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149 stories tagged ‘Children’s Hospital Boston’
Researchers regenerate zebrafish heart muscle
A research team led by Mark T. Keating showed that zebrafish can regenerate heart muscle within two months after a severe injury. The team, from the Howard Hughes Medical Institute at Children’s Hospital Boston, also identified a possible genetic and molecular model for regeneration in zebrafish that could help direct further research in humans. The [...]
Protein predicts heart disease better than cholesterol
C-reactive protein’s claim to fame is based on its power to predict a woman’s risk of developing heart attack and stroke. In fact, high levels of C-reactive protein (CRP) were found to presage a woman’s chances of developing heart disease more accurately than that reigning oracle of the cardiology world, cholesterol. Researchers Paul Ridker, Nader [...]
Stem cells reduce brain damage
Mice with the kind of brain damage caused by strokes or cerebral palsy received implants of stem cells that resulted in the spontaneous replacement of many of the missing cells, according to Evan Snyder, a neurologist at the Harvard Medical School, who led the research. In other experiments, stem cells unexpectedly rescued the injured nerve [...]
Brake on Axon regrowth discovered
Since nerve cell axons in the mature central nervous system do not regrow, neurologists have no way of fully treating paralysis due to injury. “About a hundred years ago, people started asking why it was impossible to get the axon to regenerate upon injury,” said Zhigang He, Harvard Medical School assistant professor of neurology at [...]
Investigators discover method to stimulate brain rewiring after stroke
After a stroke, brain cells die and their connections to other parts of the brain are lost. In a study with rats conducted at Children’s Hospital in Boston, a naturally occurring substance called inosine was shown to stimulate nerve cells in undamaged parts of the brain to grow new connections into brain areas that had [...]
Six new breast cancer-susceptibility genes found
The discovery of six new cancer-susceptibility genes grew out of more than 10 years of research by Alan D’Andrea into Fanconi anemia, a condition known to affect only 500 families in the United States. Children born with the condition usually develop bone marrow failure early in life, leaving them unable to produce oxygen-carrying red blood [...]
One in five women iron deficient, many children also at risk
Iron-deficient anemia reduces the oxygen-carrying capacity of red blood cells, thus decreasing energy and endurance. When there is not enough iron, the red blood cells are not able to produce enough hemoglobin (the oxygen-transporting pigments found in red blood cells). Those affected may have pale skin and be excessively tired and ineffective at work or [...]
Researchers use therapeutic cloning to create functional tissue in cows
In a study, researchers obtained cow oocytes (donor eggs from cow ovaries) and removed and discarded the nuclei, which contain the cells’ genetic material, leaving behind just the shell. A skin cell from the cow’s ears was placed inside the egg shell and burst with electrical energy to expand the cell. That induced the one [...]
Black, Latino children with asthma receive lesser standard of care
Led by Tracy Lieu, associate professor of ambulatory care and prevention at Harvard Pilgrim Health Care and Harvard Medical School, the researchers interviewed parents of children with asthma who were insured by Medicaid programs. Of the children, 38 percent were black, 19 percent Latino, and 31 percent white. The researchers studied the effects of ethnicity [...]
Increased intake of dairy products may help reduce risk of insulin resistance
Milk intake has decreased significantly over the past three decades while the prevalence of obesity and type 2 diabetes has increased. The authors of a Harvard research study note that for most of the past 30 years, the U.S. Department of Agriculture and the American Heart Association have recommended low-fat diets for the prevention and [...]
Researchers find better way to predict childhood brain tumor outcomes
About 2,000 children a year are diagnosed with medulloblastoma, or brain tumor. In a study, researchers examined gene expression patterns from 99 patient tumor samples of three different types of brain tumors. In addition to distinguishing tumor types from each other, the study found strong expression of a signaling protein known as “Sonic Hedgehog,” which [...]
Sickle cell disease cured in mouse model
Sickle cell disease is a blood disorder caused by a single mutation in the beta-globin gene that results in the substitution of one amino acid. This small error is enough to change the properties of the protein: when “sickled,” the blood’s hemoglobin dumps its oxygen in tissues, and it tends to stick to itself. This [...]
New technique could repair severe birth defects
Physicians used to think that the amniotic fluid that cushions a fetus in the womb was junk, a kind of garbage bag into which the fetus urinates and sheds old cells. But recently two Harvard researchers took another look at amniotic cells and discovered that they could be used to grow new tissue. “We thought [...]
New study provides mixed report card on informed consent to cancer clinical trials
According to a study that appeared in the Nov. 24, 2001, issue of The Lancet, nearly one quarter of cancer patients who participate in clinical trials do not realize that the trials are conducted mainly to benefit future patients, not themselves. Many patients are unaware that experimental treatments are not yet proven to be better [...]
How media violence touches children
Children and adolescents are consuming more television than ever before. The average 8- to 18-year-old spends nearly seven hours each day involved with some form of media. Kids are also more violent than ever before. At the turn of the last century, children and adolescents were most likely to die of environmental causes, especially infectious [...]
How does the brain reinvent itself?
In order for us to use our minds for memory, for learning, and so forth, our brains must continually reinvent themselves. How do they do it? A Harvard Medical School research team has looked at the complicated interactions within nerve cells of ion channels, peptide hormones, growth factors, and a host of regulatory proteins and [...]
Researchers discover new type of cancer
A team led by a Harvard researcher has identified a new type of cancer that primarily affects young girls. Sara Vargas, an instructor in pathology at Harvard Medical School and a researcher in the Department of Pathology at Children’s Hospital in Boston, led the study that identified the new syndrome. The cancer is characterized by [...]
Harvard scientists identify chromosome location of genes associated with long life
Scientists have long thought of aging as a complex process affected by perhaps a thousand genes. So a recent discovery by Harvard scientists that a gene or genes located on a region of human Chromosome 4 may help people to live to age 100 was something of a surprise. “This is the first study to [...]
Amniotic cells may be source of new tissue
Babies born with congenital defects often require surgery. Surgeons face a problem, however — in adults, tissue for repair is borrowed from other areas of the body, but babies don’t have enough tissue to spare. Sometimes surgeons use teflon — certainly not an ideal replacement. The laboratory of Dario Fauza, Harvard Medical School instructor in [...]
Introducing baby to the right bacteria
Developing a symbiotic relationship with the right bacteria is essential for a baby’s health and development. W. Allan Walker, a researcher at Harvard Medical School and Massachusetts General Hospital, has been leading research into the complex relationship among the newborn gastrointestinal system, its bacterial immigrants, and the way breast milk helps regulate the process. Walker [...]
After years of setbacks, researcher Mark Keating has taken a giant step toward understanding the potential for regrowth of limbs and organs. He and his colleagues have managed to manipulate fully developed mouse muscle cells to the point where they revert to stem cells, uncommitted cells capable of growing into any type of cell. Further, [...]
How embryonic stem cells become fine-tuned brains
Research by Michael Greenberg, Harvard Medical School professor of neurology at Children’s Hospital, begins to explain how the embryonic brain’s stem cells decide whether to mature into nerve or glial cells as development proceeds. Greenberg and colleagues reported that neurogenin, a protein known to nudge stem cells toward turning into neurons, does so by actively [...]
Increased consumption of soda promotes childhood obesity
Soft drinks are currently the leading source of added sugars in the daily diet of young Americans. Now, researchers have conducted the first long-term study to examine soda consumption and its precise impact on children’s body weight. Their findings show that for each additional daily serving of a sugar-sweetened soft drink, the incidence of obesity [...]
Study says children with cancer often suffer needlessly
“Since caregivers are very committed to curing their patients, it may be difficult for them to recognize when to incorporate palliative care into treatments, even when there’s little hope of cure,” notes Joanne Wolfe, an instructor at Harvard Medical School and lead author of a report, published in The New England Journal of Medicine, that [...]
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