New low-cost rotavirus vaccine could reduce disease burden in developing countries

A new vaccine for rotavirus was found to be 66.7 percent effective in preventing severe gastroenteritis caused by the virus, according to a new study from researchers at Harvard T.H. Chan School of Public Health and Epicentre, Paris. Rotavirus is responsible for about 37 percent of deaths from diarrhea among children younger than 5 years of age each year, or about 450,000 children, with a disproportionate effect in sub-Saharan Africa.

The study was published in the March 23, 2017 issue of the New England Journal of Medicine.

Rotavirus is the leading cause of acute diarrhea, or severe gastroenteritis, in children. Unlike other causes of diarrhea, improvements in water, sanitation, and hygiene do not prevent rotavirus transmission, therefore vaccination is essential to prevent death and complications from childhood diarrhea. 

To make a difference in countries where the rotavirus burden is highest and access to health care is low, vaccines need to be affordable, as well as safe, effective, and heat-stable. Currently there are two rotavirus vaccines, but they are expensive and refrigeration must be maintained throughout the supply chain. In resource-poor countries such as Niger, electricity and refrigeration are often unreliable. The new vaccine is heat-stable, the first of its kind for rotavirus prevention.  

“This trial brings a vaccine which is adapted to African settings to those who need it most,” said first author Sheila Isanaka, assistant professor of nutrition at Harvard Chan School. “When the vaccine becomes widely available in Africa, it will help protect millions of the most vulnerable children.”