A study of plaque production at single-cell level holds promise to help improve Alzheimer’s treatment.
Rett syndrome is a relatively common neurodevelopmental disorder, the second most common cause of intellectual disability in girls after Down syndrome. Building on 2004 findings, Harvard researchers identified a faulty signaling pathway that, when corrected in mice, improves the symptoms of Rett syndrome.
Researchers have found that cancer begins after activation of an oncogene or loss of a tumor suppressor, and involves a change that takes a single cell back to a stem cell state. They believe this model may apply not only to melanoma, but to most if not all cancers.
Researchers at MIT’s David H. Koch Institute for Integrative Cancer Research, in collaboration with scientists at the Harvard Stem Cell Institute and several other institutions, have developed an implantable device that in mice shielded insulin-producing beta cells from immune system attack for six months — a substantial proportion of life span.
Scientists identify a molecular key that helps cells maintain identity and prevents the conversion of adult cells into induced pluripotent stem cells — a process that would require a cell to “forget” its identity before assuming a new one.
Harvard Stem Cell Institute researchers have shown that the networks of communication among reprogrammed neurons and their neighbors in the brains of living animals can also be changed, or “rewired.”
Researchers create complex kidney structures from human stem cells derived from the skin of adult patients.
Harvard researchers report that by identifying and mimicking important developmental cues, they have been able to drive cells to grow into muscle fibers capable of contracting in a dish and multiplying in large numbers. This new method of producing muscle cells could offer a better model for studying muscle diseases, such as muscular dystrophy, and for testing potential treatments.
Harvard Stem Cell Institute researchers at Massachusetts Eye and Ear have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Using large-scale zebrafish drug-screening models, Harvard Stem Cell Institute researchers at Boston Children’s Hospital have identified a potent group of chemicals that helps bone marrow transplants engraft, or “take.”
Scientists at Harvard Stem Cell Institute have found a way to both make more energy-burning human brown fat cells and make the cells themselves more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases.
Harvard Stem Cell Institute researchers at Massachusetts General Hospital have developed an “imageable” mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study, published online in the journal Brain, also describes a strategy for preventing the potential negative consequences of stem cell therapy.
A protein that is necessary for the formation of the vertebrate brain has been identified by researchers at the Harvard Stem Cell Institute (HSCI) and Boston Children’s Hospital, in collaboration with scientists from Oxford and Rio de Janeiro.
Harvard Stem Cell Institute researchers at McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease.
Collaborating with scientists elsewhere, Harvard Stem Cell Institute researchers have devised two methods for using stem cells to generate the type of neurons that help regulate behavioral and basic physiological functions in the human body, such as obesity and hypertension, sleep, mood, and some social disorders.
Harvard Stem Cell Institute researchers have taken what they describe as “the first step toward a pill that can replace the treadmill” for the control of obesity.
Harvard researchers have uncovered an easily detectable, “premalignant” state in the blood that significantly increases the likelihood that an individual will go on to develop blood cancers such as leukemia, lymphoma, or myelodysplastic syndrome.
Harvard Stem Cell Institute researchers at Boston Children’s Hospital and Harvard’s Department of Stem Cell and Regenerative Biology have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory distress.
Harvard Stem Cell Institute scientists at Brigham and Women’s Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions.
Harvard Stem Cell Institute researchers have demonstrated that adult cells, reprogrammed into another cell type in a living animal, can remain functional over a long period. The work is an important advance in the effort to develop cell-based therapies for tissue repair, and specifically in the effort to develop improved treatment for diabetes.
Harvard Stem Cell Institute researchers at Massachusetts General and Boston Children’s hospitals for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
Harvard stem cell researchers announced a giant leap forward in the quest to find a truly effective treatment for type 1 diabetes, a disease that affects an estimated 3 million Americans.
A Harvard Stem Cell Institute study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant of shifts in their energy supply than their normal counterparts. The results suggest there could be ways to target and kill cancer cells without affecting healthy cells.
Studies begun by Harvard Stem Cell Institute scientists eight years ago have led to a report that may be a major step in developing treatments for amyotrophic lateral sclerosis, or Lou Gehrig’s disease.
Harvard-affiliated researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule that acts as a marker for hard-to-find limbal stem cells.
A team at Harvard Stem Cell Institute recently found that transplanting mesenchymal stem cells along with blood-vessel-forming cells naturally found in circulation improves results. This co-transplantation keeps the mesenchymal stem cells alive longer in mice after engraftment, up to a few weeks compared with hours without co-transplantation.
Harvard Stem Cell Institute scientists collaborating with researchers at the University of Pennsylvania have developed a “genome-editing” approach for permanently reducing cholesterol levels in mice through a single injection, a development with the potential to reduce the risk of heart attacks in humans by 40 to 90 percent.
Divinity School graduate Shelley Brown is combining her love for science and religion to help stitch together two fields that rarely seem to meet.
The Harvard Stem Cell Institute is now 10 years old. What began as an idea embracing cross-disciplinary research quickly became a generator of scientific discoveries.
Harvard scientists have merged stem cell and “organ-on-a-chip” technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine, because it is working proof that a chunk of tissue containing a patient’s specific genetic disorder can be replicated in the laboratory.
Researchers at the Harvard Stem Cell Institute have shown that a protein, one they previously demonstrated can make failing hearts in aging mice appear more like those of young and healthy mice, similarly improves brain and skeletal muscle function in aging mice.
Harvard Stem Cell Institute researchers at Boston Children’s Hospital have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells have the functional hallmarks of HSCs and are able to self-renew like those cells.
Myelin, the electrical insulating material in the body long known to be essential for the fast transmission of impulses along the axons of nerve cells, is not as ubiquitous as thought, according to new work led by Professor Paola Arlotta.
Harvard stem cell scientists have discovered that a recently approved medication for epilepsy might be a meaningful treatment for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder.
A Harvard research team led by Kevin Kit Parker, a Harvard Stem Cell Institute principal faculty member, has identified a set of 64 crucial parameters by which to judge stem cell-derived cardiac myocytes, making it possible for scientists and pharmaceutical companies to quantitatively judge and compare the value of stem cells.
Harvard stem cell scientists have successfully converted skins cells from patients with early onset Alzheimer’s into the types of neurons affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells.
Harvard stem cell scientists studying the effect of nitric oxide on liver growth and regeneration appear to have serendipitously discovered a markedly improved treatment for liver damage caused by acetaminophen toxicity.
Research by Harvard Stem Cell Institute scientists shows that much lincRNA, which had been generally believed useless, plays an important role in the genome.
Harvard stem cell scientists have discovered that the same chemicals that stimulate muscle development in zebrafish can be used to differentiate human stem cells into muscle cells in the laboratory, which makes muscle cell therapy a more realistic clinical possibility.
They began with a discovery in zebrafish in 2007, and now researchers at the Harvard Stem Cell Institute (HSCI) have published initial results of a Phase Ib human clinical trial of a therapeutic that could improve the success of blood stem cell transplantation. This marks the first time that HSCI has carried a discovery from the lab bench to the clinic.
An international scientific collaborative led by the Harvard Stem Cell Institute’s Kornelia Polyak has discovered why women who give birth in their early 20s are less likely to develop breast cancer than women who don’t, triggering a search for a way to confer this protective state on all women.
Amy Wagers and Emmanuelle Passegué have found that cancer stem cells actively remodel the environment of bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants.
Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.
With plans to develop a career in medical research, Jennifer Cloutier is graduating from Harvard with her interest reinforced on research and medicine.
After college, Joshua Wortzel plans to build upon his Harvard research that focused on tissue regeneration. He hopes to work in translational medicine, helping to create drugs that might augment patients’ lives.
In the nine years since its founding, The Harvard Stem Cell Institute has become the world leader in stem cell biology.
Two Harvard Stem Cell Institute researchers have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the form of age-related heart failure that affects millions of Americans, a study says.
Researchers at the Harvard Stem Cell Institute have discovered a hormone that holds promise for a dramatically more effective treatment of type 2 diabetes, a metabolic illness afflicting an estimated 26 million Americans.
Using a new, stem cell-based, drug-screening technology that could reinvent and greatly reduce the cost of developing pharmaceuticals, researchers at the Harvard Stem Cell Institute have found a compound that is more effective in protecting the neurons killed in amyotrophic lateral sclerosis than are two drugs that failed in human clinical trials.
Harvard stem cell biologists have proven that it is possible to turn one type of already differentiated neuron into another inside the brain, and their findings may have enormous implications for the treatment of neurodegenerative diseases.