.
A team of researchers at Harvard University and the California Institute of Technology has turned inanimate silicon and living cardiac muscle cells into a freely swimming “jellyfish.”
A consortium of scientists at 20 institutions, led by a principal faculty member at the Harvard Stem Cell Institute, has used stem cells to take a major step toward developing personalized medicine to treat Parkinson’s disease.
A fond look back at the memorable events of Harvard's 375th year.
A “proof-of-concept” study that applies financial portfolio theory to federal life science research funding shows that potentially significant gains are available by altering the allocation of funding by the National Institutes of Health.
A new study by Harvard School of Public Health (HSPH) researchers has found that a subclass of high-density lipoprotein (HDL) cholesterol, the so-called good cholesterol, may not protect against coronary heart disease (CHD) and in fact may be harmful.
MGH’s Herbert Benson, author of “The Relaxation Response,” says that the methods outlined in his book can create genetic changes in irritable bowel syndrome sufferers, and with further study might be used to treat other ailments.
Two Harvard pediatric cancer researchers at Dana-Farber Cancer Institute (DFCI) and a scientist at Columbia University Medical Center have each received $100,000 Bridge Grants from a private foundation seeking to help make up for declining federal biomedical research funding.
Synaptic plasticity — the ability of the synaptic connections between the brain’s neurons to change and modify over time — has been shown to be a key to memory formation and the acquisition of new learning behaviors. Now research reveals that the neural circuits controlling hunger and eating behaviors are also controlled by plasticity.
A team led by researchers at Harvard-affiliated Dana-Farber Cancer Institute has isolated a natural hormone from muscle cells that triggers some of the key health benefits of exercise.
Harvard researchers have found a treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease and other neurodegenerative disorders.
Harvard researchers are among a nationwide team that has found serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns.
Physician and Harvard Medical School Professor Arthur Kleinman delivered Harvard Divinity School’s annual William James Lecture, exploring the philosopher’s importance in the area of moral wisdom.
In a scientific first that could shed light on how signals travel in the brain and how learning alters neural pathways, scientists at Harvard have created genetically altered neurons that light up as they fire. The work may also lead to speedier drug development.
A combination of two drugs may alleviate radiation sickness in people who have been exposed to high levels of radiation, even when the therapy is given a day after the exposure occurred, according to a study led by scientists from Harvard-affiliated Dana-Farber Cancer Institute (DFCI) and Children’s Hospital Boston.
Researchers at Harvard Medical School and Children’s Hospital Boston have retraced the evolution of an unusual bacterial infection as it spread among cystic fibrosis patients by sequencing scores of samples collected during the outbreak, since contained.
In a discovery that might eventually lead to new biomedical treatments for disease, researchers from Harvard’s Department of Molecular and Cellular Biology have identified two types of RNA that are able to move between cells as part of a process called RNA-interference (RNAi).
Researchers have built a map that shows how thousands of proteins in a fruit fly cell communicate with each other. This is the largest and most detailed protein interaction map of a multicellular organism, demonstrating how approximately one-third of the proteins cooperate to keep life going.
Two young Harvard scientists will each receive $2.54 million or more in National Institutes of Health grants that will support research and overhead costs through a new program intended to accelerate the entry of outstanding junior investigators into independent researcher positions.
In a new research paper published in the Proceedings of the National Academy of Sciences Early Edition online, Harvard-affiliated researchers identify a transcriptional biomarker that may assist in the monitoring of Huntington's disease activity and in the evaluation of new medications.
Nine researchers from across Harvard have received more than $15 million in special National Institutes of Health (NIH) grants designed to foster innovative research with the potential to propel fields forward and speed the translation of research into improved public health.
A Harvard study of how mice respond to scent cues from potential mates, competitors, and nearby predators has laid a foundation for further investigations that may eventually lead to a greater understanding of social recognition in the animal brain, with implications for a host of human disorders ranging from autism to post-traumatic stress disorder.
Scientists at Harvard-affiliated Dana-Farber Cancer Institute have successfully disrupted the function of a cancer gene involved in the formation of most human tumors by tampering with the gene’s “on” switch and growth signals, rather than targeting the gene itself.
Researchers from Harvard-affiliated Dana-Farber Cancer Institute and the Scripps Research Institute in Jupiter, Fla., report they have created prototype drugs having powerful anti-diabetic effects, yet apparently free — at least in mice — of dangerous side effects plaguing some current diabetes medications.
The global obesity epidemic has been escalating for decades, yet long-term prevention efforts have barely begun and are inadequate, according to a new paper from international public health experts published in the Aug. 25 issue of the journal The Lancet.
A novel imaging probe developed by a Harvard-led team of investigators at Massachusetts General Hospital may make it possible to diagnose accurately a dangerous infection of the heart valves.
Between conception and birth, the human gut grows more than two meters long, looping and coiling within the tiny abdomen. Within a given species, the developing vertebrate gut always loops into the same formation — however, until now, it has not been clear why.
Harvard research finds that sleep-disordered breathing is associated with a higher risk of cognitive impairment in older women.
After decades of failed efforts, researchers have discovered, through a combination of digital database mining and laboratory assays, the linchpin protein that drives mitochondria’s calcium machinery.
Harvard Medical School researchers find that ovarian cancer cells use mechanical force to move through tissue and colonize additional organs.
Researchers at Joslin Diabetes Center, a Harvard Medical School affiliate, examine why a select group of long-term type 1 diabetes survivors show so few complications.