Researchers have found that cancer begins after activation of an oncogene or loss of a tumor suppressor, and involves a change that takes a single cell back to a stem cell state. They believe this model may apply not only to melanoma, but to most if not all cancers.
A team led by Harvard statistician Samuel Kou has devised a new system for tracking flu outbreaks in real time.
Harvard addiction specialist on FDA’s OxyContin OK: We have to respond to both patients and population health, a tricky task.
Catheter aided by UV light allows repairs of heart holes without requiring surgery.
The crisis in heroin addiction has mobilized law enforcement, public health officials, and scholars to push for substantial changes to drug policy.
A report on the science of getting hooked on heroin, one in a three-part series examining addiction and new ideas for combatting it.
Matthew Desmond, the John L. Loeb Associate Professor of the Social Sciences, and Beth Stevens, an assistant professor of neurology at Harvard Medical School and neuroscientist at Boston Children’s Hospital, have been named MacArthur Fellows.
Using large-scale zebrafish drug-screening models, Harvard Stem Cell Institute researchers at Boston Children’s Hospital have identified a potent group of chemicals that helps bone marrow transplants engraft, or “take.”
Researchers have found that measles vaccine coverage among the exposed populations is far below that necessary to keep the virus in check. The study is the first to positively link measles vaccination rates and the ongoing outbreak.
A protein that is necessary for the formation of the vertebrate brain has been identified by researchers at the Harvard Stem Cell Institute (HSCI) and Boston Children’s Hospital, in collaboration with scientists from Oxford and Rio de Janeiro.
Harvard-affiliated researchers have provided a see-through zebrafish and enhanced imaging that offer the first direct glimpse of how blood stem cells take root in the body to generate blood.
The Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine provides support for junior faculty amid life’s crunch time, when demanding research labs, children at home, and other duties all clamor for attention.
A study by Harvard researchers is the first to explore new parents’ attitudes toward genomic testing on newborns. The findings suggest that if such testing becomes available, there would be an interest among new parents, regardless of their demographic background.
Harvard Stem Cell Institute researchers at Boston Children’s Hospital and Harvard’s Department of Stem Cell and Regenerative Biology have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory distress.
Harvard Stem Cell Institute researchers at Massachusetts General and Boston Children’s hospitals for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
A new device inspired by the human spleen and developed by a team at Harvard’s Wyss Institute for Biologically Inspired Engineering may radically transform the way doctors treat sepsis.
Studies begun by Harvard Stem Cell Institute scientists eight years ago have led to a report that may be a major step in developing treatments for amyotrophic lateral sclerosis, or Lou Gehrig’s disease.
Harvard-affiliated researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule that acts as a marker for hard-to-find limbal stem cells.
A team at Harvard Stem Cell Institute recently found that transplanting mesenchymal stem cells along with blood-vessel-forming cells naturally found in circulation improves results. This co-transplantation keeps the mesenchymal stem cells alive longer in mice after engraftment, up to a few weeks compared with hours without co-transplantation.
The Harvard Stem Cell Institute is now 10 years old. What began as an idea embracing cross-disciplinary research quickly became a generator of scientific discoveries.
Fraternal twins Rosh and Roshan Sethi have shared much of their lives, including at Yale as undergraduates and sharing an apartment while enrolled at Harvard Medical School. Now preparing to graduate, they’re anticipating diverging careers, with Roshan exploring radiation oncology and Rosh head and neck surgery.
Harvard scientists have merged stem cell and “organ-on-a-chip” technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine, because it is working proof that a chunk of tissue containing a patient’s specific genetic disorder can be replicated in the laboratory.
Harvard Stem Cell Institute researchers at Boston Children’s Hospital have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells have the functional hallmarks of HSCs and are able to self-renew like those cells.
Founding donor Hansjörg Wyss doubled his gift to Harvard’s Wyss Institute for Biologically Inspired Engineering from $125 million to $250 million to the University to further advance the institute’s pioneering work.
he National Football League Players Association (NFLPA) has awarded Harvard Medical School a $100 million grant to create a transformative 10-year initiative — Harvard Integrated Program to Protect and Improve the Health of NFLPA Members.
According to researchers, results from a meta-analysis of 11 independent amyotrophic lateral sclerosis (ALS) research studies are giving hope to the ALS community by showing, for the first time, that the fatal disease may be treatable.
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have mimicked pulmonary edema in a microchip lined by living human cells. They used this “lung-on-a-chip” to study drug toxicity and identify potential new therapies to prevent this life-threatening condition.
In research, treatment, and outreach, researchers from Harvard Medical School are taking on the childhood obesity epidemic in the United States. This is the first in a three-part series.
A new study by Harvard researchers and published in the Journal of the American Medical Association (JAMA) challenges the notion that “a calorie is a calorie.”