Tag: Genetics
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Nation & World
Harvard Medical School, MGH researcher Gary Ruvkun to share 2008 Lasker Award
Gary Ruvkun, a Harvard Medical School genetics professor in the Massachusetts General Hospital (MGH) Center for Computational and Integrative Biology, is one of three scientists named co-recipients of the 2008…
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Nation & World
NHGRI/NIH awards Harvard researchers $6.5M
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), awarded a $6.5 million grant (over four years) to a team of Harvard University researchers to further develop electronic sequencing in nanopores. The grant is part of more than $20 million in total funding given by NHGRI/NIH to spur innovative…
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Nation & World
HMS to host quantitative genomics conference, more
The second annual Conference in Quantitative Genomics will be held Sept. 23-25 at the Harvard School of Public Health (HSPH). Hosted by the Program in Quantitative Genomics at the School, “Emerging Quantitative Issues in Parallel Sequencing” is supported with a grant from the National Cancer Institute and the National Heart, Lung and Blood Institute.
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Nation & World
Eli and Edythe Broad make unprecedented gift
Los Angeles-based philanthropists Eli and Edythe Broad on Sept. 4 declared the Broad Institute of Harvard and MIT an unprecedented success as an experiment in science and philanthropy and announced that they have increased their total gift to the Broad by $400 million to $600 million. The $400 million will be an endowment to convert…
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Nation & World
Broad awarded $86M NIH grant to develop chemical probes for disease
Researchers at the Broad Institute of Harvard and MIT have been chosen to receive a six-year, $86 million grant from the National Institutes of Health (NIH) to identify and develop molecular tools known as “small molecules,” which can probe proteins, signaling pathways, and cellular processes that are crucial to human health and disease.
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Nation & World
HSCI researchers see major breakthrough
In a feat of biological prestidigitation likely to turn the field of regenerative medicine on its head, Harvard Stem Cell Institute (HSCI) co-director Doug Melton and postdoctoral fellow Qiao “Joe” Zhou report having achieved what has long been a dream and ultimate goal of developmental biologists — directly turning a fully formed adult cell into…
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Nation & World
When genetics gets personal
Just five years after the Human Genome Project announced it had decoded the first human DNA, the era of personal genetics is dawning, bringing with it not just the promise of targeted, personalized medicine and a new level of self-knowledge, but also a host of ethical, legal, and practical issues. A new project out of…
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Nation & World
Eli and Edythe L. Broad endow the Broad Institute of Harvard and MIT with additional $400 million
Los Angeles-based philanthropists Eli and Edythe Broad today declared the Broad Institute of Harvard and MIT an unprecedented success as an experiment in science and philanthropy, and announced that they…
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Nation & World
Daley and colleagues create 20 disease-specific stem cell lines
Harvard Stem Cell Institute (HSCI) researcher George Q. Daley, associate director of the Stem Cell Program at Children’s Hospital Boston, has with HSCI colleagues Chad Cowan and Konrad Hochedlinger of Massachusetts General Hospital (MGH) produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem…
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Nation & World
A rare glimpse of schizophrenia’s genetic roots
The delusions and hallucinations of schizophrenia can be devastating for the 1% of the population struck by the disease. The condition clearly has a genetic component, evidenced by its tendency…
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Nation & World
Across species, genes evolve to minimize protein production errors
Scientists at Harvard University and the University of Texas, Austin, have found that genetic evolution is strongly shaped by genes’ efforts to prevent or tolerate errors in protein production.
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Nation & World
Aquatic genome captures foreign DNA
Long viewed as straitlaced spinsters, sexless freshwater invertebrate animals known as bdelloid rotifers may actually be far more promiscuous than anyone had imagined: Scientists at Harvard University have found that the genomes of these common creatures are chock-full of DNA from plants, fungi, bacteria, and animals.
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Nation & World
Molecular analysis confirms T. Rex’s evolutionary link to birds
Putting more meat on the theory that dinosaurs’ closest living relatives are modern-day birds, molecular analysis of a shred of 68-million-year-old Tyrannosaurus rex protein — along with that of 21…
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Nation & World
Genetics key in new knowledge about complex diseases
Genetic researchers crossed a critical threshold last year in their ability to understand complex diseases, posting a number of new discoveries that advanced knowledge of ailments caused by small contributions from multiple genes, the environment, and other causes.
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Nation & World
A Genetic Cause for Iron Deficiency
The discovery of a gene for a rare form of inherited iron deficiency may provide clues to iron deficiency in the general population – particularly iron deficiency that doesn’t respond…
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Nation & World
Study shows indicator for cardiovascular events
A study appearing in this week’s (March 19) New England Journal of Medicine (NEJM) confirms that a combination of gene variants previously associated with cholesterol levels does reflect patients’ cholesterol levels and can signify increased risk of heart attack, stroke, or sudden cardiac death. Led by researchers from the Massachusetts General Hospital (MGH) cardiology division,…
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Nation & World
Of flies and fish
During her schooldays in 1950s Germany, Christiane Nüsslein-Volhard rarely did her homework. In 1995, she won the Nobel Prize for physiology and medicine. Volhard is now director of the prestigious Max Planck Institute for Developmental Biology in Tübingen, where, decades before, she had been an undistinguished biochemistry undergraduate. She was at Harvard this week (March…
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Nation & World
Newly identified gene variants associated with prostate cancer risk
Three studies presenting newly identified genetic variants that are associated with increased susceptibility to prostate cancer were published recently (Feb. 10) on the advance online site of Nature Genetics. The 10 gene variants double the number of known variants associated with risk of the disease and are the result of genomewide association studies.
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Nation & World
Research in brief
Major differences in protocols used to determine brain death; Harvard researchers achieve stem cell milestone; Consortium links chromosome abnormality to autism disorders; Blocking HIV infection; Oral osteoporosis meds appear to reduce the risk of jaw degradation; Six new genetic variants linked to heart-disease risk factor; Gene variation may elevate risk of liver tumor in some…
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Nation & World
‘Where do I come from?’
Harvard graduates often return to the University to let their professors know what they’ve been up to since they finished their degree.
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Nation & World
Chromosomal abnormality linked to autism disorders
Researchers have fitted another piece into the complex genetic puzzle that is autism, finding DNA deletions and duplications on a specific chromosome that they say explains one to two percent…
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Nation & World
Gene variation may elevate risk of liver tumor in patients with cirrhosis
A genetic variation appears to significantly increase the risk that individuals with cirrhosis of the liver will develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause…
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Nation & World
Scientists identify gene responsible for statin-induced muscle pain
Statins, the popular class of drugs used to lower cholesterol, are among the most commonly prescribed medications in developed countries. But for some patients, accompanying side effects of muscle weakness and pain become chronic problems and, in rare cases, can escalate to debilitating and even life-threatening damage.
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Nation & World
Genome study charts genetic landscape of lung cancer
An international team of scientists Sunday (Nov. 4) announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world’s leading cause of cancer deaths.
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Nation & World
Researchers track down arthritis gene
Researchers at Brigham and Women’s Hospital and the Broad Institute of MIT and Harvard have discovered a gene involved in rheumatoid arthritis, a painful inflammation that affects 2.1 million Americans and which can destroy cartilage and bone within the afflicted joint.
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Nation & World
Decoding effort reveals fly species’ DNA
An enormous effort to decode the DNA of one of science’s most important laboratory animals — the fruit fly — ended in success this week as a collaboration of researchers from 16 nations announced the sequencing of 10 fly species’ genomes.
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Nation & World
Researchers track down rheumatoid arthritis gene
Researchers at Brigham and Women’s Hospital (BWH) and the Broad Institute of MIT and Harvard have discovered a gene involved in rheumatoid arthritis, a painful autoimmune disease that affects 2.1…
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Nation & World
Study paints genetic portrait of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world’s leading cause of cancer deaths. Appearing in…
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Nation & World
DNA reveals Neanderthal redheads
Ancient DNA retrieved from the bones of two Neanderthals suggests that at least some of them had red hair and pale skin, scientists report this week in the journal Science. The international team says that Neanderthals’ pigmentation may even have been as varied as that of modern humans, and that at least 1 percent of…