A team of scientists has engineered a form of the genome-editing protein Cas9 that can be controlled by a small molecule and offers improved DNA specificity.
Researchers have assembled the first high-resolution, 3-D maps of entire folded genomes and found a structural basis for gene regulation, a kind of “genomic origami” that allows the same genome to produce different types of cells.
Led by David Liu, professor of chemistry and chemical biology, a team of Harvard researchers developed a system that uses commercially available molecules called cationic lipids to deliver genome-editing proteins into cells.
New research illuminates the mixing with Neanderthals in early human prehistory, narrowing the window of time when they crossbred to between 50,000 and 60,000 years ago.
Harvard researchers working at the Broad Institute of MIT and Harvard have uncovered nine rare genetic mutations that dramatically increase the risk of developing type 2 diabetes. The discovery of the mutations highlights the dizzying genetic diversity of a disease rapidly spreading around the world.
Experts in child health gathered at Harvard Medical School on Tuesday for a symposium on how genome biology is changing children’s health.
Harvard researchers recently developed the most detailed “specificity profile” for Cas9 — a “machine” made of protein and RNA that can be programmed to target specific DNA sequences and to precisely cut, paste, and turn on or turn off genes. Future researchers will use the data when developing genetic tools and therapies.
An international team of researchers has decoded the genome of a creature whose evolutionary history is both enigmatic and illuminating: the African coelacanth
Scientists at Harvard have pioneered a breakthrough technique that can reproduce an individual’s entire genome from a single cell. The development could revolutionize everything from cancer treatment, by allowing doctors to obtain a genetic fingerprint of a person’s cancer early in treatment, to prenatal testing.
Geneticist Elaine Ostrander runs a comparative-genomics lab that examines dog DNA to understand better the traits that might aid understanding of human diseases.
Researchers have found that a parasitic flower takes large portions of its genetic code from its host, and that some genes borrowed by the flowers may even be functional. The surprising finding suggests that the process may convey some evolutionary advantage to the flowers.
Eight faculty led programs designed to give students international experience have received grants from the President’s Innovation Fund for International Experiences.
A landmark effort to sequence the genome of the butterfly Heliconius melpomene has revealed that it shares genes that control color patterns with two species that closely mimic its appearance — Heliconius timareta and Heliconius elevatus — suggesting that all three exchange genes as a result of occasional hybridization.
University of Chicago evolutionary biologist Jerry Coyne says that dysfunction within American society promotes high levels of religious belief that in turn blocks general acceptance of evolutionary theories.
A new imaging technique, developed by Erez Lieberman-Aiden, a Junior Fellow of the Society of Fellows, is giving scientists their first three-dimensional view of the human genome, one that is already shedding new light on a number of what Liberman-Aiden calls the “central mysteries of biology.”
Researchers at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute are collaborating on a massive, long-term effort to collect and analyze tumor tissue from 10,000 cancer patients annually. The researchers hope the data will enable them to understand better how tumors behave, while providing opportunities to test new therapies.
The green anole lizard is an agile and active creature, and so are elements of its genome. This genomic agility and other new clues have emerged from the full sequencing of the lizard’s genome and may offer insights into how the genomes of humans, mammals, and their reptilian counterparts have evolved since mammals and reptiles parted ways 320 million years ago.
Treating the chromosome as both an editable and an evolvable template, researchers have demonstrated methods to rewrite a cell’s genome through powerful new tools for biotechnology, energy, and agriculture.
Harvard scientists have unveiled the most comprehensive picture to date of the full genetic blueprint of multiple myeloma, a form of blood cancer.
Graduate student Alice A. Chen received the prestigious $30,000 Lemelson-MIT Student Prize on Wednesday (March 9) for her innovative applications of microtechnology to study human health and disease.
Harvard President Drew Faust hosted a panel discussion on the legacy of the Human Genome Project Feb. 22 at Sanders Theatre.
To mark the 10th anniversary of the publication of the Human Genome Map, Harvard President Drew Faust will host a panel discussion on the project next week (Feb. 22) in Sanders Theatre.
For the first time, researchers have laid bare the full genetic blueprint of multiple prostate tumors, uncovering alterations that have never before been detected and offering a deep view of the genetic missteps that underlie the disease.
Unlike previous investigations, which examined fat cells at a single static time point, this new study mapped several histone modifications throughout the course of fat cell development. With these new findings researchers now have a better understanding of normal fat cell development, and going forward, they can compare normal fat cells with fat cells in disease states.